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Review | Open Access

Precision radiotherapy for nasopharyngeal carcinoma

Zhenyu Zhang, Xiangzhou Chen, Taize Yuan ( )
Department of Radiation Oncology, Guangzhou Concord Cancer Center, Guangzhou, Guangdong, China
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Abstract

Nasopharyngeal carcinoma(NPC) occurs frequently in Southern China, and radiotherapy is the main treatment method. At present, intensity-modulated radiotherapy is widely used, which has improved efficacy in patients with NPC and reduced toxicity and side effects. Recently, helical tomography radiotherapy, proton radiotherapy, carbon particle radiotherapy, and other radiotherapy techniques have been used for the clinical treatment of NPC. Individualized nasopharyngeal cancer targets have also been explored. This paper reviews the research progress in radiotherapy techniques and target volume for NPC

Keywords

nasopharyngeal carcinomaprogressionprecision radiotherapytarget volume

References

1

Tang LQ, Li CF, Li J, et al. Establishment and Validation of Prognostic Nomograms for Endemic Nasopharyngeal Carcinoma. J Natl Cancer Inst. 2016;108(1):djv291.
Crossref Google Scholar
2

Chen YP, Chan A, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394(10192):64-80.
Crossref Google Scholar
3

Tao HY, Zhan ZJ, Qiu WZ, et al. Clinical value of docetaxel plus cisplatin (TP) induction chemotherapy followed by TP concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma. J Cancer. 2021;12(1):18-27.
Crossref Google Scholar
4

Peng G, Wang T, Yang KY, et al. A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol. 2012;104(3):286-293.
Crossref Google Scholar
5

Liao S, Xie Y, Feng Y, et al. Superiority of intensity-modulated radiation therapy in nasopharyngeal carcinoma with skull-base invasion. J Cancer Res Clin Oncol. 2020;146(2):429-439.
Crossref Google Scholar
6

Fang FM, Chien CY, Tsai WL, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. Int J Radiat Oncol Biol Phys. 2008;72(2):356-364.
Crossref Google Scholar
7

Moon SH, Cho KH, Lee CG, et al. IMRT vs. 2D-radiotherapy or 3D-conformal radiotherapy of nasopharyngeal carcinoma : Survival outcome in a Korean multi-institutional retrospective study (KROG 11-06). Strahlenther Onkol. 2016;192(6):377-385.
Crossref Google Scholar
8

He L, Xiao J, Wei Z, et al. Toxicity and dosimetric analysis of nasopharyngeal carcinoma patients undergoing radiotherapy with IMRT or VMAT: A regional center’s experience. Oral Oncol. 2020;109:104978.
Crossref Google Scholar
9

Chen BB, Huang SM, Xiao WW, et al. Prospective matched study on comparison of volumetric-modulated arc therapy and intensity-modulated radiotherapy for nasopharyngeal carcinoma: dosimetry, delivery efficiency and outcomes. J Cancer. 2018;9(6):978-986.
Crossref Google Scholar
10

Huang TL, Tsai MH, Chuang HC, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinoma treated by volumetric-modulated arc therapy versus intensity-modulated radiotherapy. Radiat Oncol. 2020;15(1):84.
Crossref Google Scholar
11

Lu S, Fan H, Hu X, et al. Dosimetric Comparison of Helical Tomotherapy, Volume-Modulated Arc Therapy, and Fixed-Field Intensity-Modulated Radiation Therapy in Locally Advanced Nasopharyngeal Carcinoma. Front Oncol. 2021;11:764946.
Crossref Google Scholar
12

Du L, Zhang XX, Feng LC, et al. Treatment of nasopharyngeal carcinoma using simultaneous modulated accelerated radiation therapy via helical tomotherapy: a phase Ⅱ study. Radiol Oncol. 2016;50(2):218-225.
Crossref Google Scholar
13

Wang YC, Li CC, Chien CR. Effectiveness of tomotherapy vs linear accelerator image-guided intensity-modulated radiotherapy for localized pharyngeal cancer treated with definitive concurrent chemoradiotherapy: a Taiwanese population-based propensity score-matched analysis. Br J Radiol. 2018;91(1086):20170947.
Crossref Google Scholar
14

Hu M, Jiang L, Cui X, Zhang J, Yu J. Proton beam therapy for cancer in the era of precision medicine. J Hematol Oncol. 2018;11(1):136.
Crossref Google Scholar
15

Yuan TZ, Zhan ZJ, Qian CN. New frontiers in proton therapy: applications in cancers. Cancer Commun (Lond). 2019;39(1):61.
Crossref Google Scholar
16

Lewis GD, Holliday EB, Kocak-Uzel E, et al. Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes. Head Neck. 2016;38(Suppl 1):E1886-E1895.
Crossref Google Scholar
17

Jiří K, Vladimír V, Michal A, et al. Proton pencil-beam scanning radiotherapy in the treatment of nasopharyngeal cancer: dosimetric parameters and 2-year results. Eur Arch Otorhinolaryngol. 2021;278(3):763-769.
Crossref Google Scholar
18

Li X, Kitpanit S, Lee A, et al. Toxicity Profiles and Survival Outcomes Among Patients With Nonmetastatic Nasopharyngeal Carcinoma Treated With Intensity-Modulated Proton Therapy vs Intensity-Modulated Radiation Therapy. JAMA Netw Open. 2021;4(6):e2113205.
Crossref Google Scholar
19

Lee A, Kitpanit S, Chilov M, Langendijk JA, Lu J, Lee NY. A Systematic Review of Proton Therapy for the Management of Nasopharyngeal Cancer. Int J Part Ther. 2021;8(1):119-130.
Crossref Google Scholar
20

Dionisi F, Croci S, Giacomelli I, et al. Clinical results of proton therapy reirradiation for recurrent nasopharyngeal carcinoma. Acta Oncol. 2019;58(9):1238-1245.
Crossref Google Scholar
21

Durante M, Orecchia R, Loeffler JS. Charged-particle therapy in cancer: clinical uses and future perspectives. Nat Rev Clin Oncol. 2017;14(8):483-495.
Crossref Google Scholar
22

Wang L, Hu J, Liu X, Wang W, Kong L, Lu JJ. Intensity-modulated carbon-ion radiation therapy versus intensity-modulated photon-based radiation therapy in locally recurrent nasopharyngeal carcinoma: a dosimetric comparison. Cancer Manag Res. 2019;11:7767-7777.
Crossref Google Scholar
23

Hu J, Huang Q, Gao J, et al. Mixed Photon and Carbon-Ion Beam Radiotherapy in the Management of Non-Metastatic Nasopharyngeal Carcinoma. Front Oncol. 2021;11:653050.
Crossref Google Scholar
24

Hu J, Huang Q, Gao J, et al. Clinical outcomes of carbon-ion radiotherapy for patients with locoregionally recurrent nasopharyngeal carcinoma. Cancer. 2020;126(23):5173-5183.
Crossref Google Scholar
25

Yang HR, Chen X, Lin S, et al. Treatment outcomes after reduction of the target volume of intensity-modulated radiotherapy following induction chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: A prospective, multi-center, randomized clinical trial. Radiother Oncol. 2018;126(1):37-42.
Crossref Google Scholar
26

Tang LL, Huang CL, Zhang N, et al. Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial. Lancet Oncol. 2022;23(4):479-490.
Crossref Google Scholar
27

Mao YP, Wang SX, Gao TS, et al. Medial retropharyngeal nodal region sparing radiotherapy versus standard radiotherapy in patients with nasopharyngeal carcinoma: open label, non-inferiority, multicentre, randomised, phase 3 trial. BMJ. 2023;380:e072133.
Crossref Google Scholar
Precision Radiation Oncology
Volume 8 Issue 1,
May 2024
Pages 37-41
DOI: 10.1002/pro6.1219
Cite this article:
Zhang Z, Chen X, Yuan T. Precision radiotherapy for nasopharyngeal carcinoma. Precision Radiation Oncology, 2024, 8(1): 37-41. https://doi.org/10.1002/pro6.1219

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Received: 31 August 2023
Revised: 12 December 2023
Accepted: 04 January 2024
Published: 30 January 2024
© 2024 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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