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Review | Open Access

MarR family proteins sense sulfane sulfur in bacteria

Guanhua Xuan1,2,, Luying Xun1,3( ), Yongzhen Xia1 ( )
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China
State Key Laboratory of Marine Food Processing & Safety Control, Ocean University of China, Qingdao, China
School of Molecular Biosciences, Washington State University, Pullman, Washington, USA

Editor: Cheng‐Cai Zhang, Institute of Hydrobiology, Chinese Academy of Sciences, China

Show Author Information

Abstract

Members of the multiple antibiotic resistance regulator (MarR) protein family are ubiquitous in bacteria and play critical roles in regulating cellular metabolism and antibiotic resistance. MarR family proteins function as repressors, and their interactions with modulators induce the expression of controlled genes. The previously characterized modulators are insufficient to explain the activities of certain MarR family proteins. However, recently, several MarR family proteins have been reported to sense sulfane sulfur, including zero-valent sulfur, persulfide (R-SSH), and polysulfide (R-SnH, n ≥ 2). Sulfane sulfur is a common cellular component in bacteria whose levels vary during bacterial growth. The changing levels of sulfane sulfur affect the expression of many MarR-controlled genes. Sulfane sulfur reacts with the cysteine thiols of MarR family proteins, causing the formation of protein thiol persulfide, disulfide bonds, and other modifications. Several MarR family proteins that respond to reactive oxygen species (ROS) also sense sulfane sulfur, as both sulfane sulfur and ROS induce the formation of disulfide bonds. This review focused on MarR family proteins that sense sulfane sulfur. However, the sensing mechanisms reviewed here may also apply to other proteins that detect sulfane sulfur, which is emerging as a modulator of gene regulation.

Keywords

ROSdisulfide bondcysteine thiolsMarR protein familysulfane sulfur

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mLife
Volume 3 Issue 2,
June 2024
Pages 231-239
DOI: 10.1002/mlf2.12109
Cite this article:
Xuan G, Xun L, Xia Y. MarR family proteins sense sulfane sulfur in bacteria. mLife, 2024, 3(2): 231-239. https://doi.org/10.1002/mlf2.12109

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Received: 09 October 2023
Accepted: 24 December 2023
Published: 15 May 2024
© 2024 The Authors. mLife published by John Wiley & Sons Australia, Ltd on behalf of Institute of Microbiology, Chinese Academy of Sciences.

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