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Research Article

A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells

Jichuan Qiu1,2,§, Kun Zhao1,§, Linlin Li1,§, Xin Yu1, Weibo Guo1, Shu Wang1, Xiaodi Zhang1, Caofeng Pan1( ), Zhong Lin Wang1 ( ), Hong Liu2 ( )
Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences; National Center for Nanoscience and Technology (NCNST) Beijing 100083 China
Bio-Micro-Nano Functional Materials Center State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

§ These authors contributed equally to this work.

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Graphical Abstract

Abstract

Nanomaterials show promising opportunities to address clinical problems (such as insufficient capture of circulating tumor cells; CTCs) via the high surface area-to-volume ratio and high affinity for biological cells. However, how to apply these nanomaterials as a nano-bio interface in a microfluidic device for efficient CTC capture with high specificity remains a challenge. In the present work, we first found that a titanium dioxide (TiO2) nanorod array that can be conveniently prepared on multiple kinds of substrates has high affinity for tumor cells. Then, the TiO2 nanorod array was vertically grown on the surface of a microchannel with hexagonally patterned Si micropillars via a hydrothermal reaction, forming a new kind of a micro-nano 3D hierarchically structured microfluidic device. The vertically grown TiO2 nanorod array was used as a sensitive nano-bio interface of this 3D hierarchically structured microfluidic device, which showed high efficiency of CTC capture (76.7% ± 7.1%) in an artificial whole-blood sample.

Keywords

TiO2 nanorod arraycirculating tumor cellmicrofluidic devicenano-bio interface3D hierarchical structure

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Nano Research
Volume 10 Issue 3,
March 2017
Pages 776-784
DOI: 10.1007/s12274-016-1313-5
Cite this article:
Qiu J, Zhao K, Li L, et al. A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells. Nano Research, 2017, 10(3): 776-784. https://doi.org/10.1007/s12274-016-1313-5

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Received: 05 August 2016
Revised: 23 September 2016
Accepted: 01 October 2016
Published: 26 November 2016
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016
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