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Photodynamic therapy (PDT), as a noninvasive therapeutic method, has been actively explored recently for cancer treatment. However, owing to the weak absorption in the optically transparent windows of biological tissues, most commercial photosensitizers (PSs) exhibit low singlet oxygen (1O2) quantum yields when excited by light within this window. Finding the best way to boost 1O2 production for clinical applications using light sources within this window is, thus, a great challenge. Herein, we tackle this problem using plasmon resonance energy transfer (PRET) from plasmonic nanoparticles (NPs) to PSs and demonstrate that the formation of plasmon quenching dips is an effective way to enhance 1O2 generation. The combination of the photosensitizer chlorin e6 (Ce6) and gold nanorods (AuNR) was employed as a model system. We observed a clear quenching dip in the longitudinal surface plasmon resonance (LSPR) band of the AuNRs when the LSPR band overlaps with the Q band of Ce6 and the spacing between Ce6 and the rods is within the acting distance of PRET. Upon irradiation with 660 nm continuous-wave laser light, we obtained a seven-fold enhancement in the 1O2 signal intensity compared with that of a non-PRET sample, as determined using the 1O2 electron spin resonance probe 2, 2, 6, 6-tetramethyl-4-piperidine (TEMP). Furthermore, we demonstrated that the PRET effect is more efficient in enhancing 1O2 yield than the often-employed local field enhancement effect. The effectiveness of PRET is further extended to the in vitro level. Considering the flexibility in manipulating the localized SPR properties of plasmonic nanoparticles/nanostructures, our findings suggest that PRET-based strategies may be a general way to overcome the deficiency of most commercial organic PSs in biological optically transparent windows and promote their applications in clinical tumor treatments.
DeRosa, M. C.; Crutchley, R. J. Photosensitized singlet oxygen and its applications. Chem. Rev. 2002, 233–234, 351–371.
Dolmans, D. E. J. G. J.; Fukumura, D.; Jain, R. K. Photodynamic therapy for cancer. Nat. Rev. Cancer 2003, 3, 380–387.
Alberti, M. N.; Orfanopoulos, M. Stereoelectronic and solvent effects on the allylic oxyfunctionalization of alkenes with singlet oxygen. Tetrahedron 2006, 62, 10660–10675.
Ogilby, P. R. Singlet oxygen: There is indeed something new under the sun. Chem. Soc. Rev. 2010, 39, 3181–3209.
Schweitzer, C.; Schmidt, R. Physical mechanisms of generation and deactivation of singlet oxygen. Chem. Rev. 2003, 103, 1685–1758.
Kuimova, M. K.; Botchway, S. W.; Parker, A. W.; Balaz, M.; Collins, H. A.; Anderson, H. L.; Suhling, K.; Ogilby, P. R. Imaging intracellular viscosity of a single cell during photoinduced cell death. Nat. Chem. 2009, 1, 69–73.
Castano, A. P.; Mroz, P.; Hamblin, M. R. Photodynamic therapy and anti-tumour immunity. Nat. Rev. Cancer 2006, 6, 535–545.
Allison, R. R.; Sibata, C. H. Oncologic photodynamic therapy photosensitizers: A clinical review. Photodiagn. Photodyn. Ther. 2010, 7, 61–75.
Celli, J. P.; Spring, B. Q.; Rizvi, I.; Evans, C. L.; Samkoe, K. S.; Verma, S.; Pogue, B. W.; Hasan, T. Imaging and photodynamic therapy: Mechanisms, monitoring, and optimization. Chem. Rev. 2010, 110, 2795–2838.
Agostinis, P.; Berg, K.; Cengel, K. A.; Foster, T. H.; Girotti, A. W.; Gollnick, S. O.; Hahn, S. M.; Hamblin, M. R.; Juzeniene, A.; Kessel, D. et al. Photodynamic therapy of cancer: An update. CA-Cancer J. Clin. 2011, 61, 250–281.
Allison, R. R.; Downie, G. H.; Cuenca, R.; Hu, X. H.; Childs, C. J.; Sibata, C. H. Photosensitizers in clinical PDT. Photodiagn. Photodyn. Ther. 2004, 1, 27–42.
Lucky, S. S.; Soo, K. C.; Zhang, Y. Nanoparticles in photodynamic therapy. Chem. Rev. 2015, 115, 1990–2042.
Paszko, E.; Ehrhardt, C.; Senge, M.O.; Kelleher, D. P.; Reynolds, J. V. Nanodrug applications in photodynamic therapy. Photodiagn. Photodyn. Ther. 2011, 8, 14–29.
Bechet, D.; Couleaud, P.; Frochot, C.; Viriot, M. L.; Guillemin, F.; Barberi-Heyob, M. Nanoparticles as vehicles for delivery of photodynamic therapy agents. Trends Biotechnol. 2008, 26, 612–621.
Rana, S.; Bajaj, A.; Mout, R.; Rotello, V. M. Monolayer coated gold nanoparticles for delivery applications. Adv. Drug Delivery Rev. 2012, 64, 200–216.
Gao, L.; Fei, J. B.; Zhao, J.; Li, H.; Cui, Y.; Li, J. B. Hypocrellin-loaded gold nanocages with high two-photon efficiency for photothermal/photodynamic cancer therapy in vitro. ACS Nano. 2012, 6, 8030–8040.
Wang, S. J.; Huang, P.; Nie, L. M.; Xing, R. J.; Liu, D. B.; Wang, Z.; Lin, J.; Chen, S. H.; Niu, G.; Lu, G. M. et al. Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars. Adv. Mater. 2013, 25, 3055–3061.
Lin, J.; Wang, S. J.; Huang, P.; Wang, Z.; Chen, S. H.; Niu, G.; Li, W. W.; He, J.; Cui, D. X.; Lu, G. M. et al. Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy. ACS Nano 2013, 7, 5320–5329.
Kreyling, W. G.; Abdelmonem, A. M.; Ali, Z.; Alves, F.; Geiser, M.; Haberl, N.; Hartmann, R.; Hirn, S.; de Aberasturi, D. J.; Kantner, K. et al. In vivo integrity of polymer-coated gold nanoparticles. Nat. Nanotechnol. 2015, 10, 619–623.
Kuo, W. S.; Chang, C. N.; Chang, Y. T.; Yang, M. H.; Chien, Y. H.; Chen, S. J.; Yeh, C. S. Gold Nanorods in photodynamic therapy, as hyperthermia agents, and in near-infrared optical imaging. Angew. Chem., Int. Ed. 2010, 49, 2711–2715.
Jang, B.; Park, J. Y.; Tung, C. H.; Kim, I. H.; Choi, Y. Gold nanorod-photosensitizer complex for near-infrared fluorescence imaging and photodynamic/photothermal therapy in vivo. ACS Nano 2011, 5, 1086–1094.
Zhang, Z. J.; Wang, J.; Nie, X.; Wen, T.; Ji, Y. L.; Wu, X. C.; Zhao, Y. L.; Chen, C. Y. Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J. Am. Chem. Soc. 2014, 136, 7317–7326.
Wang, J.; You, M. X.; Zhu, G. Z.; Shukoor, M. I.; Chen, Z.; Zhao, Z. L.; Altman, M. B.; Yuan, Q.; Zhu, Z.; Chen, Y. et al. Photosensitizer–gold nanorod composite for targeted multimodal therapy. Small 2013, 9, 3678–3684.
Wang, N. N.; Zhao, Z. L.; Lv, Y. F.; Fan, H. H.; Bai, H. R.; Meng, H. M.; Long, Y. Q.; Fu, T.; Zhang, X. B.; Tan, W. H. Gold nanorod–photosensitizer conjugate with extracellular ph-driven tumor targeting ability for photothermal/ photodynamic therapy. Nano Res. 2014, 7, 1291–1301.
Xu, Y. K.; He, R. Y.; Lin, D. D.; Ji, M. B.; Chen, J. Y. Laser beam controlled drug release from Ce6–gold nanorod composites in living cells: A FLIM study. Nanoscale 2015, 7, 2433–2441.
Li, Y. Y.; Wen, T.; Zhao, R. F.; Liu, X. X.; Ji, T. J.; Wang, H.; Shi, X. W.; Shi, J.; Wei, J. Y.; Zhao, Y. L. et al. Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy. ACS Nano 2014, 8, 11529–11542.
Lu, K. D.; He, C. B.; Lin, W. B. Nanoscale metal?organic framework for highly effective photodynamic therapy of resistant head and neck cancer. J. Am. Chem. Soc. 2014, 136, 16712–16715.
Ding, X. S.; Han, B. H. Metallophthalocyanine-Based conjugated microporous polymers as highly efficient photosensitizers for singlet oxygen generation. Angew. Chem., Int. Ed. 2015, 54, 6536–6539.
Lu, K. D.; He, C. B.; Lin, W. B. A chlorin-based nanoscale metal?organic framework for photodynamic therapy of colon cancers. J. Am. Chem. Soc. 2015, 137, 7600–7603.
Park, J.; Jiang, Q.; Feng, D. W.; Mao, L. Q.; Zhou, H. C. Size-controlled synthesis of porphyrinic metal?organic framework and functionalization for targeted photodynamic therapy. J. Am. Chem. Soc. 2016, 138, 3518–3525.
Ni, W. H.; Ambj?rnsson, T.; Apell, S. P.; Chen, H. J.; Wang, J. F. Observing plasmonic–molecular resonance coupling on single gold nanorods. Nano Lett. 2010, 10, 77–84.
Chen, H. J.; Ming, T.; Zhao, L.; Wang, F.; Sun, L. D.; Wang, J. F.; Yan, C. H. Plasmon–molecule interactions. Nanotoday 2010, 5, 494–505.
DeLacy, B. G.; Miller, O. D.; Hsu, C. W.; Zander, Z.; Lacey, S.; Yagloski, R.; Fountain, A, W.; Valdes, E.; Anquillare, E.; Solja?i?, M. et al. Coherent plasmon–exciton coupling in silver platelet-J-aggregate nanocomposites. Nano Lett. 2015, 15, 2588–2593.
Chen, H. J.; Shao, L.; Woo, K. C.; Wang, J. F.; Lin, H. Q. Plasmonic?molecular resonance coupling: Plasmonic splitting versus energy transfer. J. Phys. Chem. C 2012, 116, 14088–14095.
Choi, Y.; Kang, T.; Lee, L. P. Plasmon resonance energy transfer (PRET)-based molecular imaging of cytochrome c in living cells. Nano Lett. 2009, 9, 85–90.
Qu, W. G.; Deng, B.; Zhong, S. L.; Shi, H. Y.; Wang, S. S.; Xu, A. W. Plasmonic resonance energy transfer-based nanospectroscopy for sensitive and selective detection of 2, 4, 6-trinitrotoluene (TNT). Chem. Commun. 2011, 47, 1237–1239.
Li, J. T.; Cushing, S. K.; Meng, F. K.; Senty, T. R.; Bristow, A. D.; Wu, N. Q. Plasmon-induced resonance energy transfer for solar energy conversion. Nat. Photonics 2015, 9, 601–607.
Nan, F.; Ding, S. J.; Ma, L.; Cheng, Z. Q.; Zhong, Y. T.; Zhang, Y. F.; Qiu, Y. H.; Li, X. G.; Zhou, L.; Wang, Q. Q. Plasmon resonance energy transfer and plexcitonic solar cell. Nanoscale 2016, 8, 15071–15078.
Cao, Y.; Xie, T.; Qian, R. C.; Long, Y. T. Plasmon resonance energy transfer: Coupling between chromophore molecules and metallic nanoparticles. Small 2016, 13, 1601955.
Hu, Z. J.; Hou, S.; Ji, Y. L.; Wen, T.; Liu, W. Q.; Zhang, H.; Shi, X. W.; Yan, J.; Wu, X. C. Fast characterization of gold nanorods ensemble by correlating its structure with optical extinction spectral features. AIP Adv. 2014, 4, 117137.
Park, K.; Drummy, L. F.; Vaia, R. A. Ag Shell morphology on Au nanorod core: role of Ag precursor complex. J. Mater. Chem. 2011, 21, 15608–15618.
Jadhao, M.; Ahirkar, P.; Kumar, H.; Joshi, R.; Meitei, O. R.; Ghosh, S. K. Surfactant induced aggregation-disaggregation of photodynamic active chlorin e6 and its relevant interaction with DNA alkylating Quinone in a biomimic micellar microenvironment. RSC Adv. 2015, 5, 81449–81460.
Sen, T.; Patra, A. Resonance energy transfer from Rhodamine 6G to gold nanoparticles by steady-state and time-resolved spectroscopy. J. Phys. Chem. C 2008, 112, 3216–3222.
Singh, M. P.; Strouse, G. F. Involvement of the LSPR spectral overlap for energy transfer between a dye and Au nanoparticle. J. Am. Chem. Soc. 2010, 132, 9383–9391.
Pacioni, N. L.; González-Béjar, M; Alarcón, E.; McGilvray, K. L.; Scaiano, J. C. Surface Plasmons control the dynamics of excited triplet states in the presence of gold nanoparticles. J. Am. Chem. Soc. 2010, 132, 6298–6299.
Gao, M. X.; Zou, H. Y.; Gao, P. F.; Liu, Y.; Li, N.; Li, Y. F.; Huang, C. Z. Insight into a reversible energy transfer system. Nanoscale 2016, 8, 16236–16242.
Planas, O.; Macia, N.; Agut, M.; Nonell, S.; Heyne, B. Distance-dependent plasmon-enhanced singlet oxygen production and emission for bacterial inactivation. J. Am. Chem. Soc. 2016, 138, 2762–2768.
Liu, G. L.; Long, Y. T.; Choi, Y.; Kang, T.; Lee, L. P. Quantized Plasmon quenching dips nanospectroscopy via Plasmon resonance energy transfer. Nat. Methods 2007, 4, 1015–1017.
Wen, T.; Zhang, H.; Chong, Y.; Wamer, W. G.; Yin, J. J.; Wu, X. C. Probing hydroxyl radical generation from H2O2 upon Plasmon excitation of gold nanorods using electron spin resonance: Molecular oxygen-mediated activation. Nano Res. 2016, 9, 1663–1673.
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