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Original Article | Open Access

Incidence and predictive factors of radiation-induced hypothyroidism in breast cancer patients who receive supraclavicular lymph nodes irradiation: A prospective study

Monika Youssef ( ), Caroline Elmaraghi, Tarek Kamel, Mahmoud El-Leithy, Khaled Abdelhakim
Department of Oncology and Nuclear Medicine, Ain Shams University Faculty of Medicine, Cairo, Egypt
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Abstract

Purpose

This paper aimed to assess the incidence of radiotherapy-induced hypothyroidism (RIHT) in breast cancer patients and correlate it with different factors.

Methods

Patients with nonmetastatic breast cancer who received supraclavicular lymph node irradiation as a part of adjuvant radiotherapy from October 2019 to July 2020 were recruited and followed up for 18 months. All patients underwent three-dimensional conformal radiotherapy and underwent computed tomography simulation. The levels of serum thyroid-stimulating hormone (TSH), free triiodothyronine and free thyroxine levels were assessed at baseline (before starting radiotherapy) and 9,12, and 18 months after radiotherapy using immunochemilluminescence. Univariate and multivariate analyses were performed to identify significant factors associated with developing hypothyroidism.

Results

Twenty patients out of 96 (20.8%) developed hypothyroidism. Baseline TSH (cutoff value > 1.42 μIU/ml) was significantly correlated with hypothyroidism.

Conclusion

Routine thyroid function tests assessment is recommended for all breast cancer patients at baseline and after radiotherapy.

Keywords

breast cancerradiation therapyhypothyroidismsupraclavicular lymph nodesthyroid-stimulating hormone

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Precision Radiation Oncology
Volume 6 Issue 4,
December 2022
Pages 298-305
DOI: 10.1002/pro6.1182
Cite this article:
Youssef M, Elmaraghi C, Kamel T, et al. Incidence and predictive factors of radiation-induced hypothyroidism in breast cancer patients who receive supraclavicular lymph nodes irradiation: A prospective study. Precision Radiation Oncology, 2022, 6(4): 298-305. https://doi.org/10.1002/pro6.1182

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Received: 12 September 2022
Revised: 23 November 2022
Accepted: 30 November 2022
Published: 17 December 2022
© 2022 The Authors. Precision Radiation Oncology published by John Wiley & Sons Australia, Ltd on behalf of Shandong Cancer Hospital & Institute.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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