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Two-dimensional transition metal dichalcogenides (2D TMDs) possess a tunable excitonic light emission that is sensitive to external conditions such as electric field, strain, and chemical doping. In this work, we reveal the interactions between DNA nucleobases, i.e., adenine (A), guanine (G), cytosine (C), and thymine (T) and monolayer WS2 by investigating the changes in the photoluminescence (PL) emissions of the monolayer WS2 after coating with nucleobase solutions. We found that adenine and guanine exert a clear effect on the PL profile of the monolayer WS2 and cause different PL evolution trends. In contrast, cytosine and thymine have little effect on the PL behavior. To obtain information on the interactions between the DNA bases and WS2, a series of measurements were conducted on adenine-coated WS2 monolayers, as a demonstration. The p-type doping of the WS2 monolayers on the introduction of adenine is clearly shown by both the evolution of the PL spectra and the electrical transport response. Our findings open the door for the development of label-free optical sensing approaches in which the detection signals arise from the tunable excitonic emission of the TMD itself rather than the fluorescence signals of label molecules. This dopant-selective optical response to the DNA nucleobases fills the gaps in previously reported optical biosensing methods and indicates a potential new strategy for DNA sequencing.
Berghäuser, G.; Malic, E. Analytical approach to excitonic properties of MoS2. Phys. Rev. B 2014, 89, 125309.
Ramasubramaniam, A. Large excitonic effects in monolayers of molybdenum and tungsten dichalcogenides. Phys. Rev. B 2012, 86, 115409.
Wang, Q. H.; Kalantar-Zadeh, K.; Kis, A.; Coleman, J. N.; Strano, M. S. Electronics and optoelectronics of two-dimensional transition metal dichalcogenides. Nat. Nanotechnol. 2012, 7, 699-712.
Mak, K. F.; Lee, C.; Hone, J.; Shan, J.; Heinz, T. F. Atomically thin MoS2: A new direct-gap semiconductor. Phys. Rev. Lett. 2010, 105, 136805.
Huard, V.; Cox, R. T.; Saminadayar, K.; Arnoult, A.; Tatarenko, S. Bound states in optical absorption of semiconductor quantum wells containing a two-dimensional electron gas. Phys. Rev. Lett. 2000, 84, 187-190.
Mak, K. F.; He, K. L.; Lee, C. G.; Lee, G. H.; Hone, J.; Heinz, T. F.; Shan, J. Tightly bound trions in monolayer MoS2. Nat. Mater. 2013, 12, 207-211.
Shang, J. Z.; Shen, X. N.; Cong, C. X.; Peimyoo, N.; Cao, B. C.; Eginligil, M.; Yu, T. Observation of excitonic fine structure in a 2D transition-metal dichalcogenide semiconductor. ACS Nano 2015, 9, 647-655.
Peimyoo, N.; Yang, W. H.; Shang, J. Z.; Shen, X. N.; Wang, Y. L.; Yu, T. Chemically driven tunable light emission of charged and neutral excitons in monolayer WS2. ACS Nano 2014, 8, 11320-11329.
Nan, H. Y.; Wang, Z. L.; Wang, W. H.; Liang, Z.; Lu, Y.; Chen, Q.; He, D. W.; Tan, P. H.; Miao, F.; Wang, X. R. et al. Strong photoluminescence enhancement of MoS2 through defect engineering and oxygen bonding. ACS Nano 2014, 8, 5738-5745.
Wang, Y. L.; Cong, C. X.; Yang, W. H.; Shang, J. Z.; Peimyoo, N.; Chen, Y.; Kang, J. Y.; Wang, J. P.; Huang, W.; Yu, T. Strain-induced direct-indirect bandgap transition and phonon modulation in monolayer WS2. Nano Res. 2015, 8, 2562-2572.
Kim, E.; Ko, C.; Kim, K.; Chen, Y. B.; Suh, J.; Ryu, S. -G.; Wu, K. D.; Meng, X. Q.; Suslu, A.; Tongay, S. et al. Site selective doping of ultrathin metal dichalcogenides by laser-assisted reaction. Adv. Mater. 2016, 28, 341-346.
Amani, M.; Lien, D. -H.; Kiriya, D.; Xiao, J.; Azcatl, A.; Noh, J.; Madhvapathy, S. R.; Addou, R.; KC, S.; Dubey, M. et al. Near-unity photoluminescence quantum yield in MoS2. Science 2015, 350, 1065-1068.
Han, H. V.; Lu, A. Y.; Lu, L. S.; Huang, J. K.; Li, H. N.; Hsu, C. L.; Lin, Y. C.; Chiu, M. H.; Suenaga, K.; Chu, C. W. et al. Photoluminescence enhancement and structure repairing of monolayer MoSe2 by hydrohalic acid treatment. ACS Nano 2016, 10, 1454-1461.
Tongay, S.; Zhou, J.; Ataca, C.; Liu, J.; Kang, J. S.; Matthews, T. S.; You, L.; Li, J. B.; Grossman, J. C.; Wu, J. Q. Broad-range modulation of light emission in two-dimensional semiconductors by molecular physisorption gating. Nano Lett. 2013, 13, 2831-2836.
Mouri, S.; Miyauchi, Y.; Matsuda, K. Tunable photoluminescence of monolayer MoS2 via chemical doping. Nano Lett. 2013, 13, 5944-5948.
Vovusha, H.; Sanyal, B. Adsorption of nucleobases on 2D transition-metal dichalcogenides and graphene sheet: A first principles density functional theory study. RSC Adv. 2015, 5, 67427-67434.
Farimani, A. B.; Min, K.; Aluru, N. R. DNA base detection using a single-layer MoS2. ACS Nano 2014, 8, 7914-7922.
Sharma, M.; Kumar, A.; Ahluwalia, P. K. Optical fingerprints and electron transport properties of DNA bases adsorbed on monolayer MoS2. RSC Adv. 2016, 6, 60223-60230.
Zhang, Y.; Zheng, B.; Zhu, C. F.; Zhang, X.; Tan, C. L.; Li, H.; Chen, B.; Yang, J.; Chen, J. Z.; Huang, Y. et al. Single-layer transition metal dichalcogenide nanosheet-based nanosensors for rapid, sensitive, and multiplexed detection of DNA. Adv. Mater. 2015, 27, 935-939.
Chen, J.; Gao, C. J.; Mallik, A. K.; Qiu, H. D. A WS2 nanosheet-based nanosensor for the ultrasensitive detection of small molecule-protein interaction via terminal protection of small molecule-linked DNA and Nt. BstNBI-assisted recycling amplification. J. Mater. Chem. B 2016, 4, 5161- 5166.
Zhao, J. J.; Jin, X.; Vdovenko, M.; Zhang, L. L.; Sakharov, I. Y.; Zhao, S. L. A WS2 nanosheet based chemiluminescence resonance energy transfer platform for sensing biomolecules. Chem. Commun. 2015, 51, 11092-11095.
Macwan, I.; Khan, M. D. H.; Aphale, A.; Singh, S.; Liu, J.; Hingorani, M.; Patra, P. Interactions between avidin and graphene for development of a biosensing platform. Biosens. Bioelectron. 2017, 89, 326-333.
Loan, P. T. K.; Zhang, W. J.; Lin, C. T.; Wei, K. H.; Li, L. J.; Chen, C. H. Graphene/MoS2 heterostructures for ultrasensitive detection of DNA hybridisation. Adv. Mater. 2014, 26, 4838-4844.
Ananthanarayanan, A.; Wang, X. W.; Routh, P.; Sana, B.; Lim, S.; Kim, D. H.; Lim, K. H.; Li, J.; Chen, P. Facile synthesis of graphene quantum dots from 3D graphene and their application for Fe3+ sensing. Adv. Funct. Mater. 2014, 24, 3021-3026.
Ananthanarayanan, A.; Wang, Y.; Routh, P.; Sk, M. A.; Than, A.; Lin, M.; Zhang, J.; Chen, J.; Sun, H. D.; Chen, P. Nitrogen and phosphorus co-doped graphene quantum dots: Synthesis from adenosine triphosphate, optical properties, and cellular imaging. Nanoscale 2015, 7, 8159-8165.
Zeng, S. W.; Sreekanth, K. V.; Shang, J. Z.; Yu, T.; Chen, C. K.; Yin, F.; Baillargeat, D.; Coquet, P.; Ho, H. P.; Kabashin, A. V. et al. Graphene-gold metasurface architectures for ultrasensitive plasmonic biosensing. Adv. Mater. 2015, 27, 6163-6169.
Li, Z.; Chen, Y.; Li, X.; Kamins, T.; Nauka, K.; Williams, R. S. Sequence-specific label-free DNA sensors based on silicon nanowires. Nano Lett. 2004, 4, 245-247.
Star, A.; Tu, E.; Niemann, J.; Gabriel, J. -C. P.; Joiner, C. S.; Valcke, C. Label-free detection of DNA hybridization using carbon nanotube network field-effect transistors. Proc. Natl. Acad. Sci. USA 2006, 103, 921-926.
Zhu, C. F.; Zeng, Z. Y.; Li, H.; Li, F.; Fan, C. H.; Zhang, H. Single-layer MoS2-based nanoprobes for homogeneous detection of biomolecules. J. Am. Chem. Soc. 2013, 135, 5998-6001.
Lee, J.; Dak, P.; Lee, Y.; Park, H.; Choi, W.; Alam, M. A.; Kim, S. Two-dimensional layered MoS2 biosensors enable highly sensitive detection of biomolecules. Sci. Rep. 2014, 4, 7352.
Beaudet, A. L.; Belmont, J. W. Array-based DNA diagnostics: Let the revolution begin. Annu. Rev. Med. 2008, 59, 113-129.
Peimyoo, N.; Shang, J. Z.; Cong, C. X.; Shen, X. N.; Wu, X. Y.; Yeow, E. K. L.; Yu, T. Nonblinking, intense two- dimensional light emitter: Monolayer WS2 triangles. ACS Nano 2013, 7, 10985-10994.
Cong, C. X.; Shang, J. Z.; Wu, X.; Cao, B. C.; Peimyoo, N.; Qiu, C. Y.; Sun, L. T.; Yu, T. Synthesis and optical properties of large-area single-crystalline 2D semiconductor WS2 monolayer from chemical vapor deposition. Adv. Opt. Mater. 2014, 2, 131-136.
Berkdemir, A.; Gutiérrez, H. R.; Botello-Méndez, A. R.; Perea-López, N.; Elías, A. L.; Chia, C. -I.; Wang, B.; Crespi, V. H.; López-Urías, F.; Charlier, J. -C. et al. Identification of individual and few layers of WS2 using Raman spectroscopy. Sci. Rep. 2013, 3, 1755.
Zeng, H. L.; Liu, G. -B.; Dai, J. F.; Yan, Y. J.; Zhu, B. R.; He, R. C.; Xie, L.; Xu, S. J.; Chen, X. H.; Yao, W. et al. Optical signature of symmetry variations and spin-valley coupling in atomically thin tungsten dichalcogenides. Sci. Rep. 2013, 3, 1608.
Gutiérrez, H. R.; Perea-López, N.; Elías, A. L.; Berkdemir, A.; Wang, B.; Lv, R. T.; López-Urías, F.; Crespi, V. H.; Terrones, H.; Terrones, M. Extraordinary room-temperature photoluminescence in triangular WS2 monolayers. Nano Lett. 2013, 13, 3447-3454.
Ross, J. S.; Wu, S. F.; Yu, H. Y.; Ghimire, N. J.; Jones, A. M.; Aivazian, G.; Yan, J. Q.; Mandrus, D. G.; Xiao, D.; Yao, W. et al. Electrical control of neutral and charged excitons in a monolayer semiconductor. Nat. Commun. 2013, 4, 1474.
Ryder, C. R.; Wood, J. D.; Wells, S. A.; Hersam, M. C. Chemically tailoring semiconducting two-dimensional transition metal dichalcogenides and black phosphorus. ACS Nano 2016, 10, 3900-3917.
Cho, B.; Yoon, J.; Lim, S. K.; Kim, A. R.; Kim, D. -H.; Park, S. -G.; Kwon, J. -D.; Lee, Y. -J.; Lee, K. -H.; Lee, B. H. et al. Chemical sensing of 2D graphene/MoS2 heterostructure device. ACS Appl. Mater. Interfaces 2015, 7, 16775-16780.
Liang, L. J.; Hu, W.; Xue, Z. Y.; Shen, J. -W. Theoretical study on the interaction of nucleotides on two-dimensional atomically thin graphene and molybdenum disulfide. FlatChem 2017, 2, 8-14.
Dontschuk, N.; Stacey, A.; Tadich, A.; Rietwyk, K. J.; Schenk, A.; Edmonds, M. T.; Shimoni, O.; Pakes, C. I.; Prawer, S.; Cervenka, J. A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases. Nat. Commun. 2015, 6, 6563.
Zhou, W.; Zou, X. L.; Najmaei, S.; Liu, Z.; Shi, Y. M.; Kong, J.; Lou, J.; Ajayan, P. M.; Yakobson, B. I.; Idrobo, J. -C. Intrinsic structural defects in monolayer molybdenum disulfide. Nano Lett. 2013, 13, 2615-2622.
Lee, J. -H.; Choi, Y. -K.; Kim, H. -J.; Scheicher, R. H.; Cho, J. -H. Physisorption of DNA nucleobases on h-BN and graphene: vdW-corrected DFT calculations. J. Phys. Chem. C 2013, 117, 13435-13441.
Hawke, L. G. D.; Kalosakas, G.; Simserides, C. Electronic parameters for charge transfer along DNA. Eur. Phys. J. E 2010, 32, 291.
Kang, J.; Tongay, S.; Zhou, J.; Li, J. B.; Wu, J. Q. Band offsets and heterostructures of two-dimensional semiconductors. Appl. Phys. Lett. 2013, 102, 012111.
Xi, Q.; Zhou, D. -M.; Kan, Y. -Y.; Ge, J.; Wu, Z. -K.; Yu, R. -Q.; Jiang, J. -H. Highly sensitive and selective strategy for microRNA detection based on WS2 nanosheet mediated fluorescence quenching and duplex-specific nuclease signal amplification. Anal. Chem. 2014, 86, 1361-1365.
Wang, Z.; Dong, Z. G.; Gu, Y. H.; Chang, Y. -H.; Zhang, L.; Li, L. -J.; Zhao, W. J.; Eda, G.; Zhang, W. J.; Grinblat, G. et al. Giant photoluminescence enhancement in tungsten-diselenide-gold plasmonic hybrid structures. Nat. Commun. 2016, 7, 11283.
