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The accurate detection of blood glucose is of critical importance in the diagnosis and management of diabetes and its complications. Herein, we report a novel strategy based on an upconversion nanoparticles-polydopamine (UCNPs-PDA) nanosystem for the accurate detection of glucose in human serum and whole blood through a simple blending of test samples with ligand-free UCNPs, dopamine, and glucose oxidase (GOx). Owing to the high affinity of lanthanide ions exposed on the surface of ligand-free UCNPs, dopamine monomers could spontaneously attach to the UCNPs and further polymerize to form a PDA shell, resulting in a remarkable upconversion luminescence (UCL) quenching (97.4%) of UCNPs under 980-nm excitation. Such UCL quenching can be effectively inhibited by H2O2 produced from the GOx/glucose enzymatic reaction, thus enabling the detection of H2O2 or glucose based on the UCL quenching/inhibition bioassay. Owing to the highly sensitive UCL response and background-free interference of the UCNPs-PDA nanosystem, we achieved a sensitive, selective, and high-throughput bioassay for glucose in human serum and whole blood, thereby revealing the great potential of the UCNPs-PDA nanosystem for the accurate detection of blood glucose or other H2O2-generated biomolecules in clinical bioassays.
Heller, A.; Feldman, B. Electrochemical glucose sensors and their applications in diabetes management. Chem. Rev. 2008, 108, 2482-2505.
Harris, M. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979, 28, 1039-1057.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014, 37, S81-S90.
Alberti, K. G. M. M.; Zimmet, P. Z.; Consultation, W. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet. Med. 1998, 15, 539-553.
Xiong, Y. M.; Zhang, Y. Y.; Rong, P. F.; Yang, J.; Wang, W.; Liu, D. B. A high-throughput colorimetric assay for glucose detection based on glucose oxidase-catalyzed enlargement of gold nanoparticles. Nanoscale 2015, 7, 15584-15588.
Clarke, S. E.; Foster, J. R. A history of blood glucose meters and their role in self-monitoring of diabetes mellitus. Br. J. Biomed. Sci. 2012, 69, 83-93.
Trajanoski, Z.; Brunner, G. A.; Gfrerer, R. J.; Wach, P.; Pieber, T. R. Accuracy of home blood glucose meters during hypoglycemia. Diabetes Care 1996, 19, 1412-1415.
Liu, Q. Y.; Yang, Y. T.; Li, H.; Zhu, R. R.; Shao, Q.; Yang, S. G.; Xu, J. J. NiO nanoparticles modified with 5, 10, 15, 20-tetrakis(4-carboxylpheyl)-porphyrin: Promising peroxidase mimetics for H2O2 and glucose detection. Biosens. Bioelectron. 2015, 64, 147-153.
Zhang, J. X.; Tu, L. P.; Zhao, S.; Liu, G. H.; Wang, Y. Y.; Wang, Y.; Yue, Z. Fluorescent gold nanoclusters based photoelectrochemical sensors for detection of H2O2 and glucose. Biosens. Bioelectron. 2015, 67, 296-302.
Lu, L. F.; Li, Y. Y.; Zhang, M.; Shi, G. Y. Visual fluorescence detection of H2O2 and glucose based on "molecular beacon"-hosted Hoechst dyes. Analyst 2015, 140, 3642-3647.
Liu, B. W.; Sun, Z. Y.; Huang, P. J. J.; Liu, J. W. Hydrogen peroxide displacing DNA from nanoceria: Mechanism and detection of glucose in serum. J. Am. Chem. Soc. 2015, 137, 1290-1295.
Wang, D.; Wang, R. H.; Liu, L. J.; Qu, Y.; Wang, G. F.; Li, Y. D. Down-shifting luminescence of water soluble NaYF4: Eu3+@Ag core-shell nanocrystals for fluorescence turn-on detection of glucose. Sci. China Mater. 2017, 60, 68-74.
Medintz, I. L.; Uyeda, H. T.; Goldman, E. R.; Mattoussi, H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 2005, 4, 435-446.
Resch-Genger, U.; Grabolle, M.; Cavaliere-Jaricot, S.; Nitschke, R.; Nann, T. Quantum dots versus organic dyes as fluorescent labels. Nat. Methods 2008, 5, 763-775.
Zheng, W.; Huang, P.; Tu, D. T.; Ma, E.; Zhu, H. M.; Chen, X. Y. Lanthanide-doped upconversion nano-bioprobes: Electronic structures, optical properties, and biodetection. Chem. Soc. Rev. 2015, 44, 1379-1415.
Wang, J. W.; Tanner, P. A. Upconversion for white light generation by a single compound. J. Am. Chem. Soc. 2010, 132, 947-949.
Zhou, B.; Shi, B. Y.; Jin, D. Y.; Liu, X. G. Controlling upconversion nanocrystals for emerging applications. Nat. Nanotechnol. 2015, 10, 924-936.
Su, Q. Q.; Feng, W.; Yang, D. P.; Li, F. Y. Resonance energy transfer in upconversion nanoplatforms for selective biodetection. Acc. Chem. Res. 2017, 50, 32-40.
Tsang, M. K.; Ye, W. W.; Wang, G. J.; Li, J. M.; Yang, M.; Hao, J. H. Ultrasensitive detection of ebola virus oligonucleotide based on upconversion nanoprobe/nanoporous membrane system. ACS Nano 2016, 10, 598-605.
Liu, Y. Y.; Zhang, J. W.; Zuo, C. J.; Zhang, Z.; Ni, D. L.; Zhang, C.; Wang, J.; Zhang, H.; Yao, Z. W.; Bu, W. B. Upconversion nano-photosensitizer targeting into mitochondria for cancer apoptosis induction and cyt c fluorescence monitoring. Nano Res. 2016, 9, 3257-3266.
Xu, W.; Zhu, Y. S.; Chen, X.; Wang, J.; Tao, L.; Xu, S.; Liu, T.; Song, H. W. A novel strategy for improving upconversion luminescence of NaYF4: Yb, Er nanocrystals by coupling with hybrids of silver plasmon nanostructures and poly(methyl methacrylate) photonic crystals. Nano Res. 2013, 6, 795-807.
Huang, P.; Tu, D. T.; Zheng, W.; Zhou, S. Y.; Chen, Z.; Chen, X. Y. Inorganic lanthanide nanoprobes for background-free luminescent bioassays. Sci. China Mater. 2015, 58, 156-177.
Luo, W. Q.; Liu, Y. S.; Chen, X. Y. Lanthanide-doped semiconductor nanocrystals: Electronic structures and optical properties. Sci. China Mater. 2015, 58, 819-850.
Lu, S.; Tu, D. T.; Li, X. J.; Li, R. F.; Chen, X. Y. A facile "ship-in-a-bottle" approach to construct nanorattles based on upconverting lanthanide-doped fluorides. Nano Res. 2016, 9, 187-197.
Liu, J. L.; Lu, L. L.; Li, A. Q.; Tang, J.; Wang, S. G.; Xu, S. Y.; Wang, L. Y. Simultaneous detection of hydrogen peroxide and glucose in human serum with upconversion luminescence. Biosens. Bioelectron. 2015, 68, 204-209.
Yuan, J.; Cen, Y.; Kong, X. J.; Wu, S.; Liu, C. L.; Yu, R. Q.; Chu, X. MnO2-nanosheet-modified upconversion nanosystem for sensitive turn-on fluorescence detection of H2O2 and glucose in blood. ACS Appl. Mater. Interfaces 2015, 7, 10548-10555.
Wu, S.; Kong, X. J.; Cen, Y.; Yuan, J.; Yu, R. Q.; Chu, X. Fabrication of a LRET-based upconverting hybrid nanocomposite for turn-on sensing of H2O2 and glucose. Nanoscale 2016, 8, 8939-8946.
Zhang, C. L.; Yuan, Y. X.; Zhang, S. M.; Wang, Y. H.; Liu, Z. H. Biosensing platform based on fluorescence resonance energy transfer from upconverting nanocrystals to graphene oxide. Angew. Chem. , Int. Ed. 2011, 50, 6851-6854.
Lee, H.; Dellatore, S. M.; Miller, W. M.; Messersmith, P. B. Mussel-inspired surface chemistry for multifunctional coatings. Science 2007, 318, 426-430.
Ku, S. H.; Park, C. B. Human endothelial cell growth on mussel-inspired nanofiber scaffold for vascular tissue engineering. Biomaterials 2010, 31, 9431-9437.
Kang, S. M.; You, I.; Cho, W. K.; Shon, H. K.; Lee, T. G.; Choi, I. S.; Karp, J. M.; Lee, H. One-step modification of superhydrophobic surfaces by a mussel-inspired polymer coating. Angew. Chem. , Int. Ed. 2010, 49, 9401-9404.
Liu, Y. L.; Ai, K. L.; Lu, L. H. Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 2014, 114, 5057-5115.
Swan, G. A. Chemical structure of melanins. Ann. N. Y. Acad. Sci. 1963, 100, 1005-1019.
Qiang, W. B.; Li, W.; Li, X. Q.; Chen, X.; Xu, D. K. Bioinspired polydopamine nanospheres: A superquencher for fluorescence sensing of biomolecules. Chem. Sci. 2014, 5, 3018-3024.
Tu, D. T.; Liu, Y. S.; Zhu, H. M.; Li, R. F.; Liu, L. Q.; Chen, X. Y. Breakdown of crystallographic site symmetry in lanthanide-doped NaYF4 crystals. Angew. Chem. , Int. Ed. 2013, 52, 1128-1133.
Bogdan, N.; Vetrone, F.; Ozin, G. A.; Capobianco, J. A. Synthesis of ligand-free colloidally stable water dispersible brightly luminescent lanthanide-doped upconverting nanoparticles. Nano Lett. 2011, 11, 835-840.
Krämer, K. W.; Biner, D.; Frei, G.; Güdel, H. U.; Hehlen, M. P.; Lüthi, S. R. Hexagonal sodium yttrium fluoride based green and blue emitting upconversion phosphors. Chem. Mater. 2004, 16, 1244-1251.
Huang, P.; Zheng, W.; Zhou, S. Y.; Tu, D. T.; Chen, Z.; Zhu, H. M.; Li, R. F.; Ma, E.; Huang, M. D.; Chen, X. Y. Lanthanide-doped LiLuF4 upconversion nanoprobes for the detection of disease biomarkers. Angew. Chem. , Int. Ed. 2014, 53, 1252-1257.
Wong, C. M.; Wong, K. H.; Chen, X. D. Glucose oxidase: Natural occurrence, function, properties and industrial applications. Appl. Microbiol. Biotechnol. 2008, 78, 927-938.
Shan, C. S.; Yang, H. F.; Song, J. F.; Han, D. X.; Ivaska, A.; Niu, L. Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene. Anal. Chem. 2009, 81, 2378-2382.
Zheng W.; Zhou S. Y.; Xu J.; Liu Y. S.; Huang P.; Liu Y.; Chen X. Y. Ultrasensitive luminescent in vitro detection for tumor markers based on inorganic lanthanide nano-bioprobes. Adv. Sci. 2016, 3, 1600197.
Wang, M.; Chen, Z.; Zheng, W.; Zhu, H. M.; Lu, S.; Ma, E.; Tu, D. T.; Zhou, S. Y.; Huang, M. D.; Chen, X. Y. Lanthanide-doped upconversion nanoparticles electrostatically coupled with photosensitizers for near-infrared-triggered photodynamic therapy. Nanoscale 2014, 6, 8274-8282.
Chen, H. Y.; Fang, A. J.; He, L.; Zhang, Y. Y.; Yao, S. Z. Sensitive fluorescent detection of H2O2 and glucose in human serum based on inner filter effect of squaric acid-iron(Ⅲ) on the fluorescence of upconversion nanoparticle. Talanta 2017, 164, 580-587.
Xiao, Y.; Zeng, L. Y.; Xia, T.; Wu, Z. J.; Liu, Z. H. Construction of an upconversion nanoprobe with few-atom silver nanoclusters as the energy acceptor. Angew. Chem. , Int. Ed. 2015, 54, 5323-5327.
Li, Z.; Liang, T.; Lv, S. W.; Zhuang, Q. G.; Liu, Z. H. A rationally designed upconversion nanoprobe for in vivo detection of hydroxyl radical. J. Am. Chem. Soc. 2015, 137, 11179-11185.
Achatz, D. E.; Meier, R. J.; Fischer, L. H.; Wolfbeis, O. S. Luminescent sensing of oxygen using a quenchable probe and upconverting nanoparticles. Angew. Chem. , Int. Ed. 2011, 50, 260-263.
Gorris, H. H.; Wolfbeis, O. S. Photon-upconverting nanoparticles for optical encoding and multiplexing of cells, biomolecules, and microspheres. Angew. Chem. , Int. Ed. 2013, 52, 3584-3600.
Lin, J. H.; Yu, C. J.; Yang, Y. C.; Tseng, W. L. Formation of fluorescent polydopamine dots from hydroxyl radical-induced degradation of polydopamine nanoparticles. Phys. Chem. Chem. Phys. 2015, 17, 15124-15130.
Shah, V. P.; Midha, K. K.; Findlay, J. W. A.; Hill, H. M.; Hulse, J. D.; McGilveray, I. J.; McKay, G.; Miller, K. J.; Patnaik, R. N.; Powell, M. L. et al. Bioanalytical method validation-a revisit with a decade of progress. Pharm. Res. 2000, 17, 1551-1557.
Wang, M.; Li, M.; Yang, M. Y.; Zhang, X. M.; Yu, A. Y.; Zhu, Y.; Qiu, P. H.; Mao, C. B. NIR-induced highly sensitive detection of latent fingermarks by NaYF4: Yb, Er upconversion nanoparticles in a dry powder state. Nano Res. 2015, 8, 1800-1810.
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