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Research Article

Person to person droplets transmission characteristics in unidirectional ventilated protective isolation room: The impact of initial droplet size

Caiqing Yang12, Xudong Yang1( ), Bin Zhao1
Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Department of Building Science, Tsinghua University, Beijing 100084, China
Beijing Institute of Architectural Design, Beijing 100045, China
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Abstract

Person to person droplets/particles or contaminant cross transmission is an important issue in ventilated environment, especially in the unidirectional ventilated protective isolation room (UVPIR) where the patient’s immune system is extremely low and easily infected. We simulated the dispersion process of the droplets with initial diameter of 100 μm, 10 μm and gaseous contaminant in unidirectional ventilated protective isolation room and studied the droplets dispersion and cross transmission with different sizes. The droplets with initial size of 100 μm settle out of the coughing jet quickly after coming out from mouth and cannot be carried by the coughing jet to the human thermal plume affecting (HTPA) zone of the susceptible manikin. Hence, the larger droplets disperse mainly in the HTPA zone of the source manikin, and the droplets cross transmission between source manikin and susceptible manikin is very small. The droplets with initial size of 10 μm and gaseous contaminant have similar dispersion but different removal process in the UVPIR. Part of the droplets with initial size of 10 μm and gaseous contaminant that are carried by the higher velocity coughing airflow can enter the HTPA zone of the susceptible manikin and disperse around it. The other part cannot spread to the susceptible manikin’s HTPA zone and mainly spread in the source manikin’s HTPA zone. The results from this study would be useful for UVPIR usage and operation in order to minimize the risk of cross infection.

Keywords

dropletcomputational fluid dynamics (CFD)protective isolationcross transmissionindoor air

References

 
AV Arundel, EM Sterling, JH Biggin, TD Sterling (1986). Indirect health effects of relative humidity in indoor environments. Environment Health Perspective, 65: 351-361.
Crossref Google Scholar
 
RA Barnes, TR Rogers (1989). Control of an outbreak of nosocomial aspergillosis by laminar air-flow isolation. Journal of Hospital Infection, 14: 89-94.
Crossref Google Scholar
 
PS Brachman (1990). Transmission and principles of control. In: GL Mandell, RG Douglas, JE Bennett (eds), Principles and Practice of Infectious Diseases, 3rd edn. New York: Churchill Living Stone, pp. 155-158.
Google Scholar
 
G Cao, PV Nielsen, RL Jensen, P Heiselberg, L Liu, J Heikkinen (2015). Protected zone ventilation and reduced personal exposure to airborne cross-infection. Indoor Air, 25: 307-319.
Crossref Google Scholar
 
CYH Chao, MP Wan (2006). A study of the dispersion of expiratory aerosols in unidirectional downward and ceiling-return type airflows using a multiphase approach. Indoor Air, 16: 296-312.
Crossref Google Scholar
 
CYH Chao, MP Wan, L Morawska, GR Johnson, ZD Ristovski, M Hargreaves, K Mengersen, S Corbett, Y Li, X Xie (2009). Characterization of expiration air jets and droplet size distributions immediately at the mouth opening. Aerosol Science, 40: 122-133.
Crossref Google Scholar
 
C Chen, B Zhao, W Cui, L Dong, N An, X Ouyang (2010). The effectiveness of an air cleaner in controlling droplet/aerosol particle dispersion emitted from a patient's mouth in the indoor environment of dental clinics. Journal of the Royal Society Interface, 7: 1105-1118.
Crossref Google Scholar
 
F Chen, S Yu, A Lai (2006). Modeling particle distribution and deposition in indoor environments with a new drift-flux model. Atmospheric Environment, 40: 357-367.
Crossref Google Scholar
 
R Clift, JR Grace, ME Weber (1978). Bubbles, Drops, and Particles. New York: Academic Press.
 
JP Duguid (1946). The size and duration of air carriage of respiratory droplets and droplet nuclei. Journal of Hygiene, 44: 471-479.
Crossref Google Scholar
 
FLUENT (2005). FLUENT Version 6.2. Fluent Inc.
 
P Gastmeier, AC Breier, C Brandt (2012). Influence of laminar airflow on prosthetic joint infections: A systematic review. Journal of Hospital Infection, 81: 73-78.
Crossref Google Scholar
 
GB 50457-2008 (2009). Code for design of pharmaceutical industry clean room. Beijing: China Planning Press. (in Chinese)
 
FP Gregory, RM Marghi, TW Willianm (2007). Potential for airborne contamination in turbulent-and unidirectional-airflow compounding aseptic isolators. American Journal of Health-System Pharmacy, 64: 622-631.
Crossref Google Scholar
 
JK Gupta, CH Lin, Q Chen (2009). Flow dynamics and characterization of a cough. Indoor Air, 19: 517-525.
Crossref Google Scholar
 
JK Gupta, CH Lin, Q Chen (2010). Characterizing exhaled airflow from breathing and talking. Indoor Air, 20: 31-39.
Crossref Google Scholar
 
C Habchi, K Ghali, N Ghaddar (2014). A simplified mathematical model for predicting cross contamination in displacement ventilation air-conditioned space. Journal of Aerosol Science, 76: 72-86.
Crossref Google Scholar
 
C Habchi, K Ghali, N Ghaddar, W Chakroun, S Alotaibi (2016). Ceiling personalized ventilation combined with desk fans for reduced direct and indirect cross-contamination and efficient use of office space. Energy Conversion and Management, 111: 158-173.
Crossref Google Scholar
 
Q He, J Niu, N Gao, T Zhu, T Wu (2011). CFD study of exhaled droplet transmission between occupants under different ventilation strategies in a typical office room. Building and Environment, 46: 397-408.
Crossref Google Scholar
 
M James, WS Khan, MR Nannaparaju, JS Bhamra, R Morgan-Jones (2015). Current evidence for the use of laminar flow in reducing infection rates in total joint arthroplasty. The Open Orthopaedics Journal, 9: 495-498.
Crossref Google Scholar
 
X Li, J Niu, N Gao (2011). Spatial distribution of human respiratory droplet residuals and exposure risk for the co-occupant under different ventilation methods. HVAC&R Research, 17: 432-445.
Google Scholar
 
Y Li, GM Leung, JW Tang, X Yang, CYH Chao, JZ Lin, JW Lu, PV Nielsen, J Niu, H Qian (2007). Role of ventilation in airborne transmission of infectious agents in the built environment—A multidisciplinary systematic review. Indoor Air, 17: 2-18.
Crossref Google Scholar
 
WG Lindsley, FM Blachere, RE Thewlis, A Vishnu, KA Davis, G Cao, JE Palmer, KE Clark, MA Fisher, R Khakoo (2010). Measurements of airborne influenza virus in aerosol particles from human coughs. PLoS ONE, 5(11): e15100.
Crossref Google Scholar
 
ER McFadden, BM Pichurko, HF Bowman, E Ingenito, S Burns, N Dowling, J Solway (1985). Thermal mapping of the airways in humans. Journal of Applied Physiology, 58: 564-570.
Crossref Google Scholar
 
SM McHugh, ADK Hill, H Humphreys (2015). Laminar airflow and the prevention of surgical site infection. More harm than good? The Surgeon, 13: 52-58.
Crossref Google Scholar
 
PV Nielsen, I Olmedo, M Ruiz de Adana, P Grzelecki (2012). Airborne cross-infection risk between two people standing in surroundings with a vertical temperature gradient. HVAC&R Research, 18: 552-561.
Google Scholar
 
I Olmedo, PV Nielsen, M Ruiz de Adana, RL Jensen (2013). The risk of airborne cross-infection in a room with vertical low-velocity ventilation. Indoor Air, 23: 62-73.
Crossref Google Scholar
 
JR Passweg, PA Rowlings, KA Atkinson, AJ Barrett, RP Gale, A Gratwohl, N Jacobsen, JP Klein, P Ljungman, JA Russell, UW Schaefer, KA Sobocinski, JM Vossen, MJ Zhang, MM Horowitz (1998). Influence of protective isolation on outcome of allogeneic bone marrow transplantation for leukemia. Bone Marrow Transplantation, 21: 1231-1238.
Crossref Google Scholar
 
WE Ranz, WR Marshall Jr (1952). Evaporation from drops, Part 2. Chemical Engineering Progress, 48: 173-180.
Google Scholar
 
RL Riley (1974). Airborne infection. The American Journal of Medicine, 57: 466-475.
Crossref Google Scholar
 
A Schlesinger, M Paul, A Gafter-Gvili, B Rubinovitch, L Leibovici (2009). Infection-control interventions for cancer patients after chemotherapy: A systematic review and meta-analysis. The Lancet Infectious Diseases, 9: 97-107.
Crossref Google Scholar
 
R Storb, RL Prentice, CD Buckner, RA Clift, F Appelbaum, J Deeg, K Doney, JA Hansen, M Mason, JE Sanders, J Singer, KM Sullivan, RP Witherspoon,, ED Thomas (1983). Graft versus host disease and survival in patients with aplastic anaemia treated by marrow grafts from HLA-identical siblings-Beneficial effect of a protective environment. The New England Journal of Medicine, 308: 302-307.
Crossref Google Scholar
 
WF Wells (1934). On air-borne infection study: II. Droplets and droplet nuclei. American Journal of Epidemiology, 20: 611-618.
Crossref Google Scholar
 
C Yang, X Yang, B Zhao (2014). Person to person airborne particles cross transmission in vertical laminar air flow room. In: Proceedings of Indoor Air 2014, Hong Kong, China.
 
C Yang, X Yang, B Zhao (2015). The ventilation needed to control thermal plume and particle dispersion from manikins in a unidirectional ventilated protective isolation room. Building Simulation, 8: 551-565.
Crossref Google Scholar
 
ITS Yu, Y Li, TW Wong, W Tam, AT Chan, JHW Lee, DYC Leung, T Ho (2004). Evidence of airborne transmission of the severe acute respiratory syndrome virus. The New England Journal of Medicine, 350: 1731-1739.
Crossref Google Scholar
 
B Zhao, J Wu (2005). Numerical investigation of particle diffusion in a clean room. Indoor and Built Environment, 14: 469-479.
Crossref Google Scholar
 
B Zhao, Y Zhang, X Li, X Yang, DT Huang (2004). Comparison of indoor aerosol particle concentration and deposition in different ventilated rooms by numerical method. Building and Environment, 39: 1-8.
Crossref Google Scholar
Building Simulation
Volume 9 Issue 5,
October 2016
Pages 597-606
DOI: 10.1007/s12273-016-0290-7
Cite this article:
Yang C, Yang X, Zhao B. Person to person droplets transmission characteristics in unidirectional ventilated protective isolation room: The impact of initial droplet size. Building Simulation, 2016, 9(5): 597-606. https://doi.org/10.1007/s12273-016-0290-7

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Received: 14 December 2015
Revised: 26 February 2016
Accepted: 23 March 2016
Published: 11 April 2016
>© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016
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