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Review Article

Biomedical applications of mRNA nanomedicine

Qingqing Xiong1,2Gha Young Lee1Jianxun Ding1Wenliang Li1,3Jinjun Shi1( )
Center for Nanomedicine and Department of AnesthesiologyBrigham and Women's HospitalHarvard Medical SchoolBostonMA02115USA
Department of Hepatobiliary CancerTianjin Medical University Cancer Institute & HospitalTianjin300060China
School of PharmacyJilin Medical UniversityJilin132013China
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Graphical Abstract

Abstract

As an attractive alternative to plasmid DNA, messenger RNA (mRNA) has recently emerged as a promising class of nucleic acid therapeutics for biomedical applications. Advances in addressing the inherent shortcomings of mRNA and in the development of nanoparticle-based delivery systems have prompted the development and clinical translation of mRNA-based medicines. In this review, we discuss the chemical modification strategies of mRNA to improve its stability, minimize immune responses, and enhance translational efficacy. We also highlight recent progress in nanoparticle-based mRNA delivery. Considerable attention is given to the increasingly widespread applications of mRNA nanomedicine in the biomedical fields of vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.

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Nano Research
Pages 5281-5309
Cite this article:
Xiong Q, Lee GY, Ding J, et al. Biomedical applications of mRNA nanomedicine. Nano Research, 2018, 11(10): 5281-5309. https://doi.org/10.1007/s12274-018-2146-1
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Received: 20 April 2018
Revised: 02 July 2018
Accepted: 08 July 2018
Published: 27 July 2018
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018
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