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Research Article

Real-time Raman detection by the cavity mode enhanced Raman scattering

Yang Liu1,2,3, Xiaorui Tian4, Weiran Guo1,2,3, Wenqiang Wang1,2,3, Zhiqiang Guan1,2,3( ), Hongxing Xu1,2,3,5( )
School of Physics and Technology,Wuhan University,Wuhan,430072,China;
Center for Nanoscience and Nanotechnology,Wuhan University,Wuhan,430072,China;
Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education,Wuhan University,Wuhan,430072,China;
College of Chemistry,Chemical Engineering and Materials Science, Shandong Normal University,Jinan,250014,China;
The Institute for Advanced Studies,Wuhan University,Wuhan,430072,China;
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Abstract

Integrating surface enhanced Raman scattering (SERS) with microfluidics is the long-term goal for reduced volume, multiplex and automation fingerprint detection of biomolecules. High sensitivity, repeatability, stability, reusability and real-time detection are the performance goals of Raman detection in the aqueous solution environment. Here, we reported the study on cavity mode enhanced SERS detection of both surface-adsorbed molecules and non-surface-adsorbed molecules in the solution environment. The cavity modes had important influence on the SERS enhancement, especially for the non-surface adsorbed molecules. Uniform, repeatable, reusable and real-time Raman signal detection of the non-surface adsorbed Rhodamine 6G molecules was demonstrated. Our work is an important step for the practical on-chip microfluidic Raman detection applications.

Keywords

surface enhanced Raman scatteringcavity modesmicrofluidicsbi-analytereal-time detection

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Nano Research
Volume 12 Issue 7,
July 2019
Pages 1643-1649
DOI: 10.1007/s12274-019-2414-8
Cite this article:
Liu Y, Tian X, Guo W, et al. Real-time Raman detection by the cavity mode enhanced Raman scattering. Nano Research, 2019, 12(7): 1643-1649. https://doi.org/10.1007/s12274-019-2414-8
Topics:
Raman scatteringRaman spectroscopySignal detection

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Received: 24 December 2018
Revised: 17 March 2019
Accepted: 10 April 2019
Published: 25 April 2019
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
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