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Research Article

Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

Geonwook Yoo1,§, Heekyeong Park2,§, Minjung Kim2,§, Won Geun Song2, Seokhwan Jeong2, Min Hyung Kim3, Hyungbeen Lee3, Sang Woo Lee3, Young Ki Hong2, Min Goo Lee4, Sungho Lee4(), Sunkook Kim2()
School of Electronic Engineering Soongsil University Seoul 06978 Republic of Korea
Multi-Functional Nano/Bio Electronics Lab. Kyung Hee University Gyeonggi 17104 Republic of Korea
Department of Biomedical Engineering Yonsei University Wonju 26493 Republic of Korea
Korea Electronics Technology InstituteGyeonggi 13488 Republic of Korea

§ These authors contributed equally to this work.

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An erratum to this article is available online at:
https://doi.org/10.1007/s12274-017-1499-1

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Abstract

Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL-1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2-3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.

Keywords

epidermal skin biomarkerMoS2biosensorreal-timepoint-of-care diagnostics

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Nano Research
Volume 10 Issue 3,
March 2017
Pages 767-775
DOI: 10.1007/s12274-016-1289-1
Cite this article:
Yoo G, Park H, Kim M, et al. Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics. Nano Research, 2017, 10(3): 767-775. https://doi.org/10.1007/s12274-016-1289-1
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