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Review Article

Recent advances in the development of organic photothermal nano-agents

Xuejiao Song, Qian Chen, Zhuang Liu( )
Institute of Functional Nano & Soft Materials (FUNSOM)Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou215123China
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Graphical Abstract

Abstract

Recently, photothermal therapy (PTT) has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared (NIR) light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nanoagents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.

Keywords

photothermal therapynear-infraredorganic nanomaterials

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Nano Research
Volume 8 Issue 2,
February 2015
Pages 340-354
DOI: 10.1007/s12274-014-0620-y
Cite this article:
Song X, Chen Q, Liu Z. Recent advances in the development of organic photothermal nano-agents. Nano Research, 2015, 8(2): 340-354. https://doi.org/10.1007/s12274-014-0620-y
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Received: 16 September 2014
Revised: 16 October 2014
Accepted: 20 October 2014
Published: 21 November 2014
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014
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