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Cardiac‐cerebral vascular diseases (CCVDs) are acknowledged as a major threat to public health, leading to more than one‐third of all deaths worldwide. The complex anatomical structure and immune features of blood vessels significantly affect the development of CCVDs, and magnetic resonance angiography (MRA) is one of the main diagnostic approaches for the accurate diagnosis and prognosis of CCVDs. However, MRA suffers from intrinsic problems derived from its blood flow‐dependency, and the clinical Gd‐chelating contrast agents are limited by their rapid vascular extravasation. Over the past decade, spurred on by nanoscience and nanotechnology, numerous contrast agents based on magnetic nanomaterials have been developed to enhance the contrast of MRA, with these including iron oxide nanoparticles, rare earth‐doped nanoparticles, and metal‐organic coordination polymers. The molecular MR imaging of vasculopathy using specific nanoprobes has been explored to obtain a better understanding of the molecular aspects of CCVDs. In this review, the state of the art in MRA nanoprobes is introduced, and recent achievements in the diagnosis of CCVDs using MR imaging are summarized. Additionally, the future prospects and limitations of MRA based on nanoprobes are discussed. The current review provides methodological designs and ideas for subsequent MRA nanoprobes.
Nabel EG. Cardiovascular disease. N Engl J Med. 2003;349(1):60–72. https://doi.org/10.1056/NEJMra035098
Wang YB, Zhang Y, Wang Z, Zhang J, Qiao RR, Xu M, et al. Optical/MRI dual‐modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO‐targeted upconversion luminescence probe. Biomaterials. 2019;219:119378. https://doi.org/10.1016/j.biomaterials.2019.119378
Fang Y, Yang RC, Hou Y, Wang YB, Yang N, Xu MQ, et al. Dual‐modality imaging of angiogenesis in unstable atherosclerotic plaques with VEGFR2‐targeted upconversion nanoprobes in vivo. Mol Imag Biol. 2022;24(5):721–31. https://doi.org/10.1007/s11307-022-01721-5
Liebeskind DS, Tomsick TA, Foster LD, Yeatts SD, Carrozzella J, Demchuk AM, et al. Collaterals at angiography and outcomes in the interventional management of stroke (IMS) Ⅲ trial. Stroke. 2014;45(3):759–64. https://doi.org/10.1161/STROKEAHA.113.004072
Maas MB, Lev MH, Ay H, Singhal AB, Greer DM, Smith WS, et al. Collateral vessels on CT angiography predict outcome in acute ischemic stroke. Stroke. 2009;40(9):3001–5. https://doi.org/10.1161/STROKEAHA.109.552513
Jolly SS, Yusuf S, Cairns J, Niemelä K, Xavier D, Widimsky P, et al. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011;377(9775):1409–20. https://doi.org/10.1016/S0140-6736(11)60404-2
Willinsky RA, Taylor SM, TerBrugge K, Farb RI, Tomlinson G, Montanera W. Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. Radiology. 2003;227(2):522–8. https://doi.org/10.1148/radiol.2272012071
Majoie CB, Sprengers ME, van Rooij WJ, Lavini C, Sluzewski M, van Rijn JC, et al. MR angiography at 3T versus digital subtraction angiography in the follow‐up of intracranial aneurysms treated with detachable coils. AJNR Am J Neuroradiol. 2005;26(6):1349–56.
Cohnen M, Wittsack HJ, Assadi S, Muskalla K, Ringelstein A, Poll LW, et al. Radiation exposure of patients in comprehensive computed tomography of the head in acute stroke. AJNR Am J Neuroradiol. 2006;27(8):1741–5.
Chen J, Einstein AJ, Fazel R, Krumholz HM, Wang Y, Ross JS, et al. Cumulative exposure to ionizing radiation from diagnostic and therapeutic cardiac imaging procedures: a population‐based analysis. J Am Coll Cardiol. 2010;56(9):702–11. https://doi.org/10.1016/j.jacc.2010.05.014
Rafailidis V, Huang DY, Yusuf GT, Sidhu PS. General principles and overview of vascular contrast‐enhanced ultrasonography. Ultrasonography. 2020;39(1):22–42. https://doi.org/10.14366/usg.19022
Golemati S, Cokkinos DD. Recent advances in vascular ultrasound imaging technology and their clinical implications. Ultrasonics. 2022;119:106599. https://doi.org/10.1016/j.ultras.2021.106599
Mintz GS, Guagliumi G. Intravascular imaging in coronary artery disease. Lancet. 2017;390(10096):793–809. https://doi.org/10.1016/S0140-6736(17)31957-8
Young CC, Bonow RH, Barros G, Mossa‐Basha M, Kim LJ, Levitt MR. Magnetic resonance vessel wall imaging in cerebrovascular diseases. Neurosurg Focus. 2019;47(6):E4. https://doi.org/10.3171/2019.9.FOCUS19599
Shang H, Zhao X, Zhang X. Vascular diseases. Singapore: Springer; 2022.
Azarine A, Scalbert F, Garçon P. Cardiac functional imaging. Presse Med. 2022;51(2):104119. https://doi.org/10.1016/j.lpm.2022.104119
Hyodo R, Takehara Y, Naganawa S. 4D Flow MRI in the portal venous system: imaging and analysis methods, and clinical applications. Radiol Med. 2022;127(11):1181–98. https://doi.org/10.1007/s11547-022-01553-x
Soufi G, Hekmatnia A, Iravani S, Varma RS. Nanoscale contrast agents for magnetic resonance imaging: a review. ACS Appl Nano Mater. 2022;5(8):10151–66. https://doi.org/10.1021/acsanm.2c03297
Cai WB, Chen XY. Nanoplatforms for targeted molecular imaging in living subjects. Small. 2007;3(11):1840–54. https://doi.org/10.1002/smll.200700351
Arbeille P, Eder V, Casset D, Quillet L, Hudelo C, Herault S. Real‐time 3‐D ultrasound acquisition and display for cardiac volume and ejection fraction evaluation. Ultrasound Med Biol. 2000;26(2):201–8. https://doi.org/10.1016/s0301-5629(99)00125-8
Gaeta M, Cavallaro M, Vinci SL, Mormina E, Blandino A, Marino MA, et al. Magnetism of materials: theory and practice in magnetic resonance imaging. Insights Imag. 2021;12(1):179. https://doi.org/10.1186/s13244-021-01125-z
Yi Z, Luo Z, Barth ND, Meng X, Liu H, Bu W, et al. In vivo tumor visualization through MRI off‐on switching of NaGdF4‐CaCO3 nanoconjugates. Adv Mater. 2019;31(37):e1901851. https://doi.org/10.1002/adma.201901851
Zhang PS, Cheng JW, Lu YJ, Zhang N, Wu X, Lin H, et al. Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac‐cerebral vascular diseases. Nat Commun. 2023;14(1):6149. https://doi.org/10.1038/s41467-023-41783-9
Saxena SK, Sharma M, Patel M, Oreopoulos D. Nephrogenic systemic fibrosis: an emerging entity. Int Urol Nephrol. 2008;40(3):715–24. https://doi.org/10.1007/s11255-008-9361-8
Yu MX, Zheng J. Clearance pathways and tumor targeting of imaging nanoparticles. ACS Nano. 2015;9(7):6655–74. https://doi.org/10.1021/acsnano.5b01320
Xu L, Ren ZY, Li GL, Xu D, Miao J, Ju J, et al. Liver‐targeting MRI contrast agent based on galactose functionalized o‐carboxymethyl chitosan. Front Bioeng Biotechnol. 2023;11:1134665. https://doi.org/10.3389/fbioe.2023.1134665
He F, Zhu L, Zhou X, Zhang P, Cheng J, Qiao Y, et al. Red blood cell membrane‐coated ultrasmall NaGdF(4) nanoprobes for high‐resolution 3D magnetic resonance angiography. ACS Appl Mater Interfaces. 2022;14(23):26372–81. https://doi.org/10.1021/acsami.2c03530
Zairov RR, Akhmadeev BS, Fedorenko SV, Mustafina AR. Recent progress in design and surface modification of manganese nanoparticles for MRI contrasting and therapy. Chem Eng J. 2023;459:141640. https://doi.org/10.1016/j.cej.2023.141640
Shokrollahi H. Contrast agents for MRI. Mater Sci Eng C. 2013;33(8):4485–97. https://doi.org/10.1016/j.msec.2013.07.012
Park SJ, Kim S, Lee S, Khim ZG, Char K, Hyeon T. Synthesis and magnetic studies of uniform iron nanorods and nanospheres. J Am Chem Soc. 2000;122(35):8581–2. https://doi.org/10.1021/ja001628c
Sun SH, Zeng H. Size‐controlled synthesis of magnetite nanoparticles. J Am Chem Soc. 2002;124(28):8204–5. https://doi.org/10.1021/ja026501x
Park J, An K, Hwang Y, Park JG, Noh HJ, Kim JY, et al. Ultra‐large‐scale syntheses of monodisperse nanocrystals. Nat Mater. 2004;3(12):891–5. https://doi.org/10.1038/nmat1251
Gao Z, Hou Y, Zeng J, Chen L, Liu C, Yang W, et al. Tumor microenvironment‐triggered aggregation of antiphagocytosis 99mTc‐labeled Fe3O4 nanoprobes for enhanced tumor imaging in vivo. Adv Mater. 2017;29(24):1701095. https://doi.org/10.1002/adma.201701095
Zhang PS, Li WY, Liu C, Zhu L, Cheng J, Pang R, et al. Simultaneous identifying the infarct core, collaterals, and penumbra after acute ischemic stroke with a low‐immunogenic MRI nanoprobe. Mater Des. 2023;233:112211. https://doi.org/10.1016/j.matdes.2023.112211
van den Brink H, Doubal FN, Duering M. Advanced MRI in cerebral small vessel disease. Int J Stroke. 2023;18(1):28–35. https://doi.org/10.1177/17474930221091879
Chen L, Hong WQ, Ren WY, Xu T, Qian Z, He Z. Recent progress in targeted delivery vectors based on biomimetic nanoparticles. Signal Transduct Targeted Ther. 2021;6(1):225. https://doi.org/10.1038/s41392-021-00631-2
Zhang PS, Meng JL, Li YY, Yang C, Hou Y, Tang W, et al. Nanotechnology‐enhanced immunotherapy for metastatic cancer. Innovation. 2021;2(4):100174. https://doi.org/10.1016/j.xinn.2021.100174
Gil PR, Hühn D, del Mercato LL, Sasse D, Parak WJ. Nanopharmacy: inorganic nanoscale devices as vectors and active compounds. Pharmacol Res. 2010;62(2):115–25. https://doi.org/10.1016/j.phrs.2010.01.009
Mills PH, Ahrens ET. Theoretical MRI contrast model for exogenous T2 agents. Magn Reson Med. 2007;57(2):442–7. https://doi.org/10.1002/mrm.21145
Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, et al. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc. 2005;127(35):12387–91. https://doi.org/10.1021/ja052337c
Bin Na H, Lee IS, Seo H, Park YI, Lee JH, Kim SW, et al. Versatile PEG‐derivatized phosphine oxide ligands for water‐dispersible metal oxide nanocrystals. Chem Commun. 2007(48):5167–9. https://doi.org/10.1039/b712721a
Li Z, Chen H, Bao HB, Gao M. One‐pot reaction to synthesize water‐soluble magnetite nanocrystals. Chem Mater. 2004;16(8):1391–3. https://doi.org/10.1021/cm035346y
Lu XY, Niu M, Qiao RR, Gao M. Superdispersible PVP‐coated Fe3O4 nanocrystals prepared by a “one‐pot” reaction. J Phys Chem B. 2008;112(46):14390–4. https://doi.org/10.1021/jp8025072
Li Z, Wei L, Gao M, Lei H. One‐pot reaction to synthesize biocompatible magnetite nanoparticles. Adv Mater. 2005;17(8):1001–5. https://doi.org/10.1002/adma.200401545
Zeng JF, Jing LH, Hou Y, Jiao M, Qiao R, Jia Q, et al. Anchoring group effects of surface ligands on magnetic properties of Fe3O4 nanoparticles: towards high performance MRI contrast agents. Adv Mater. 2014;26(17):2694–8. 2016. https://doi.org/10.1002/adma.201304744
Hu FQ, Li Z, Tu CF, Gao M. Preparation of magnetite nanocrystals with surface reactive moieties by one‐pot reaction. J Colloid Interface Sci. 2007;311(2):469–74. https://doi.org/10.1016/j.jcis.2007.03.023
Zhang PS, Zeng JF, Li YY, Yang C, Meng J, Hou Y, et al. Quantitative mapping of glutathione within intracranial tumors through interlocked MRI signals of a responsive nanoprobe. Angew Chem Int Ed Engl. 2021;60(15):8130–8. https://doi.org/10.1002/anie.202014348
Ma TC, Zhang PS, Hou Y, Ning H, Wang Z, Huang J, et al. “smart” nanoprobes for visualization of tumor microenvironments. Adv Healthcare Mater. 2018;7(20):e1800391. https://doi.org/10.1002/adhm.201800391
Quillard T, Croce K, Jaffer FA, Weissleder R, Libby P. Molecular imaging of macrophage protease activity in cardiovascular inflammation in vivo. Thromb Haemostasis. 2011;105(5):828–36. https://doi.org/10.1160/TH10-09-0589
Troncoso MF, Ortiz‐Quintero J, Garrido‐Moreno V, Sanhueza‐Olivares F, Guerrero‐Moncayo A, Chiong M, et al. VCAM‐1 as a predictor biomarker in cardiovascular disease. Biochim Biophys Acta, Mol Basis Dis. 2021;1867(9):166170. https://doi.org/10.1016/j.bbadis.2021.166170
Wishart DS, Bartok B, Oler E, Liang KYH, Budinski Z, Berjanskii M, et al. MarkerDB: an online database of molecular biomarkers. Nucleic Acids Res. 2021;49(D1):D1259–67. https://doi.org/10.1093/nar/gkaa1067
Broza YY, Zhou X, Yuan MM, Qu D, Zheng Y, Vishinkin R, et al. Disease detection with molecular biomarkers: from chemistry of body fluids to nature‐inspired chemical sensors. Chem Rev. 2019;119(22):11761–817. https://doi.org/10.1021/acs.chemrev.9b00437
Wang T, Hou Y, Bu B, Wang W, Ma T, Liu C, et al. Timely visualization of the collaterals formed during acute ischemic stroke with Fe(3) O(4) nanoparticle‐based MR imaging probe. Small. 2018;14(23):e1800573. https://doi.org/10.1002/smll.201800573
Wei C, Jiang ZY, Li CC, Li P, Fu Q. Nanomaterials responsive to endogenous biomarkers for cardiovascular disease theranostics. Adv Funct Mater. 2023;33(26):2214655. https://doi.org/10.1002/adfm.202214655
Hulshof AM, Hemker HC, Spronk HMH, Henskens YMC, ten Cate H. Thrombin‐fibrin(ogen) interactions, host defense and risk of thrombosis. Int J Mol Sci. 2021;22(5):2590. https://doi.org/10.3390/ijms22052590
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, et al. Inflammation in atherosclerosis. Circulation. 2006;114(1):55–62. https://doi.org/10.1161/circulationaha.106.619056
Johnson JL, Sala‐Newby GB, Ismail Y, Aguilera CM, Newby AC. Low tissue inhibitor of metalloproteinases 3 and high matrix metalloproteinase 14 levels defines a subpopulation of highly invasive foam‐cell macrophages. Arterioscler Thromb Vasc Biol. 2008;28(9):1647–53. https://doi.org/10.1161/ATVBAHA.108.170548
Bäck M, Ketelhuth DFJ, Agewall S. Matrix metalloproteinases in atherothrombosis. Prog Cardiovasc Dis. 2010;52(5):410–28. https://doi.org/10.1016/j.pcad.2009.12.002
Alabi A, Xia XD, Gu HM, Wang F, Deng SJ, Yang N, et al. Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. Nat Commun. 2021;12(1):1889. https://doi.org/10.1038/s41467-021-22167-3
Lenglet S, Thomas A, Chaurand P, Galan K, Mach F, Montecucco F. Molecular imaging of matrix metalloproteinases in atherosclerotic plaques. Thromb Haemostasis. 2012;107(3):409–16. https://doi.org/10.1160/th11-10-0717
Clemente C, Rius C, Alonso‐Herranz L, Martín‐Alonso M, Pollán Á, Camafeita E, et al. MT4‐MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Nat Commun. 2018;9(1):910. https://doi.org/10.1038/s41467-018-03351-4
Fan CX, Shi JJ, Zhuang Y, Zhang L, Huang L, Yang W, et al. Myocardial‐infarction‐responsive smart hydrogels targeting matrix metalloproteinase for on‐demand growth factor delivery. Adv Mater. 2019;31(40):e1902900. https://doi.org/10.1002/adma.201902900
Lutgens SPM, Cleutjens KBJM, Daemen MJAP, Heeneman S. Cathepsin cysteine proteases in cardiovascular disease. FASEB J. 2007;21(12):3029–41. https://doi.org/10.1096/fj.06-7924com
Weiss‐Sadan T, Ben‐Nun Y, Maimoun D, Merquiol E, Abd‐Elrahman I, Gotsman I, et al. A theranostic cathepsin activity‐based probe for noninvasive intervention in cardiovascular diseases. Theranostics. 2019;9(20):5731–8. https://doi.org/10.7150/thno.34402
Liu CL, Guo JL, Zhang X, Sukhova GK, Libby P, Shi GP. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nat Rev Cardiol. 2018;15(6):351–70. https://doi.org/10.1038/s41569-018-0002-3
Tu YF, Ma XW, Chen H, Fan Y, Jiang L, Zhang R, et al. Molecular imaging of matrix metalloproteinase‐2 in atherosclerosis using a smart multifunctional PET/MRI nanoparticle. Int J Nanomedicine. 2022;17:6773–89. https://doi.org/10.2147/IJN.S385679
Viswanathan S, Kovacs Z, Green KN, Ratnakar SJ, Sherry AD. Alternatives to gadolinium‐based metal chelates for magnetic resonance imaging. Chem Rev. 2010;110(5):2960–3018. https://doi.org/10.1021/cr900284a
Ni DL, Bu WB, Ehlerding EB, Cai W, Shi J. Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents. Chem Soc Rev. 2017;46(23):7438–68. https://doi.org/10.1039/c7cs00316a
Xing HY, Zhang SJ, Bu WB, Zheng X, Wang L, Xiao Q, et al. Ultrasmall NaGdF4 nanodots for efficient MR angiography and atherosclerotic plaque imaging. Adv Mater. 2014;26(23):3867–72. https://doi.org/10.1002/adma.201305222
Zeng YJ, Li HN, Li ZQ, Luo Q, Zhu H, Gu Z, et al. Engineered gadolinium‐based nanomaterials as cancer imaging agents. Appl Mater Today. 2020;20:100686. https://doi.org/10.1016/j.apmt.2020.100686
Antwi‐Baah R, Wang YJ, Chen XQ, Yu K. Metal‐based nanoparticle magnetic resonance imaging contrast agents: classifications, issues, and countermeasures toward their clinical translation. Adv Mater Interfac. 2022;9(9):2101710. https://doi.org/10.1002/admi.202101710
Zhang L, Liu RQ, Peng H, Li P, Xu Z, Whittaker AK. The evolution of gadolinium based contrast agents: from single‐modality to multi‐modality. Nanoscale. 2016;8(20):10491–510. https://doi.org/10.1039/c6nr00267f
Bridot JL, Faure AC, Laurent S, Rivière C, Billotey C, Hiba B, et al. Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging. J Am Chem Soc. 2007;129(16):5076–84. https://doi.org/10.1021/ja068356j
Li ZQ, Zhang Y, Jiang S. Multicolor core/shell‐structured upconversion fluorescent nanoparticles. Adv Mater. 2008;20(24):4765–9. https://doi.org/10.1002/adma.200801056
Hou Y, Qiao R, Fang F, Wang X, Dong C, Liu K, et al. NaGdF4 nanoparticle‐based molecular probes for magnetic resonance imaging of intraperitoneal tumor xenografts in vivo. ACS Nano. 2013;7(1):330–8. https://doi.org/10.1021/nn304837c
Johnson NJJ, Oakden W, Stanisz GJ, Scott Prosser R, van Veggel FCJM. Size‐tunable, ultrasmall NaGdF4 nanoparticles: insights into their T1 MRI contrast enhancement. Chem Mater. 2011;23(16):3714–22. https://doi.org/10.1021/cm201297x
Jiang ZL, Xia B, Ren F, Bao B, Xing W, He T, et al. Boosting vascular imaging‐performance and systemic biosafety of ultra‐small NaGdF(4) nanoparticles via surface engineering with rationally designed novel hydrophilic block co‐polymer. Small Methods. 2022;6(3):e2101145. https://doi.org/10.1002/smtd.202101145
Cao DJ. Macrophages in cardiovascular homeostasis and disease. Circulation. 2018;138(22):2452–5. https://doi.org/10.1161/CIRCULATIONAHA.118.035736
Hossaini Nasr S, Tonson A, El‐Dakdouki MH, Zhu DC, Agnew D, Wiseman R, et al. Effects of nanoprobe morphology on cellular binding and inflammatory responses: hyaluronan‐conjugated magnetic nanoworms for magnetic resonance imaging of atherosclerotic plaques. ACS Appl Mater Interfaces. 2018;10(14):11495–11507. https://doi.org/10.1021/acsami.7b19708
Wang Q, Wang Y, Liu SW, Sha X, Song X, Dai Y, et al. Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE (‐/‐) mice. J Nanobiotechnol. 2021;19(1):222. https://doi.org/10.1186/s12951-021-00962-w
Qiao HY, Wang YB, Zhang RH, Gao Q, Liang X, Gao L, et al. MRI/optical dual‐modality imaging of vulnerable atherosclerotic plaque with an osteopontin‐targeted probe based on Fe(3)O(4) nanoparticles. Biomaterials. 2017;112:336–45. https://doi.org/10.1016/j.biomaterials.2016.10.011
Qiao RR, Qiao HY, Zhang Y, Wang Y, Chi C, Tian J, et al. Molecular imaging of vulnerable atherosclerotic plaques in vivo with osteopontin‐specific upconversion nanoprobes. ACS Nano. 2017;11(2):1816–25. https://doi.org/10.1021/acsnano.6b07842
Thorarinsdottir AE, Harris TD. Metal‐organic framework magnets. Chem Rev. 2020;120(16):8716–89. https://doi.org/10.1021/acs.chemrev.9b00666
Wu D, Zhou JJ, Creyer MN, Yim W, Chen Z, Messersmith PB, et al. Phenolic‐enabled nanotechnology: versatile particle engineering for biomedicine. Chem Soc Rev. 2021;50(7):4432–83. https://doi.org/10.1039/d0cs00908c
Zhang PS, Hou Y, Zeng JF, Li Y, Wang Z, Zhu R, et al. Coordinatively unsaturated Fe(3+) based activatable probes for enhanced MRI and therapy of tumors. Angew Chem Int Ed Engl. 2019;58(32):11088–96. https://doi.org/10.1002/anie.201904880
Shin TH, Kim PK, Kang S, Cheong J, Kim S, Lim Y, et al. High‐resolution T(1) MRI via renally clearable dextran nanoparticles with an iron oxide shell. Nat Biomed Eng. 2021;5(3):252–63. https://doi.org/10.1038/s41551-021-00687-z
Grobner T, Prischl FC. Gadolinium and nephrogenic systemic fibrosis. Kidney Int. 2007;72(3):260–4. https://doi.org/10.1038/sj.ki.5002338
Aime S, Botta M, Geninatti Crich S, Giovenzana G, Palmisano G, Sisti M. Novel paramagnetic macromolecular complexes derived from the linkage of a macrocyclic Gd(Ⅲ) complex to polyamino acids through a squaric acid moiety. Bioconjugate Chem. 1999;10(2):192–9. https://doi.org/10.1021/bc980030f
Janicki R, Mondry A. Structural and thermodynamic aspects of hydration of Gd(ⅲ) systems. Dalton Trans. 2019;48(10):3380–91. https://doi.org/10.1039/c8dt04869j
Desser TS, Rubin DL, Muller HH, Qing F, Khodor S, Zanazzi G, et al. Dynamics of tumor imaging with Gd‐DTPA‐polyethylene glycol polymers: dependence on molecular weight. J Magn Reson Imag. 1994;4(3):467–72. https://doi.org/10.1002/jmri.1880040337
Huang Y, Boamah PO, Gong JB, Zhang Q, Hua M, Ye Y. Gd (Ⅲ) complex conjugate of low‐molecular‐weight chitosan as a contrast agent for magnetic resonance/fluorescence dual‐modal imaging. Carbohydr Polym. 2016;143:288–95. https://doi.org/10.1016/j.carbpol.2016.02.032
Lu YD, Liang ZY, Feng J, Huang L, Guo S, Yi P, et al. Facile synthesis of weakly ferromagnetic organogadolinium macrochelates‐based T(1)‐weighted magnetic resonance imaging contrast agents. Adv Sci. 2022;10(1):e2205109. https://doi.org/10.1002/advs.202205109
Luo K, He B, Wu Y, Shen Y, Gu Z. Functional and biodegradable dendritic macromolecules with controlled architectures as nontoxic and efficient nanoscale gene vectors. Biotechnol Adv. 2014;32(4):818–30. https://doi.org/10.1016/j.biotechadv.2013.12.008
Chauhan AS. Dendrimers for drug delivery. Molecules. 2018;23(4):938. https://doi.org/10.3390/molecules23040938
Venditto VJ, Regino CAS, Brechbiel MW. PAMAM dendrimer based macromolecules as improved contrast agents. Mol Pharm. 2005;2(4):302–11. https://doi.org/10.1021/mp050019e
Luo K, Liu G, He B, Wu Y, Gong Q, Song B, et al. Multifunctional gadolinium‐based dendritic macromolecules as liver targeting imaging probes. Biomaterials. 2011;32(10):2575–85. https://doi.org/10.1016/j.biomaterials.2010.12.049
Hankey GJ. Evolution of evidence‐based medicine in stroke. Cerebrovasc Dis. 2021;50(6):644–55. https://doi.org/10.1159/000517679
Li W, Cheng J, He F, Zhang P, Zhang N, Wang J, et al. Cell membrane‐based nanomaterials for theranostics of central nervous system diseases. J Nanobiotechnol. 2023;21(1):276. https://doi.org/10.1186/s12951-023-02004-z
Losseff N, Adams M, Brown MM, Grieve J, Simister R. Stroke and cerebrovascular diseases. Neurology: A Queen Square Textbook. 2016:133–85. https://doi.org/10.1002/9781118486160.ch5
Gao GH, Lee JW, Nguyen MK, Im GH, Yang J, Heo H, et al. pH‐responsive polymeric micelle based on PEG‐poly(β‐amino ester)/(amido amine) as intelligent vehicle for magnetic resonance imaging in detection of cerebral ischemic area. J Contr Release. 2011;155(1):11–7. https://doi.org/10.1016/j.jconrel.2010.09.012
Fagan SC, Nagaraja TN, Fenstermacher JD, Zheng J, Johnson M, Knight RA. Hemorrhagic transformation is related to the duration of occlusion and treatment with tissue plasminogen activator in a nonembolic stroke model. Neurol Res. 2003;25(4):377–82. https://doi.org/10.1179/016164103101201526
Hou W, Jiang Y, Xie G, Zhao L, Zhao F, Zhang X, et al. Biocompatible BSA‐MnO(2) nanoparticles for in vivo timely permeability imaging of blood‐brain barrier and prediction of hemorrhage transformation in acute ischemic stroke. Nanoscale. 2021;13(18):8531–42. https://doi.org/10.1039/d1nr02015c
Zhang P, Feng Y, Zhu L, Xu K, Ouyang Q, Zeng J, et al. Predicting thrombolytic haemorrhage risk of acute ischemic stroke through angiogenesis/inflammation dual‐targeted MR imaging. Nano Today. 2023;48:101707. https://doi.org/10.1016/j.nantod.2022.101707
Björkegren JLM, Lusis AJ. Atherosclerosis: recent developments. Cell. 2022;185(10):1630–45. https://doi.org/10.1016/j.cell.2022.04.004
Ruehm SG, Corot C, Vogt P, Kolb S, Debatin JF. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation. 2001;103(3):415–22. https://doi.org/10.1161/01.cir.103.3.415
Trivedi R, U‐King‐Im J, Gillard J. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaque. Circulation. 2003;108(19):e140. authorreplye140. https://doi.org/10.1161/01.CIR.0000099904.42881.09
Schmitz SA, Coupland SE, Gust R, Winterhalter S, Wagner S, Kresse M, et al. Superparamagnetic iron oxide‐enhanced MRI of atherosclerotic plaques in Watanabe hereditable hyperlipidemic rabbits. Invest Radiol. 2000;35(8):460–71. https://doi.org/10.1097/00004424-200008000-00002
Zhang R, Lu K, Xiao L, Hu X, Cai W, Liu L, et al. Exploring atherosclerosis imaging with contrast‐enhanced MRI using PEGylated ultrasmall iron oxide nanoparticles. Front Bioeng Biotechnol. 2023;11:1279446. https://doi.org/10.3389/fbioe.2023.1279446
Vazquez‐Prada KX, Lam J, Kamato D, Xu ZP, Little PJ, Ta HT. Targeted molecular imaging of cardiovascular diseases by iron oxide nanoparticles. Arterioscler Thromb Vasc Biol. 2021;41(2):601–13. https://doi.org/10.1161/ATVBAHA.120.315404
Michalska M, Machtoub L, Manthey HD, Bauer E, Herold V, Krohne G, et al. Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule‐1‐specific nanoparticles. Arterioscler Thromb Vasc Biol. 2012;32(10):2350–7. https://doi.org/10.1161/ATVBAHA.112.255224
Wang Y, Chen J, Yang B, Qiao H, Gao L, Su T, et al. In vivo MR and fluorescence dual‐modality imaging of atherosclerosis characteristics in mice using profilin‐1 targeted magnetic nanoparticles. Theranostics. 2016;6(2):272–86. https://doi.org/10.7150/thno.13350
Segers FME, den Adel B, Bot I, van der Graaf LM, van der Veer EP, Gonzalez W, et al. Scavenger receptor‐AI‐targeted iron oxide nanoparticles for in vivo MRI detection of atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2013;33(8):1812–9. https://doi.org/10.1161/ATVBAHA.112.300707
Tu C, Ng TSC, Sohi HK, Palko HA, House A, Jacobs RE, et al. Receptor‐targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques. Biomaterials. 2011;32(29):7209–16. https://doi.org/10.1016/j.biomaterials.2011.06.026
Terashima M, Uchida M, Kosuge H, Tsao PS, Young MJ, Conolly SM, et al. Human ferritin cages for imaging vascular macrophages. Biomaterials. 2011;32(5):1430–7. https://doi.org/10.1016/j.biomaterials.2010.09.029
Nandwana V, Ryoo SR, Kanthala S, McMahon KM, Rink JS, Li Y, et al. High‐density lipoprotein‐like magnetic nanostructures (HDL‐MNS):theranostic agents for cardiovascular disease. Chem Mater. 2017;29(5):2276–82. https://doi.org/10.1021/acs.chemmater.6b05357
Cheng D, Li X, Zhang C, Tan H, Wang C, Pang L, et al. Detection of vulnerable atherosclerosis plaques with a dual‐modal single‐photon‐emission computed tomography/magnetic resonance imaging probe targeting apoptotic macrophages. ACS Appl Mater Interfaces. 2015;7(4):2847–55. https://doi.org/10.1021/am508118x
Werner EJ, Datta A, Jocher CJ, Raymond KN. High‐relaxivity MRI contrast agents: where coordination chemistry meets medical imaging. Angew Chem Int Ed Engl. 2008;47(45):8568–80. https://doi.org/10.1002/anie.200800212
Martínez‐Parra L, Piñol‐Cancer M, Sanchez‐Cano C, Miguel‐Coello AB, Di Silvio D, Gomez AM, et al. A comparative study of ultrasmall calcium carbonate nanoparticles for targeting and imaging atherosclerotic plaque. ACS Nano. 2023;17(14):13811–25. https://doi.org/10.1021/acsnano.3c03523
Zhang L, Xue S, Ren F, Huang S, Zhou R, Wang Y, et al. An atherosclerotic plaque‐targeted single‐chain antibody for MR/NIR‐Ⅱ imaging of atherosclerosis and anti‐atherosclerosis therapy. J Nanobiotechnol. 2021;19(1):296. https://doi.org/10.1186/s12951-021-01047-4
Badimon L, Vilahur G. Thrombosis formation on atherosclerotic lesions and plaque rupture. J Intern Med. 2014;276(6):618–32. https://doi.org/10.1111/joim.12296
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