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Research Article

Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields

Junying Wang1,§, Xiaoju Cui2,3,4,§, Haobo Li2,4,§, Jianping Xiao2, Jiang Yang6, Xiaoyu Mu1, Haixia Liu1, Yuan-Ming Sun5, Xuhui Xue5, Changlong Liu1, Xiao-Dong Zhang1( ), Dehui Deng2,3( ), Xinhe Bao2
Department of PhysicsTianjin Key Laboratory of Low Dimensional Materials Physics and Preparing TechnologySchool of ScienceTianjin UniversityTianjin300350China
State Key Laboratory of CatalysisCollaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China
State Key Laboratory for Physical Chemistry of Solid SurfacesCollaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China
University of Chinese Academy of SciencesBeijing100039China
Tianjin Key Laboratory of Molecular Nuclear MedicineInstitute of Radiation MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China
State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou510060China

§ Junying Wang, Xiaoju Cui, and Haobo Li contributed equally to this work.

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Graphical Abstract

Abstract

Normal levels of oxygen free radicals play an important role in cellular signal transduction, redox homeostasis, regulatory pathways, and metabolic processes. However, radiolysis of water induced by high-energy radiation can produce excessive amounts of exogenous oxygen free radicals, which cause severe oxidative damages to all cellular components, disrupt cellular structures and signaling pathways, and eventually lead to death. Herein, we show that hybrid nanoshields based on single-layer graphene encapsulating metal nanoparticles exhibit high catalytic activity in scavenging oxygen superoxide(·O2-), hydroxyl (·OH), and hydroperoxyl (HO2·) free radicals via electron transfer between the single-layer graphene and the metal core, thus achieving biocatalytic scavenging both in vitro and in vivo. The levels of the superoxide enzyme, DNA, and reactive oxygen species measured in vivo clearly show that the nanoshields can efficiently eliminate harmful oxygen free radicals at the cellular level, both in organs and circulating blood. Moreover, the nanoshieldslead to an increase in the overall survival rate of gamma ray-irradiated mice to up to 90%, showing the great potential of these systems as protective agentsagainst ionizing radiation.

Keywords

biocatalytic processesradiation protectiongraphene-encapsulated metal nanoparticlesoxygen free radicalDFT calculations

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Nano Research
Volume 11 Issue 5,
May 2018
Pages 2821-2835
DOI: 10.1007/s12274-017-1912-9
Cite this article:
Wang J, Cui X, Li H, et al. Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields. Nano Research, 2018, 11(5): 2821-2835. https://doi.org/10.1007/s12274-017-1912-9

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Received: 03 October 2017
Revised: 25 October 2017
Accepted: 04 November 2017
Published: 12 May 2018
© Tsinghua University Press and Springer-Verlag GmbH Germany 2017
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