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Research Article

Spermine induced reversible collapse of deoxyribonucleic acid-bridged nanoparticle-based assemblies

Kristian L. Göeken1, Richard B. M. Schasfoort1, Vinod Subramaniam1,2, Ron Gill1,3( )
MIRA Institute for Biomedical Technology and Technical MedicineUniversity of TwenteDrienerlolaan5, 7522 NB, Enschedethe Netherlands
Vrije Universiteit AmsterdamDe Boelelaan 1105, 1081 HV, Amsterdamthe Netherlands
Saxion University of Applied SciencesM. H. Tromplaan 28, 7513 AB, Enschedethe Netherlands
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Abstract

DNA-linked 2D and 3D nano-assemblies find use in a diverse set of applications, ranging from DNA-origami in drug delivery and medical imaging, to DNA-linked nanoparticle structures for use in plasmonics and (bio)sensing. However, once these structures have been fully assembled, few options are available to modulate structure geometry. Here, we investigated the use of the polycation spermine to induce DNA collapse in small oligonucleotide-linked (54 bp) gold nanoparticle structures by monitoring shifts in the localized surface plasmon resonance (LSPR) peak and by comparing the data with finite-difference time-domain (FDTD) simulations. Our data shows that low concentrations of spermine can be applied to induce large changes in DNA conformation, leading to a significant reduction in interparticle distance (from ~25 to ~3 nm) and enhanced plasmonic coupling. The DNA collapse is near-instantaneous and reversible, and its application at low and high DNA densities is demonstrated with surface plasmon resonance imaging (SPRi), showing the potential of spermine to dynamically modulate distances and geometry in DNA-based nano-assemblies.

Keywords

nanoparticlessperminedeoxyribonucleic acidlocalized surface plasmon resonancesurface plasmon resonance imaging

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Nano Research
Volume 11 Issue 1,
January 2018
Pages 383-396
DOI: 10.1007/s12274-017-1641-0
Cite this article:
Göeken KL, Schasfoort RBM, Subramaniam V, et al. Spermine induced reversible collapse of deoxyribonucleic acid-bridged nanoparticle-based assemblies. Nano Research, 2018, 11(1): 383-396. https://doi.org/10.1007/s12274-017-1641-0

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Received: 21 November 2016
Revised: 21 April 2017
Accepted: 23 April 2017
Published: 15 August 2017
© Tsinghua University Press and Springer-Verlag GmbH Germany 2017
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