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Research Article

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

Dawei Jiang1,2,§, Hyung-Jun Im1,3,§, Madeline E. Boleyn1,4,§, Christopher G. England1, Dalong Ni1, Lei Kang1,5, Jonathan W. Engle1, Peng Huang2 ( ), Xiaoli Lan6( ), Weibo Cai1( )
Departments of Radiology and Medical Physics,University of Wisconsin-Madison,Madison, Wisconsin,53705,USA;
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University,Shenzhen,518060,China;
Graduate School of Convergence Science and Technology,Seoul National University,Seoul,08826,Republic of Korea;
Departments of Mathematics, and Biology,University of Wisconsin-Madison,Wisconsin,53705,USA;
Department of Nuclear Medicine,Peking University First Hospital,Beijing,100034,China;
Department of Nuclear Medicine,Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave,Wuhan,430022,China;

§Dawei Jiang, Hyung-Jun Im, and Madeline E. Boleyn contributed equally to this work.

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Graphical Abstract

Abstract

DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN's transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.

Keywords

positron emission tomography (PET) imagingDNA nanotechnologyDNA tetrahedron nanoparticlerenal clearancekidney dysfunction

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Nano Research
Volume 12 Issue 3,
March 2019
Pages 637-642
DOI: 10.1007/s12274-019-2271-5
Cite this article:
Jiang D, Im H-J, Boleyn ME, et al. Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function. Nano Research, 2019, 12(3): 637-642. https://doi.org/10.1007/s12274-019-2271-5
Topics:
DNA MammalsMedical applicationsNanoparticlesPositrons

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Received: 08 October 2018
Revised: 04 December 2018
Accepted: 15 December 2018
Published: 28 December 2018
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
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