AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéli-phase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit > 98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.
Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics, 2013. CA-Cancer J. Clin. 2013, 63, 11–30.
Kumar, C. Nanomaterials for Cancer Diagnosis; Wiley-VCH: Weinheim, 2007.
Song, X. J.; Chen, Q.; Liu, Z. Recent advances in the development of organic photothermal nano-agents. Nano Res. 2015, 8, 340–354.
Xia, Y. N.; Li, W. Y.; Cobley, C. M.; Chen, J. Y.; Xia, X. H.; Zhang, Q.; Yang, M. X.; Cho, E. C.; Brown, P. K. Gold nanocages: From synthesis to theranostic applications. Acc. Chem. Res. 2011, 44, 914–924.
Kim, J. W.; Galanzha, E. I.; Shashkov, E. V.; Moon, H. M.; Zharov, V. P. Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents. Nat. Nanotechnol. 2009, 4, 688–694.
Liu, Y.; Yin, J. J.; Nie, Z. H. Harnessing the collective properties of nanoparticle ensembles for cancer theranostics. Nano Res. 2014, 7, 1719–1730.
Gobin, A. M.; Lee, M. H.; Halas, N. J.; James, W. D.; Drezek, R. A.; West, J. L. Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy. Nano Lett. 2007, 7, 1929–1934.
Tang, S. H.; Chen, M.; Zheng, N. F. Multifunctional ultrasmall Pd nanosheets for enhanced near-infrared photothermal therapy and chemotherapy of cancer. Nano Res. 2015, 8, 165–174.
Wang, Y. C.; Black, K. C. L.; Luehmann, H.; Li, W. Y.; Zhang, Y.; Cai, X.; Wan, D. H.; Liu, S. Y.; Li, M.; Kim, P. et al. Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. ACS Nano 2013, 7, 2068–2077.
Rai, P.; Mallidi, S.; Zheng, X.; Rahmanzadeh, R.; Mir, Y.; Elrington, S.; Khurshid, A.; Hasan, T. Development and applications of photo-triggered theranostic agents. Adv. Drug Deliver. Rev. 2010, 62, 1094–1124.
Terentyuk, G.; Panfilova, E.; Khanadeev, V.; Chumakov, D.; Genina, E.; Bashkatov, A.; Tuchin, V.; Bucharskaya, A.; Maslyakova, G.; Khlebtsov, N. et al. Gold nanorods with a hematoporphyrin-loaded silica shell for dual-modality photodynamic and photothermal treatment of tumors in vivo. Nano Res. 2014, 7, 325–337.
Li, N.; Zhao, P. X.; Astruc, D. Anisotropic gold nanoparticles: Synthesis, properties, applications, and toxicity. Angew. Chem., Int. Ed. 2014, 53, 1756–1789.
Cho, E. C.; Zhang, Y.; Cai, X.; Moran, C. M.; Wang, L. V.; Xia, Y. N. Quantitative analysis of the fate of gold nanocages in vitro and in vivo after uptake by U87-MG tumor cells. Angew. Chem., Int. Edit. 2013, 52, 1152–1155.
Vigderman, L.; Zubarev, E. R. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules. Adv. Drug Deliver. Rev. 2013, 65, 663–676.
Cho, E. C.; Zhang, Q.; Xia, Y. N. The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles. Nat. Nanotechnol. 2011, 6, 385–391.
Feng, L. Y.; Wu, L.; Qu, X. G. New horizons for diagnostics and therapeutic applications of graphene and graphene oxide. Adv. Mater. 2013, 25, 168–186.
Yang, K.; Feng, L. Z.; Shi, X. Z.; Liu, Z. Nano-graphene in biomedicine: Theranostic applications. Chem. Soc. Rev. 2013, 42, 530–547.
Yang, Y. Q.; Asiri, A. M.; Tang, Z. W.; Du, D.; Lin, Y. H. Graphene based materials for biomedical applications. Mater. Today 2013, 16, 365–373.
Yin, W. Y.; Yan, L.; Yu, J.; Tian, G.; Zhou, L. J.; Zheng, X. P.; Zhang, X.; Yong, Y.; Li, J.; Gu, Z. J. et al. High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. ACS Nano 2014, 8, 6922–6933.
Cheng, L.; Liu, J. J.; Gu, X.; Gong, H.; Shi, X. Z.; Liu, T.; Wang, C.; Wang, X. Y.; Liu, G.; Xing, H. Y. et al. PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater. 2014, 26, 1886–1893.
Tian, Q. W.; Tang, M. H.; Sun, Y. G.; Zou, R. J.; Chen, Z. G.; Zhu, M. F.; Yang, S. P.; Wang, J. L.; Wang, J. H.; Hu, J. Q. Hydrophilic flower-like CuS superstructures as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells. Adv. Mater. 2011, 23, 3542–3547.
Zhang, Y.; Zhang, Y. J.; Hong, G. S.; He, W.; Zhou, K.; Yang, K.; Li, F.; Chen, G. C.; Liu, Z.; Dai, H. J. et al. Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice. Biomaterials 2013, 34, 3639–3646.
Li, J.; Jiang, F.; Yang, B.; Song, X. R.; Liu, Y.; Yang, H. H.; Cao, D. R.; Shi, W. R.; Chen, G. N. Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy. Sci. Rep. 2013, 3, 1998.
Hessel, C. M.; Pattani, V. P.; Rasch, M.; Panthani, M. G.; Koo, B.; Tunnell, J. W.; Korgel, B. A. Copper selenide nanocrystals for photothermal therapy. Nano Lett. 2011, 11, 2560–2566.
Seabra, A. B.; Paula, A. J.; de Lima, R.; Alves, O. L.; Durán, N. Nanotoxicity of graphene and graphene oxide. Chem. Res. Toxicol. 2014, 27, 159–168.
Xu, L. G.; Cheng, L.; Wang, C.; Peng, R.; Liu, Z. Conjugated polymers for photothermal therapy of cancer. Polym. Chem. 2014, 5, 1573–1580.
Yang, J.; Choi, J.; Bang, D.; Kim, E.; Lim, E. K.; Park, H.; Suh, J. S.; Lee, K.; Yoo, K. H.; Kim, E. K. et al. Convertible organic nanoparticles for near-infrared photothermal ablation of cancer cells. Angew. Chem., Int. Ed. 2011, 50, 441–444.
Yang, K.; Xu, H.; Cheng, L.; Sun, C. Y.; Wang, J.; Liu, Z. In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles. Adv. Mater. 2012, 24, 5586–5592.
Zha, Z. B.; Yue, X. L.; Ren, Q. S.; Dai, Z. F. Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells. Adv. Mater. 2013, 25, 777–782.
Chen, X. B.; Li, C.; Grätzel, M.; Kostecki, R.; Mao, S. S. Nanomaterials for renewable energy production and storage. Chem. Soc. Rev. 2012, 41, 7909–7937.
Liu, G.; Yang, H. G.; Pan, J.; Yang, Y. Q.; Lu, G. Q.; Cheng, H. M. Titanium dioxide crystals with tailored facets. Chem. Rev. 2014, 114, 9559–9612.
Shrestha, N. K.; Macak, J. M.; Schmidt-Stein, F.; Hahn, R.; Mierke, C. T.; Fabry, B.; Schmuki, P. Magnetically guided titania nanotubes for site-selective photocatalysis and drug release. Angew. Chem., Int. Ed. 2009, 48, 969–972.
Song, Y. Y.; Schmidt-Stein, F.; Bauer, S.; Schmuki, P. Amphiphilic TiO2 nanotube arrays: An actively controllable drug delivery system. J. Am. Chem. Soc. 2009, 131, 4230– 4232.
Brunette, D. M.; Tengvall, P.; Textor, M.; Thomsen, P. Titanium in Medicine; Springer: Berlin, 2001.
Kwon, D. H.; Kim, K. M.; Jang, J. H.; Jeon, J. M.; Lee, M. H.; Kim, G. H.; Li, X. S.; Park, G. S.; Lee, B.; Han, S. et al. Atomic structure of conducting nanofilaments in TiO2 resistive switching memory. Nat. Nanotechnol. 2010, 5, 148–153.
Ohkoshi, S.; Tsunobuchi, Y.; Matsuda, T.; Hashimoto, K.; Namai, A.; Hakoe, F.; Tokoro, H. Synthesis of a metal oxide with a room-temperature photoreversible phase transition. Nat. Chem. 2010, 2, 539–545.
Myung, S. T.; Kikuchi, M.; Yoon, C. S.; Yashiro, H.; Kim, S. J.; Sun, Y. K.; Scrosati, B. Black anatase titania enabling ultra high cycling rates for rechargeable lithium batteries. Energy Environ. Sci. 2013, 6, 2609–2614.
Portehault, D.; Maneeratana, V.; Candolfi, C.; Deschler, N.; Veremchuk, I.; Grin, Y.; Sanchez, C.; Antonietti, M. Facile general route toward tunable magnéli nanostructures and their use as thermoelectric metal oxide/carbon nanocomposites. ACS Nano 2011, 5, 9052–9061.
Chen, X. B.; Liu, L.; Yu, P. Y.; Mao, S. S. Increasing solar absorption for photocatalysis with black hydrogenated titanium dioxide nanocrystals. Science 2011, 331, 746–750.
Tominaka, S.; Tsujimoto, Y.; Matsushita, Y.; Yamaura, K. Synthesis of nanostructured reduced titanium oxide: Crystal structure transformation maintaining nanomorphology. Angew. Chem., Int. Ed. 2011, 50, 7418–7421.
Zhou, S. Q.; Čižmár, E.; Potzger, K.; Krause, M.; Talut, G.; Helm, M.; Fassbender, J.; Zvyagin, S. A.; Wosnitza, J.; Schmidt, H. Origin of magnetic moments in defective TiO2 single crystals. Phys. Rev. B 2009, 79, 113201.
Wang, Z.; Yang, C. Y.; Lin, T. Q.; Yin, H.; Chen, P.; Wan, D. Y.; Xu, F. F.; Huang, F. Q.; Lin, J. H.; Xie, X. M. et al. Visible-light photocatalytic, solar thermal and photoelectrochemical properties of aluminium-reduced black titania. Energy Environ. Sci. 2013, 6, 3007–3014.
Liu, G.; Yin, L. C.; Wang, J. Q.; Niu, P.; Zhen, C.; Xie, Y. P.; Cheng, H. M. A red anatase TiO2 photocatalyst for solar energy conversion. Energy Environ. Sci. 2012, 5, 9603–9610.
Khan, Z.; Khannam, M.; Vinothkumar, N.; De, M.; Qureshi, M. Hierarchical 3D NiO-CdS heteroarchitecture for efficient visible light photocatalytic hydrogen generation. J. Mater. Chem. 2012, 22, 12090–12095.
Wang, Z.; Yang, C. Y.; Lin, T. Q.; Yin, H.; Chen, P.; Wan, D. Y.; Xu, F. F.; Huang, F. Q.; Lin, J. H.; Xie, X. M. et al. H-doped black titania with very high solar absorption and excellent photocatalysis enhanced by localized surface plasmon resonance. Adv. Funct. Mater. 2013, 23, 5444–5450.
Wei, S. H.; Wu, R.; Jian, J. K.; Chen, F. J.; Sun, Y. F. Black and yellow anatase titania formed by (H, N)-doping: Strong visible-light absorption and enhanced visible-light photocatalysis. Dalton Trans. 2015, 44, 1534–1538.
Ou, G.; Li, D. K.; Pan, W.; Zhang, Q. H.; Xu, B.; Gu, L.; Nan, C. W.; Wu, H. Arc-melting to narrow the bandgap of oxide semiconductors. Adv. Mater. 2015, 27, 2589–2594.
京公网安备11010802044758号