AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Research Article
Article Link
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article

Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging

Zhenglin Li1,2,3, Zhuo Li1, Lei Chen4, Ying Hu5, Shaoshan Hu4, Zhaohua Miao6, Ye Sun2( ), Flemming Besenbacher3( ), Miao Yu1( )
State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemical Engineering and TechnologyHarbin Institute of TechnologyHarbin150001China
Condensed Matter Science and Technology InstituteHarbin Institute of TechnologyHarbin150001China
Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and AstronomyAarhus UniversityAarhus8000Denmark
Department of Neurological SurgeryThe Second Affiliated Hospital of the Harbin Medical UniversityHarbin150001China
School of Life Science and TechnologyHarbin Institute of TechnologyHarbin150001China
School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin150001China
Show Author Information

Graphical Abstract

Abstract

Theranostic nanoagents that integrate the diagnoses and therapies within a single nanomaterial are compelling in their use for highly precise and efficient antitumor treatments. Herein, polyethylene glycol (PEG)-modified cobalt sulfide nanosheets (CoS-PEG NSs) are synthesized and unitized as a powerful theranostic nanoagent for efficient photothermal conversion and multimodal imaging for the first time. We demonstrate that the obtained CoS-PEG NSs show excellent compatibility and stability in water and various physiological solutions, and can be effectively internalized by cells, but exhibit a low cytotoxicity. The CoS-PEG NSs exhibit an efficient photothermal conversion capacity, benefited from the strong near-infrared (NIR) absorption, high photothermal conversion efficiency (~33.0%), and excellent photothermal stability. Importantly, the highly effective photothermal killing effect on cancer cells after exposure to CoS-PEG NSs plus laser irradiation has been confirmed by both the standard Cell Counting Kit-8 and live-dead cell staining assays, revealing a concentration-dependent photothermal therapeutic effect. Moreover, utilizing the strong NIR absorbance together with the T2-MR contrast ability of the CoS-PEG NSs, a high-contrast triple-modal imaging, i.e., photoacoustic (PA), infrared thermal (IRT), and magnetic resonance (MR) imaging, can be achieved, suggesting a great potential for multimodal imaging to provide comprehensive cancer diagnosis. Our work introduces the first bioapplication of the CoS-PEG nanomaterial as a potential theranostic nanoplatform and may promote further rational design of CoS-based nanostructures for precise/efficient cancer diagnosis and therapy.

Keywords

cobalt sulfide nanosheetstheranostic agentphotoacoustic imagingmagnetic resonance imagingphotothermal therapy

Electronic Supplementary Material

Download File(s)
12274_2017_1865_MOESM1_ESM.pdf (1.8 MB)

References

1

Ou, G.; Li, Z. W.; Li, D. K.; Cheng, L.; Liu, Z.; Wu, H. Photothermal therapy by using titanium oxide nanoparticles. Nano Res. 2016, 9, 1236–1243.
Crossref Google Scholar
2

Siegel, R.; Naishadham, D.; Jemal, A. Cancer statistics, 2013. CA-Cancer J. Clin. 2013, 63, 11–30.
Crossref Google Scholar
3

Zhu, C. Q.; Yang, Y. H.; Luo, M.; Yang, C. X.; Wu, J. J.; Chen, L. N.; Liu, G.; Wen, T. B.; Zhu, J.; Xia, H. P. Stabilizing two classical antiaromatic frameworks: Demonstration of photoacoustic imaging and the photothermal effect in metalla-aromatics. Angew. Chem., Int. Ed. 2015, 127, 6279–6283.
Crossref Google Scholar
4

Yang, K.; Hu, L. L.; Ma, X. X.; Ye, S. Q.; Cheng, L.; Shi, X. Z.; Li, C. H.; Li, Y. G.; Liu, Z. Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles. Adv. Mater. 2012, 24, 1868–1872.
Crossref Google Scholar
5

Shao, J. D.; Xie, H. H.; Huang, H.; Li, Z. B.; Sun, Z. B.; Xu, Y. H.; Xiao, Q. L.; Yu, X. F.; Zhao, Y. T.; Zhang, H. et al. Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy. Nat. Commun. 2016, 7, 12967.
Crossref Google Scholar
6

Zhao, Z. X.; Shi, S. G.; Huang, Y. H.; Tang, S. H.; Chen, X. L. Simultaneous photodynamic and photothermal therapy using photosensitizer-functionalized Pd nanosheets by single continuous wave laser. ACS Appl. Mater. Interfaces 2014, 6, 8878–8885.
Crossref Google Scholar
7

Zhang, Z. J.; Wang, L. M.; Wang, J.; Jiang, X. M.; Li, X. H.; Hu, Z. J.; Ji, Y. L.; Wu, X. C.; Chen, C. Y. Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv. Mater. 2012, 24, 1418–1423.
Crossref Google Scholar
8

Huang, X. Q.; Tang, S. H.; Mu, X. L.; Dai, Y.; Chen, G. X.; Zhou, Z. Y.; Ruan, F. X.; Yang, Z. L.; Zheng, N. F. Freestanding palladium nanosheets with plasmonic and catalytic properties. Nat. Nanotechnol. 2011, 6, 28–32.
Crossref Google Scholar
9

Yang, K.; Zhang, S.; Zhang, G. X.; Sun, X. M.; Lee, S. T.; Liu, Z. Graphene in mice: Ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010, 10, 3318–3323.
Crossref Google Scholar
10

Cheng, L.; Liu, J. J.; Gu, X.; Gong, H.; Shi, X. Z.; Liu, T.; Wang, C.; Wang, X. Y.; Liu, G.; Xing, H. Y. et al. PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater. 2014, 26, 1886–1893.
Crossref Google Scholar
11

Chou, S. S.; Kaehr, B.; Kim, J.; Foley, B. M.; De, M.; Hopkins, P. E.; Huang, J. X.; Brinker, C. J.; Dravid, V. P. Chemically exfoliated MoS2 as near-infrared photothermal agents. Angew. Chem., Int. Ed. 2013, 125, 4254–4258.
Crossref Google Scholar
12

Li, Z. L.; Liu, J.; Hu, Y.; Howard, K. A.; Li, Z.; Fan, X. L.; Chang, M. L.; Sun, Y.; Besenbacher, F.; Chen, C. Y. et al. Multimodal imaging-guided antitumor photothermal therapy and drug delivery using bismuth selenide spherical sponge. ACS Nano 2016, 10, 9646–9658.
Crossref Google Scholar
13

Li, Z. L.; Hu, Y.; Chang, M. L.; Howard, K. A.; Fan, X. L.; Sun, Y.; Besenbacher, F.; Yu, M. Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery. Nanoscale 2016, 8, 16005–16016.
Crossref Google Scholar
14

Li, Z. L.; Hu, Y.; Howard, K. A.; Jiang, T. T.; Fan, X. L.; Miao, Z. H.; Sun, Y.; Besenbacher, F.; Yu, M. Multifunctional bismuth selenide nanocomposites for antitumor thermo-chemotherapy and imaging. ACS Nano 2016, 10, 984–997.
Crossref Google Scholar
15

Zhang, C.; Fu, Y. Y.; Zhang, X. J.; Yu, C. S.; Zhao, Y.; Sun, S. K. BSA-directed synthesis of CuS nanoparticles as a biocompatible photothermal agent for tumor ablation in vivo. Dalton T. 2015, 44, 13112–13118.
Crossref Google Scholar
16

Yang, T.; Wang, Y.; Ke, H. T.; Wang, Q. L.; Lv, X. Y.; Wu, H.; Tang, Y. A.; Yang, X. L.; Chen, C. Y.; Zhao, Y. L. et al. Protein-nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Adv. Mater. 2016, 28, 5923–5930.
Crossref Google Scholar
17

Chen, W. S.; Ouyang, J.; Liu, H.; Chen, M.; Zeng, K.; Sheng, J. P.; Liu, Z. J.; Han, Y. J.; Wang, L. Q.; Li, J. et al. Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer. Adv. Mater. 2017, 29, 1603864.
Crossref Google Scholar
18

Lovell, J. F.; Jin, C. S.; Huynh, E.; Jin, H.; Kim, C.; Rubinstein, J. L.; Chan, W. C.; Cao, W. G.; Wang, L. V.; Zheng, G. Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents. Nat. Mater. 2011, 10, 324–332.
Crossref Google Scholar
19

Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and drug delivery using theranostic nanoparticles. Adv. Drug Deliver. Rev. 2010, 62, 1052–1063.
Crossref Google Scholar
20

Yang, K.; Yang, G. B.; Chen, L.; Cheng, L.; Wang, L.; Ge, C. C.; Liu, Z. FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy. Biomaterials 2015, 38, 1–9.
Crossref Google Scholar
21

Zhang, Z. J.; Wang, J.; Chen, C. Y. Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv. Mater. 2013, 25, 3869–3880.
Crossref Google Scholar
22

Wang, L. R.; Zhu, X. L.; Tang, X. Y.; Wu, C. Q.; Zhou, Z. J.; Sun, C. J.; Deng, S. L.; Ai, H.; Gao, J. H. A multiple gadolinium complex decorated fullerene as a highly sensitive T1 contrast agent. Chem. Commun. 2015, 51, 4390–4393.
Crossref Google Scholar
23

Rieke, V.; Butts Pauly, K. MR thermometry. J. Magn. Reson. Imaging 2008, 27, 376–390.
Crossref Google Scholar
24

Tian, Q. W.; Hu, J. Q.; Zhu, Y. H.; Zou, R. J.; Chen, Z. G.; Yang, S. P.; Li, R. W.; Su, Q. Q.; Han, Y.; Liu, X. G. Sub-10 nm Fe3O4@Cu2-xS core-shell nanoparticles for dual-modal imaging and photothermal therapy. J. Am. Chem. Soc. 2013, 135, 8571–8577.
Crossref Google Scholar
25

Fu, G. L.; Liu, W.; Li, Y. Y.; Jin, Y. S.; Jiang, L. D.; Liang, X. L.; Feng, S. S.; Dai, Z. F. Magnetic prussian blue nanoparticles for targeted photothermal therapy under magnetic resonance imaging guidance. Bioconjugate Chem. 2014, 25, 1655–1663.
Crossref Google Scholar
26

Song, G. S.; Liang, C.; Gong, H.; Li, M. F.; Zheng, X. C.; Cheng, L.; Yang, K.; Jiang, X. Q.; Liu, Z. Core-shell MnSe@Bi2Se3 fabricated via a cation exchange method as novel nanotheranostics for multimodal imaging and synergistic thermoradiotherapy. Adv. Mater. 2015, 27, 6110–6117.
Crossref Google Scholar
27

Song, X. R.; Wang, X. Y.; Yu, S. X.; Cao, J. B.; Li, S. H.; Li, J.; Liu, G.; Yang, H. H.; Chen, X. Y. Co9Se8 nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy. Adv. Mater. 2015, 27, 3285–3291.
Crossref Google Scholar
28

Xie, J.; Lee, S.; Chen, X. Y. Nanoparticle-based theranostic agents. Adv. Drug Deliver. Rev. 2010, 62, 1064–1079.
Crossref Google Scholar
29

Menon, J. U.; Jadeja, P.; Tambe, P.; Vu, K.; Yuan, B. H.; Nguyen, K. T. Nanomaterials for photo-based diagnostic and therapeutic applications. Theranostics 2013, 3, 152–166.
Crossref Google Scholar
30

Parkes, L. M.; Hodgson, R.; Lu, L. T.; Tung, L. D.; Robinson, I.; Fernig, D. G.; Thanh, N. T. K. Cobalt nanoparticles as a novel magnetic resonance contrast agent-relaxivities at 1.5 and 3 Tesla. Contrast Media Mol. I. 2008, 3, 150–156.
Crossref Google Scholar
31

Li, B.; Yuan, F. K.; He, G. J.; Han, X. Y.; Wang, X.; Qin, J. B.; Guo, Z. X.; Lu, X. W.; Wang, Q.; Parkin, I. P. et al. Ultrasmall CuCo2S4 nanocrystals: All-in-one theragnosis nanoplatform with magnetic resonance/near-infrared imaging for efficiently photothermal therapy of tumors. Adv. Funct. Mater. 2017, 27, 1606218.
Crossref Google Scholar
32

Huang, X. J.; Deng, G. Y.; Liao, L. J.; Zhang, W. L.; Guan, G. Q.; Zhou, F.; Xiao, Z. Y.; Zou, R. J.; Wang, Q.; Hu, J. Q. CuCo2S4 nanocrystals: A new platform for multimodal imaging guided photothermal therapy. Nanoscale 2017, 9, 2626–2632.
Crossref Google Scholar
33

Yang, Z. S.; Chen, C. Y.; Chang, H. T. Supercapacitors incorporating hollow cobalt sulfide hexagonal nanosheets. J. Power Sources 2011, 196, 7874–7877.
Crossref Google Scholar
34

Sun, L.; Lin, Z.; Peng, J.; Weng, J.; Huang, Y.; Luo, Z. Preparation of few-layer bismuth selenide by liquid-phase-exfoliation and its optical absorption properties. Sci. Rep. 2014, 4, 4794.
Crossref Google Scholar
35

Li, Z. L.; Zeng, Y. Y.; Zhang, D.; Wu, M.; Wu, L. J.; Huang, A. M.; Yang, H. H.; Liu, X. L.; Liu, J. F. Glypican-3 antibody functionalized prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma. J. Mater. Chem. B 2014, 2, 3686–3696.
Crossref Google Scholar
36

Roper, D. K.; Ahn, W.; Hoepfner, M. Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles. J. Phys. Chem. C 2007, 111, 3636–3641.
Crossref Google Scholar
37

Hessel, C. M.; Pattani, V. P.; Rasch, M.; Panthani, M. G.; Koo, B.; Tunnell, J. W.; Korgel, B. A. Copper selenide nanocrystals for photothermal therapy. Nano Lett. 2011, 11, 2560–2566.
Crossref Google Scholar
38

Wang, L. V.; Hu, S. Photoacoustic tomography: In vivo imaging from organelles to organs. Science 2012, 335, 1458–1462.
Crossref Google Scholar
39

Chen, J. Q.; Liu, C. B.; Hu, D. H.; Wang, F.; Wu, H. W.; Gong, X. J.; Liu, X.; Song, L.; Sheng, Z. H.; Zheng, H. R. Single-layer MoS2 nanosheets with amplified photoacoustic effect for highly sensitive photoacoustic imaging of orthotopic brain tumors. Adv. Funct. Mater. 2016, 26, 8715–8725.
Crossref Google Scholar
40

Wang, X. G.; Dong, Z. Y.; Cheng, H.; Wan, S. S.; Chen, W. H.; Zou, M. Z.; Huo, J. W.; Deng, H. X.; Zhang, X. Z. A multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy. Nanoscale 2015, 7, 16061–16070.
Crossref Google Scholar
41

Zhang, X. D.; Chen, J.; Min, Y.; Park, G. B.; Shen, X.; Song, S. S.; Sun, Y. M.; Wang, H.; Long, W.; Xie, J. P. et al. Metabolizable Bi2Se3 nanoplates: Biodistribution, toxicity, and uses for cancer radiation therapy and imaging. Adv. Funct. Mater. 2014, 24, 1718–1729.
Crossref Google Scholar
42

Zhang, X. D.; Luo, Z. T.; Chen, J.; Shen, X.; Song, S. S.; Sun, Y. M.; Fan, S. J.; Fan, F. Y.; Leong, D. T.; Xie, J. P. Ultrasmall Au10–12(SG)10–12 nanomolecules for high tumor specificity and cancer radiotherapy. Adv. Mater. 2014, 26, 4565–4568.
Crossref Google Scholar
Nano Research
Volume 11 Issue 5,
May 2018
Pages 2436-2449
DOI: 10.1007/s12274-017-1865-z
Cite this article:
Li Z, Li Z, Chen L, et al. Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging. Nano Research, 2018, 11(5): 2436-2449. https://doi.org/10.1007/s12274-017-1865-z

743

Views

36

Crossref

N/A

Web of Science

36

Scopus

4

CSCD

Altmetrics
Received: 12 June 2017
Revised: 21 September 2017
Accepted: 23 September 2017
Published: 12 May 2018
© Tsinghua University Press and Springer-Verlag GmbH Germany 2017
Return