AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
The conversion of electromagnetic energy into heat by nanomagnets has the potential to be a powerful, non-invasive technique for cancer therapy by hyperthermia and hyperthermia-based drug release, while temperature controllability and targeted heating are challenges to developing applications of such magnetic inductive hyperthermia. This study was designed to control the hyperthermia position and area using a combination of alternating current (AC) and a static magnetic field. MnZn ferrite (MZF) nanoparticles which exhibited excellent hyperthermia properties were first prepared and characterized as an inductive heating mediator. We built model static magnetic fields simply using a pair of permanent magnets and studied the static magnetic field distributions by measurements and numerical simulations. The influence of the transverse static magnetic fields on hyperthermia properties was then investigated on MZF magnetic fluid, gel phantoms and SMMC-7721 cells in vitro. The results showed a static magnetic field can inhibit the temperature rise of MZF nanoparticles in an AC magnetic field. But in the uneven static magnetic field formed by a magnet pair with repelling poles face-to-face, the heating area can be restricted in a central low static field; meanwhile the side effects of hyperthermia can be reduced by a surrounding high static field. As a result we can position the hyperthermia area, protect the non-therapeutic area, and reduce the side effects just by using a well-designed combination of AC and static field.
Jordan, A.; Wust, P.; Fähling, H.; John, W.; Hinz, A.; Felix, R. Inductive heating of ferrimagnetic particles and magnetic fluids: Physical evaluation of their potential for hyperthermia. Inter. J. Hyperthermia 2009, 25, 499-511.
Jordan, A.; Scholz, R.; Wust, P.; Fähling, H.; Felix, R. Magnetic fluid hyperthermia (mfh): Cancer treatment with ac magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J. Magn. Magn. Mater. 1999, 201, 413-419.
Mohr, R.; Kratz, K.; Weigel, T.; Lucka-Gabor, M.; Moneke, M.; Lendlein, A. Initiation of shape-memory effect by inductive heating of magnetic nanoparticles in thermoplastic polymers. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 3540-3545.
Hergt, R.; Dutz, S.; Müller, R.; Zeisberger, M. Magnetic particle hyperthermia: Nanoparticle magnetism and materials development for cancer therapy. J. Phys. : Conden. Matter 2006, 18, S2919-S2934.
Kumar, C. S. S. R.; Mohammad, F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv. Drug Delivery Rev. 2011, 63, 789-808.
Wust, P.; Hildebrandt, B.; Sreenivasa, G.; Rau, B.; Gellermann, J.; Riess, H.; Felix, R.; Schlag, P. M. Hyperthermia in combined treatment of cancer. Lancet Oncol. 2002, 3, 487-497.
Hayash, K.; Nakamura, M.; Sakamoto, W.; Yogo, T.; Miki, H.; Ozaki, S.; Abe, M.; Matsumoto, T.; Ishimura, K. Superparamagnetic nanoparticle clusters for cancer theranostics combining magnetic resonance imaging and hyperthermia treatment. Theranostics 2013, 3, 366-376.
Fortin, J. -P.; Wilhelm, C.; Servais, J.; Ménager, C.; Bacri, J. -C.; Gazeau, F. Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J. Am. Chem. Soc. 2007, 129, 2628.
Cantillon-Murphy, P.; Wald, L. L.; Adalsteinsson, E.; Zahn, M. Heating in the MRI environment due to superparamagnetic fluid suspensions in a rotating magneticfield. J. Magn. Magn. Mater. 2010, 322, 727-733.
Mehdaoui, B.; Carrey, J.; Stadler, M.; Cornejo, A.; Nayral, C.; Delpech, F.; Chaudret, B.; Respaud, M. Influence of a transverse static magnetic field on the magnetic hyperthermia properties and high-frequency hysteresis loops of ferromagnetic feco nanoparticles. Appl. Phys. Lett. 2012, 100, 052403.
Déjardin, P. M.; Kalmykov, Y. P.; Kashevsky, B. E.; EI Mrabti, H.; Poperechny, I. S.; Raikher, Y. L.; Titov, S. V. Effect of a dc bias field on the dynamic hysteresis of single-domain ferromagnetic particles. J. Appl. Phys. 2010, 107, 073914.
Jackson, J. D. Classical Electrodynamics; John Wiley and Sons, Inc. : New York, 1999.
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
Sun, S.; Zeng, H.; Robinson, D. B.; Raoux, S.; Rice, P. M.; Wang, S. X.; Li, G. Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J. Am. Chem. Soc. 2004, 126, 273-279.
Kim, T.; Shima, M. Reduced magnetization in magnetic oxide nanoparticles. J. Appl. Phys. 2007, 101, 09M516.
Yan, A.; Liu, X.; Yi, R.; Shi, R.; Zhang, N.; Qiu, G. Selective synthesis and properties of monodisperse zn ferrite hollow nanospheres and nanosheets. J. Phys. Chem. C 2008, 112, 8558-8563.
Duffy, J. A.; Taylor, J. W.; Dugdale, S. B.; Shenton-Taylor, C.; Butchers, M. W.; Giblin, S. R.; Cooper, M. J.; Sakurai, Y.; Itou, M. Spin and orbital moments in Fe3O4. Phys. Rev. B 2010, 81, 134424.
Mehdaoui, B.; Carrey, J.; Stadler, M.; Cornejo, A.; Nayral, C.; Delpech, F.; Chaudret, B.; Respaud, M. Influence of a transverse static magnetic field on the magnetic hyperthermia properties and high-frequency hysteresis loops of ferromagnetic feco nanoparticles. Appl. Phys. Lett. 2012, 100, 052403.
Wertheim, G. K.; Butler, M. A.; West, K. W.; Buchanan, D. N. E. Determination of the gaussian and lorentzian content of experimental line shapes. Rev. Sci. Instrum. 1974, 45, 1369-1371.
京公网安备11010802044758号