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Research Article

Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence

Rui Zou1,§, Junjian Huang1,§, Junpeng Shi2, Lin Huang1, Xuejie Zhang1, Ka-Leung Wong3( ), Hongwu Zhang2( ), Dayong Jin4( ), Jing Wang1( ), Qiang Su1
Ministry of Education Key Laboratory of Bioinorganic and Synthetic ChemistryState Key Laboratory of Optoelectronic Materials and TechnologiesKLGHEI of Environment and Energy ChemistrySchool of ChemistrySun Yat-Sen UniversityGuangzhou510275China
Key Lab of Urban Pollutant ConversionInstitute of Urban EnvironmentChinese Academy of SciencesXiamen361021China
Department of ChemistryHong Kong Baptist UniversityHong Kong999077China
Institute for Biomedical Materials and Devices (IBMD)Faculty of ScienceUniversity of Technology SydneyNSW2007Australia

§ These authors contributed equally to this work.

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Graphical Abstract

Abstract

Near-infrared (NIR) persistent-luminescence nanoparticles have emerged as a new class of background-free contrast agents that are promising for in vivo imaging. The next key roadblock is to establish a robust and controllable method for synthesizing monodisperse nanoparticles with high luminescence brightness and long persistent duration. Herein, we report a synthesis strategy involving the coating/etching of the SiO2 shell to obtain a new class of small NIR highly persistent luminescent ZnGa2O4: Cr3+, Sn4+ (ZGOCS) nanoparticles. The optimized ZGOCS nanoparticles have an excellent size distribution of ~15 nm without any agglomeration and an NIR persistent luminescence that is enhanced by a factor of 13.5, owing to the key role of the SiO2 shell in preventing nanoparticle agglomeration after annealing. The ZGOCS nanoparticles have a signal-to-noise ratio ~3 times higher than that of previously reported ZnGa2O4: Cr3+ (ZGC-1) nanoparticles as an NIR persistent-luminescence probe for in vivo bioimaging. Moreover, the persistent-luminescence signal from the ZGOCS nanoparticles can be repeatedly re-charged in situ with external excitation by a white lightemitting diode; thus, the nanoparticles are suitable for long-term in vivo imaging applications. Our study suggests an improved strategy for fabricating novel high-performance optical nanoparticles with good biocompatibility.

Keywords

core-shell structurein vivo imagingnarrow size distributionnear-infrared (NIR) persistent luminescencebiocompatibility

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Nano Research
Volume 10 Issue 6,
June 2017
Pages 2070-2082
DOI: 10.1007/s12274-016-1396-z
Cite this article:
Zou R, Huang J, Shi J, et al. Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence. Nano Research, 2017, 10(6): 2070-2082. https://doi.org/10.1007/s12274-016-1396-z

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Received: 17 October 2016
Revised: 24 November 2016
Accepted: 27 November 2016
Published: 27 January 2017
© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2016
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