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Review Article

Glyconanomaterials: Emerging applications in biomedical research

Xuan Chen1Olof Ramström2Mingdi Yan1,2( )
Department of ChemistryUniversity of Massachusetts LowellLowellMA01854USA
Department of ChemistryKTH-Royal Institute of TechnologyStockholm S-10044Sweden
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Graphical Abstract

Abstract

Carbohydrates constitute the most abundant organic matter in nature, serving as structural components and energy sources, and mediating a wide range of cellular activities. The emergence of nanomaterials with distinct optical, magnetic, and electronic properties has witnessed a rapid adoption of these materials for biomedical research and applications. Nanomaterials of various shapes and sizes having large specific surface areas can be used as multivalent scaffolds to present carbohydrate ligands. The resulting glyconanomaterials effectively amplify the glycan-mediated interactions, making it possible to use these materials for sensing, imaging, diagnosis, and therapy. In this review, we summarize the synthetic strategies for the preparation of various glyconanomaterials. Examples are given where these glyconanomaterials have been used in sensing and differentiation of proteins and cells, as well as in imaging glycan-medicated cellular responses.

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Nano Research
Pages 1381-1403
Cite this article:
Chen X, Ramström O, Yan M. Glyconanomaterials: Emerging applications in biomedical research. Nano Research, 2014, 7(10): 1381-1403. https://doi.org/10.1007/s12274-014-0507-y

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Received: 30 March 2014
Revised: 30 May 2014
Accepted: 02 June 2014
Published: 16 August 2014
© Tsinghua University Press and Springer‐Verlag Berlin Heidelberg 2014
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