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Commentary | Open Access

The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide

Luyao Wang1,2,, Rongyang Xu1,2,, Chengying Huang3,, Shanqiang Qu1,4 ( )
The Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
The First Clinical Medical College of Southern Medical University, Guangzhou, Guangdong, China
Department of Obstetrics and Gynecology, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

Luyao Wang, Rongyang Xu, and Chengying Huang contributed equally to this work and shared the first authorship.

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Keywords

ferroptosisglioblastomaTRIM7

References

1

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509(7498):105–109. https://doi.org/10.1038/nature13148
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Li K, Chen B, Xu A, Shen J, Li K, Hao K, et al. TRIM7 modulates NCOA4‐mediated ferritinophagy and ferroptosis in glioblastoma cells. Redox Biol. 2022;56:102451. https://doi.org/10.1016/j.redox.2022.102451
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Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, et al. Ferroptosis as a p53‐mediated activity during tumour suppression. Nature. 2015;520(7545):57–62. https://doi.org/10.1038/nature14344
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Yuan C, Liu J, Liu L, Jia H, Gao Q, Wang X, et al. TRIM7 suppresses cell invasion and migration through inhibiting HIF‐1α accumulation in clear cell renal cell carcinoma. Cell Biol Int. 2022;46(4):554–67. https://doi.org/10.1002/cbin.11750
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Cancer Innovation
Volume 2 Issue 4,
August 2023
Pages 237-239
DOI: 10.1002/cai2.77
Cite this article:
Wang L, Xu R, Huang C, et al. The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide. Cancer Innovation, 2023, 2(4): 237-239. https://doi.org/10.1002/cai2.77

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Published: 15 May 2023
© 2023 The Authors. Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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