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Over the past several decades, significant scientific progress in xenotransplantation has brought the field to the threshold of clinical trials. In the past 3 years in the United States, experimental pig kidney and heart xenotransplantation have been performed on human subjects recently declared dead by neurological criteria (decedents). In addition, two pig heart transplants have been carried out in living patients under the United States Food and Drug Administration's expanded access guidelines. However, though there has been a flurry of activity there remain unanswered questions regarding how the public views xenotransplantation, what concerns may exist, and how to address these concerns in a meaningful way. This paper aims to underscore the importance of public engagement in xenotransplantation, emphasizing the ongoing need for studies to assess public opinions. The current evidence on public engagement studies is reviewed and gaps in our understanding are identified. We propose practical steps to advance this field. Additional studies to determine the extent of racial/ethnic differences in attitudes to xenotransplantation should be conducted. Empirical and descriptive analysis of certain religious viewpoints—especially minority faiths—would be valuable. As public engagement is an important aspect of public acceptance of novel research that is accompanied by risk, we suggest that xenotransplantation biotechnology companies might consider leading the way in funding this research.
Locke JE, Kumar V, Anderson D, Porrett PM. Normal graft function after pig‐to‐human kidney xenotransplant. JAMA Surg. 2023;158(10):1106–8. https://doi.org/10.1001/jamasurg.2023.2774
Porrett PM, Orandi BJ, Kumar V, Houp J, Anderson D, Cozette Killian A, et al. First clinical‐grade porcine kidney xenotransplant using a human decedent model. Am J Transplant (AJT). 2022;22(4):1037–53. https://doi.org/10.1111/ajt.16930
Montgomery RA, Stern JM, Lonze BE, Tatapudi VS, Mangiola M, Wu M, et al. Results of two cases of pig‐to‐human kidney xenotransplantation. N Engl J Med. 2022;386(20):1889–98. https://doi.org/10.1056/NEJMoa2120238
Moazami N, Stern JM, Khalil K, Kim JI, Narula N, Mangiola M, et al. Pig‐to‐human heart xenotransplantation in two recently deceased human recipients. Nature Med. 2023;29(8):1989–97. https://doi.org/10.1038/s41591-023-02471-9
Hurst DJ, Padilla L, Rodger D, Schiff T, Cooper DKC. Close contacts of xenograft recipients: ethical considerations due to risk of xenozoonosis. Xenotransplantation. 2024;31(2):e12847. https://doi.org/10.1111/xen.12847
The Changsha Communiqué. First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials Changsha, China, 19–21 November 2008: The Changsha Communiqué. Xenotransplantation. 2009;16(2):61–3. https://doi.org/10.1111/j.1399-3089.2009.00520.x
Hawthorne WJ, Cowan PJ, Bühler LH, Yi S, Bottino R, Pierson RN, et al. Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018: “the 2018 Changsha communiqué” the 10‐year anniversary of the international consultation on xenotransplantation. Xenotransplantation. 2019;26(2):e12513. https://doi.org/10.1111/xen.12513
Cook PS. What constitutes adequate public consultation? Xenotransplantation proceeds in Australia. J Bioeth Inq. 2011;8(1):67–70. https://doi.org/10.1007/s11673-010-9269-8
Mitchell C, Lipps A, Padilla L, Werkheiser Z, Cooper DKC, Paris W. Meta‐analysis of public perception toward xenotransplantation. Xenotransplantation. 2020;27(4):e12583. https://doi.org/10.1111/xen.12583
DeLaura I, Anwar IJ, Ladowski J, Patino A, Cantrell S, Sanoff S. Attitudes of patients with renal disease on xenotransplantation: a systematic review. Xenotransplantation. 2023;30(2):e12794. https://doi.org/10.1111/xen.12794
Coffman KL, Sher L, Hoffman A, Rojter S, Folk P, Cramer DV, et al. Survey results of transplant patients' attitudes on xenografting. Psychosomatics. 1998;39(4):379–83. https://doi.org/10.1016/S0033-3182(98)71327-1
King K. Recipient and non‐recipient attitudes regarding xenotransplantation. EDTNA/ERCA J. 1998;24(3):25–6.
Conesa C, Ríos A, Ramírez P, Sánchez J, Sánchez E, Rodríguez MM, et al. Attitudes of primary care professionals in Spain toward xenotransplantation. Transplant Proc. 2006;38(3):853–7. https://doi.org/10.1016/j.transproceed.2006.02.025
Martínez‐Alarcón L, Ríos A, Ramis G, Quereda JJ, Herrero JM, Muñoz A, et al. Are veterinary students in favor of xenotransplantation? An opinion study in a Spanish university with a xenotransplantation program. Transplant Proc. 2010;42(6):2130–3. https://doi.org/10.1016/j.transproceed.2010.05.108
Mendonça L, Martínez‐Alarcón L, Ríos A, Ramis G, Quereda JJ, Abellaneda JM, et al. Are veterinary students in favour of xenotransplantation? Comparative opinion study in a Brazilian and a Spanish university. Transplant Proc. 2013;45(3):1046–9. https://doi.org/10.1016/j.transproceed.2013.02.004
Ríos A, Martínez‐Alarcón L, Ayala‐García MA, Sebastián MJ, Abdo‐Cuza A, López‐Navas A, et al. Level of acceptance of a clinical solid organ xenotransplantation program among personnel in organ transplant‐related services in Spanish, Mexican, and Cuban hospital centers. Transplant Proc. 2010;42(1):222–7. https://doi.org/10.1016/j.transproceed.2009.11.007
Ríos A, López‐Navas AI, De‐Francisco C, Sánchez Á, Hernández AM, Ramírez P, et al. Attitude toward organ and tissue xenotransplantation questionnaire (PCID‐XENOTx‐ríos): characteristics and psychometric properties of the validation in spanish‐speaking populations. Transplant Proc. 2018;50(8):2303–7. https://doi.org/10.1016/j.transproceed.2018.02.173
Hurst DJ, Padilla L. Ethically advancing pediatric cardiac xenotransplant. JAMA Pediatr. 2024;178(1):5–6. https://doi.org/10.1001/jamapediatrics.2023.4681
Padilla LA, Hurst D, Lopez R, Kumar V, Cooper DKC, Paris W. Attitudes to clinical pig kidney xenotransplantation among medical providers and patients. Kidney360. 2020;1(7):657–62. https://doi.org/10.34067/KID.0002082020
Padilla LA, Rhodes L, Sorabella RA, Hurst DJ, Cleveland DC, Dabal RJ, et al. Attitudes toward xenotransplantation: a survey of parents and pediatric cardiac providers. Pediatr Tranplant. 2021;25(2):e13851. https://doi.org/10.1111/petr.13851
Padilla LA, Sorabella RA, Carlo WF, Dabal RJ, Rhodes L, Cleveland DC, et al. Attitudes to cardiac xenotransplantation by pediatric heart surgeons and physicians. World J Pediatr Congenit Heart Surg. 2020;11(4):426–30. https://doi.org/10.1177/2150135120916744
Padilla LA, Hurst DJ, Jang K, Rosales JR, Sorabella RA, Cleveland DC, et al. Racial differences in attitudes to clinical pig organ xenotransplantation. Xenotransplantation. 2021;28(2):e12656. https://doi.org/10.1111/xen.12656
Hurst DJ, Padilla LA, Cooper DKC, Paris W. Factors influencing attitudes toward xenotransplantation clinical trials: a report of focus group studies. Xenotransplantation. 2021;28(4):e12684. https://doi.org/10.1111/xen.12684
Hurst DJ, Padilla LA, Cooper DK, Walters W, Paris W. The attitudes of religious group leaders towards xenotransplantation: a focus group study. Xenotransplantation. 2022;29(5):e12777. https://doi.org/10.1111/xen.12777
Paris W, Seidler RJH, FitzGerald K, Padela AI, Cozzi E, Cooper DKC. Jewish, Christian and Muslim theological perspectives about xenotransplantation. Xenotransplantation. 2018;25(3):e12400. https://doi.org/10.1111/xen.12400
Sautermeister J, Mathieu R, Bogner V. Xenotransplantation‐theological‐ethical considerations in an interdisciplinary symposium. Xenotransplantation. 2015;22(3):174–82. https://doi.org/10.1111/xen.12163
Bedzow I. Religious viewpoints: Judaism. Xenotransplantation. Cham: Springer International Publishing; 2023. p. 187–97. https://doi.org/10.1007/978-3-031-29071-8_16
Loike JD, Krupka M. The Jewish perspectives on xenotransplantation. Rambam Maimonides Med J. 2023;14(4):e0024. https://doi.org/10.5041/RMMJ.10511
Mohd Zailani MF, Hamdan MN, Mohd Yusof AN. Human‐pig chimeric organ in organ transplantation from Islamic bioethics perspectives. Asian Bioeth Rev. 2022;15(2):181–8. https://doi.org/10.1007/s41649-022-00233-2
Reese PP, Powe NR, Lo B. Engineering equity into the promise of xenotransplantation. Am J Kidney Dis. 2023;S0272–S6386 (23):00934–4. https://doi.org/10.1053/j.ajkd.2023.09.019
Boulware LE, Purnell TS, Mohottige D. Systemic kidney transplant inequities for black individuals: examining the contribution of racialized kidney function estimating equations. JAMA Netw Open. 2021;4(1):e2034630. https://doi.org/10.1001/jamanetworkopen.2020.34630
Brandon DT, Isaac LA, LaVeist TA. The legacy of Tuskegee and trust in medical care: is Tuskegee responsible for race differences in mistrust of medical care? J Nat Med Assoc. 2005;97(7):951–6.
Scharff DP, Mathews KJ, Jackson P, Hoffsuemmer J, Martin E, Edwards D. More than Tuskegee: understanding mistrust about research participation. J Health Care Poor Underserved. 2010;21(3):879–97. https://doi.org/10.1353/hpu.0.0323
Williams DR, Wyatt R. Racial bias in health care and health: challenges and opportunities. JAMA. 2015;314(6):555–6. https://doi.org/10.1001/jama.2015.9260
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