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Research Article

Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Wenjun Zhu1,§, Yu Yang2,§, Qiutong Jin1, Yu Chao1, Longlong Tian1, Jingjing Liu1, Ziliang Dong1, Zhuang Liu1( )
Institute of Functional Nano & Soft Materials (FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University,Suzhou,215123,China;
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences,University of Macau, Avenida da Universidad,Taipa, Macau,31608,China;

§ Wenjun Zhu and Yu Yang contributed equally to this work.

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Graphical Abstract

Abstract

Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D NMOFs could be labeled with a diagnostic radioisotope, 99mTc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D NMOFs for nanomedicine applications.

Keywords

nanoscale metal-organic-frameworktwo-dimensional nanosheetsdrug deliveryphotodynamic therapycombination

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Nano Research
Volume 12 Issue 6,
June 2019
Pages 1307-1312
DOI: 10.1007/s12274-018-2242-2
Cite this article:
Zhu W, Yang Y, Jin Q, et al. Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy. Nano Research, 2019, 12(6): 1307-1312. https://doi.org/10.1007/s12274-018-2242-2
Topics:
Biodegradability BiodegradationChemotherapy Crystalline materials DiagnosisDrug deliveryMedical nanotechnologyOrganic polymersOrganometallics
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Received: 11 September 2018
Revised: 30 October 2018
Accepted: 06 November 2018
Published: 29 May 2019
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018
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