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Research Article

Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer

Shaoheng Tang, Mei Chen, Nanfeng Zheng( )
State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy Materials, and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen University, XiamenFujian361005China
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Abstract

Near-infrared (NIR) photothermal therapy has developed very quickly in recent years. However, its clinical applications are hindered by many practical problems, such as low accumulation in tumors, high laser power density and high biotoxicity in vivo. Herein, a versatile system combining chemotherapy with photothermal therapy for cancer therapy using ultrasmall Pd nanosheets (SPNS) has been developed. The SPNS can serve as pH-responsive drug carriers to efficiently deliver DOX into cancer cells and tumors. On the other hand, the coordinative loading of DOX on SPNS enhances its accumulation in tumor tissue. So we can efficiently ablate tumor using low-intensity laser radiation. Importantly, with ultrasmall size (~4.4 nm), SPNS surface-functionalized with reduced glutathione (GSH) can be cleared from the body through the renal system into the urine. This cancer therapeutic nanosystem, which exhibits a significant synergistic effect and low systemic toxicity, has great potential for clinical applications.

Keywords

photothermal therapychemotherapyPd nanosheetsdrug deliverysynergistic effect

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Nano Research
Volume 8 Issue 1,
January 2015
Pages 165-174
DOI: 10.1007/s12274-014-0605-x
Cite this article:
Tang S, Chen M, Zheng N. Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer. Nano Research, 2015, 8(1): 165-174. https://doi.org/10.1007/s12274-014-0605-x
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Received: 28 August 2014
Revised: 30 September 2014
Accepted: 02 October 2014
Published: 16 December 2014
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014
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