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New insight into photoacoustic conversion efficiency by plasmon-mediated nanocavitation: Implications for precision theranostics
Sihua Yang(
), Da Xing()
), Da Xing()Abstract
The probe-assisted integration of imaging and therapy into a single modality offers significant advantages in bio-applications. As a newly developed photoacoustic (PA) mechanism, plasmon-mediated nanocavitation, whereby photons are effectively converted into PA shockwaves, has excellent advantages for image-guided therapy. In this study, by simulating the laser absorption, temperature field, and nanobubble dynamics using both finite-element analysis and computational fluid dynamics, we quantified the cavitation-induced PA conversion efficiency of a water-immersed gold nanosphere, revealing new insights. Interestingly, sequential multi-bubble emission accompanied by high PA signal production occur under a single high-dose pulse of laser irradiation, enabling a cavitation-induced PA conversion efficiency up to 2%, which is ~50 times higher than that due to thermal expansion. The cavitation-induced PA signal has unique frequency characteristics, which may be useful for a new approach for in vivo nanoparticle tracking. Our work offers theoretical guidance for accurate diagnosis and controllable therapy based on plasmon-mediated nanocavitation.
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Pages 2800-2809
Cite this article:
Shi Y, Yang S, Xing D. New insight into photoacoustic conversion efficiency by plasmon-mediated nanocavitation: Implications for precision theranostics. Nano Research, 2017, 10(8): 2800-2809. https://doi.org/10.1007/s12274-017-1483-9
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