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Research Article

All in one theranostic nanoplatform enables efficient anti-tumor peptide delivery for triple-modal imaging guided cancer therapy

Xiaoyan Qu1, Zhengqing Liu2, Bohan Ma1, Na Li1,4, Hongyang Zhao1, Tian Yang3, Yumeng Xue1, Xiaozhi Zhang3, Yongping Shao1, Ying Chang1, Jun Xu2, Bo Lei1(), Yaping Du2()
Frontier Institute of Science and Technology,Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi'an Jiaotong University,Xi'an,710000,China;
School of Materials Science and Engineering,National Institute for Advanced Materials, Center for Rare Earth and Inorganic Functional Materials, Nankai University,Tianjin,300350,China;
Department of Radiation Oncology,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710000,China;
Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA
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Abstract

Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.

Keywords

rare earth nanoparticlesmultifunctional propertypeptide deliverytumor imagingtumor therapy

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Nano Research
Volume 12 Issue 3,
March 2019
Pages 593-599
DOI: 10.1007/s12274-018-2261-z
Cite this article:
Qu X, Liu Z, Ma B, et al. All in one theranostic nanoplatform enables efficient anti-tumor peptide delivery for triple-modal imaging guided cancer therapy. Nano Research, 2019, 12(3): 593-599. https://doi.org/10.1007/s12274-018-2261-z
Topics:
Cell death CytotoxicityDiseasesDrug interactionsEuropium compoundsGadolinium compoundsLanthanum compoundsMagnetic resonance imagingNanoparticlesOncologyPeptidesRare earthsSodium compoundsTargeted drug deliveryTumors
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