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Original Article | Open Access

Investigation of the systemic inflammatory index as a predictor of downstaging in locally advanced rectal cancer patients with preoperative chemoradiation

Wenxue Zou1, Rui Huang1, Yanfen Zheng1, Chao Liu2, Jujie Sun2( ), Yanlai Sun3( ), Jinbo Yue2 ( )
Department of Graduate, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China
Department of Gastrointestinal Cancer Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China
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Abstract

Objectives

To find the correlations between blood systemic inflammatory biomarkers at three treatment time points and clinical effects of neoadjuvant chemoradiotherapy through a retrospective study.

Methods

In total, 101 patients with locally advanced rectal cancer were included in the current study. Patients were divided into two groups based on the T-downstaging, among which 54 patients had T-downstaging. We used non-parametric tests to compare the differences between the variables in two groups. We carried out a logistic regression analysis to evaluate the predictive value of blood systemic inflammatory biomarkers.

Results

Pre-/nadir/postsystemic immune-inflammation, nadir neutrophil-to-lymphocyte ratio, nadir/post-platelet-to-lymphocyte ratio, and post-lymphocyte have differences between groups (p ≤ 0.05 for all). We included p < 0.05 indicators and clinical related factors into the multivariate analysis, respectively, and we found that lower presystemic immune-inflammation, nadir systemic immune-inflammation/neutrophil-to-lymphocyte ratio/post-lymphocyte, and post-nadir/post-platelet-to-lymphocyte ratio were associated with better therapeutic effects (p < 0.05).

Conclusions

The systemic inflammatory index was indicative in predicting the therapeutic effects of locally advanced rectal cancer patients after neoadjuvant chemoradiotherapy.

Keywords

biomarkerschemoradiotherapyrectal cancerinflammatory factors

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Precision Radiation Oncology
Volume 6 Issue 1,
March 2022
Pages 32-38
DOI: 10.1002/pro6.1145
Cite this article:
Zou W, Huang R, Zheng Y, et al. Investigation of the systemic inflammatory index as a predictor of downstaging in locally advanced rectal cancer patients with preoperative chemoradiation. Precision Radiation Oncology, 2022, 6(1): 32-38. https://doi.org/10.1002/pro6.1145

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Received: 29 December 2021
Revised: 06 February 2022
Accepted: 08 February 2022
Published: 03 March 2022
© 2022 The Authors. Precision Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Shandong Cancer Hospital & Institute.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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