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Research Article

Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

Nian Liu1,2,3,§, Yiyue Shi1,§, Jingru Guo1, Hai Li4, Qiang Wang5, Menglin Song3, Zhiyuan Shi3, Le He4, Xinhui Su5, Jin Xie6, Xiaolian Sun1( )
State Key Laboratory of Natural MedicinesKey Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing210009China
Institute of Biological and Medical ImagingHelmholtz Zentrum München and Technische Universit?t MünchenNeuherberg85764Germany
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen361005China
Institute of Functional Nano & Soft Materials (FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow UniversitySuzhou215123China
Department of Nuclear MedicineZhongshan Hospital Xiamen UniversityXiamen361004China
Department of ChemistryBio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia30602USA

§Nian Liu and Yiyue Shi contributed equally to this work.

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Abstract

Nanoparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications. We prepared 2.5 nm tyrosine based carbon dots (TCDs) with phenolic hydroxyl groups on the surface for directly 125I labeling. The 125I labeled polyethylene glycol (PEG) functionalized TCDs (125I-TCDPEGs) showed excellent radiochemical stability both in vitro and in vivo. Due to the enhanced permeability and retention effect, these 125I-TCDPEGs demonstrated a tumor accumulation around 4%-5% of the injected dose per gram (ID/g) for U87MG, 4T1, HepG2 and MCF7 tumor-bearing mice at 1 h post-injection. Meanwhile, the 125I-TCDPEGs also could be fast renally excreted, with less than 0.6% ID/g left in the liver and spleen within 24 h. These radioactive carbon dots not only can be used for cellular fluorescence imaging due to their intrinsic optical property, but are also effective single photon emission computed tomography (SPECT) imaging agents for tumor. Together with their excellent biocompatibility and stability, we anticipate these 125I-TCDPEGs of great potential for early tumor diagnosis in clinic. What's more, our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I for different biomedical application.

Keywords

radioiodinationtyrosine based carbon dotssingle photon emission computed tomography (SPECT) imagingfluoresecent imagingrenal clearance

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References

1

Charlton, K. A sustainable future for nuclear imaging. Nat. Rev. Phys. 2019, 1, 530-532.
Crossref Google Scholar
2
Zeglis, B. M. ; Holland, J. P. ; Lebedev, A. Y. ; Cantorias, M. V. ; Lewis, J. S. Radiopharmaceuticals for imaging in oncology with special emphasis on positron-emitting agents In Nuclear Oncology: Pathophysiology and Clinical Applications. Strauss, H. W. ; Mariani, G. ; Volterrani D. ; Larson S. M., Eds. ; Springer: New York, 2013; pp 35-78.https://doi.org/10.1007/978-0-387-48894-3_3
Crossref
3

Dunphy, M. P. ; Lewis, J. S. Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET. J. Nucl. Med. 2009, 50 Suppl 1, 106S-121S.
Crossref Google Scholar
4

Park, S. M. ; Aalipour, A. ; Vermesh, O. ; Yu, J. H. ; Gambhir, S. S. Towards clinically translatable in vivo nanodiagnostics. Nat. Rev. Mater. 2017, 2, 17014.
Crossref Google Scholar
5

Sun, X. L. ; Cai, W. B. ; Chen, X. Y. Positron emission tomography imaging using radiolabeled inorganic nanomaterials. Acc. Chem. Res. 2015, 48, 286-294.
Crossref Google Scholar
6

Pampaloni, M. H. ; Nardo, L. PET/MRI radiotracer beyond 18F-FDG. PET Clin. 2014, 9, 345-349.
Crossref Google Scholar
7

Mushtaq, S. ; Jeon, J. ; Shaheen, A. ; Jang, B. S. ; Park, S. H. Critical analysis of radioiodination techniques for micro and macro organic molecules. J. Radioanal. Nucl. Chem. 2016, 309, 859-889.
Crossref Google Scholar
8

Cavina, L. ; van der Born, D. ; Klaren, P. H. M. ; Feiters, M. C. ; Boerman, O. C. ; Rutjes, F. P. J. T. Design of radioiodinated pharmaceuticals: Structural features affecting metabolic stability towards in vivo deiodination. Eur. J. Org. Chem. 2017, 2017, 3387-3414.
Crossref Google Scholar
9

Seevers, R. H. ; Counsell, R. E. Radioiodination techniques for small organic molecules. Chem. Rev. 1982, 82, 575-590.
Crossref Google Scholar
10
Bailey, G. S. Labeling of peptides and proteins by radioiodination. In Basic Protein and Peptide Protocols. Walker, J. M., Ed. ; Springer: Humana Press, 1994; pp 441-448.https://doi.org/10.1385/0-89603-268-X:441
Crossref
11
Dewanjee, M. K. Methods of radioiodination reactions with several oxidizing agents. In Radioiodination: Theory, Practice, and Biomedical Applications. Dewanjee, M. K., Ed. ; Springer: Boston, MA, 1992; pp 129-218.https://doi.org/10.1007/978-1-4615-3508-9_8
Crossref
12

Yi, X. ; Xu, M. Y. ; Zhou, H. L. ; Xiong, S. S. ; Qian, R. ; Chai, Z. F. ; Zhao, L. ; Yang, K. Ultrasmall hyperbranched semiconducting polymer nanoparticles with different radioisotopes labeling for cancer theranostics. ACS Nano2018, 12, 9142-9151.
Crossref Google Scholar
13

Song, M. L. ; Liu, N. ; He, L. ; Liu, G. ; Ling, D. S. ; Su, X. H. ; Sun, X. L. Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy. Nano Res. 2018, 11, 2196-2808.
Crossref Google Scholar
14

Yi, X. ; Yang, K. ; Liang, C. ; Zhong, X. Y. ; Ning, P. ; Song, G. S. ; Wang, D. L. ; Ge, C. C. ; Chen, C. Y. ; Chai, Z. F. et al. Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles. Adv. Funct. Mater. 2015, 25, 4689-4699.
Crossref Google Scholar
15

Phillips, E. ; Penate-Medina, O. ; Zanzonico, P. B. ; Carvajal, R. D. ; Mohan, P. ; Ye, Y. P. ; Humm, J. ; Gönen, M. ; Kalaigian, H. ; Schoder, H. et al. Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe. Sci. Transl. Med. 2014, 6, 260ra149.
Crossref Google Scholar
16

Zhou, M. ; Li, J. J. ; Liang, S. ; Sood, A. K. ; Liang, D. ; Li, C. CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy. ACS Nano2015, 9, 7085-7096.
Crossref Google Scholar
17

Wen, L. ; Chen, L. ; Zheng, S. M. ; Zeng, J. F. ; Duan, G. X. ; Wang, Y. ; Wang, G. L. ; Chai, Z. F. ; Li, Z. ; Gao, M. Y. Ultrasmall biocompatible WO3-x nanodots for multi-modality imaging and combined therapy of cancers. Adv. Mater. 2016, 28, 5072-5079.
Crossref Google Scholar
18

Shen, S. D. ; Jiang, D. W. ; Cheng, L. ; Chao, Y. ; Nie, K. Q. ; Dong, Z. L. ; Kutyreff, C. J. ; Engle, J. W. ; Huang, P. ; Cai, W. B. et al. Renal-clearable ultrasmall coordination polymer nanodots for chelator-free 64Cu-labeling and imaging-guided enhanced radiotherapy of cancer. ACS Nano2017, 11, 9103-9111.
Crossref Google Scholar
19

Chen, L. ; Chen, J. Y. ; Qiu, S. S. ; Wen, L. ; Wu, Y. ; Hou, Y. ; Wang, Y. ; Zeng, J. F. ; Feng, Y. ; Li, Z. et al. Biodegradable nanoagents with short biological half-life for SPECT/PAI/MRI multimodality imaging and PTT therapy of tumors. Small2018, 14, 1702700.
Crossref Google Scholar
20

Lu, N. ; Fan, W. P. ; Yi, X. ; Wang, S. ; Wang, Z. T. ; Tian, R. ; Jacobson, O. ; Liu, Y. J. ; Yung, B. C. ; Zhang, G. F. et al. Biodegradable hollow mesoporous organosilica nanotheranostics for mild hyperthermia-induced bubble-enhanced oxygen-sensitized radiotherapy. ACS Nano2018, 12, 1580-1591.
Crossref Google Scholar
21

Chen, D. Q. ; Zhang, G. Q. ; Li, R. M. ; Guan, M. R. ; Wang, X. Y. ; Zou, T. J. ; Zhang, Y. ; Wang, C. R. ; Shu, C. Y. ; Hong, H. et al. Biodegradable, hydrogen peroxide, and glutathione dual responsive nanoparticles for potential programmable paclitaxel release. J. Am. Chem. Soc. 2018, 140, 7373-7376.
Crossref Google Scholar
22

Feng, H. ; Qian, Z. S. Functional carbon quantum dots: A versatile platform for chemosensing and biosensing. Chem. Rec. 2018, 18, 491-505.
Crossref Google Scholar
23

Roy, P. ; Chen, P. C. ; Periasamy, A. P. ; Chen, Y. N. ; Chang, H. T. Photoluminescent carbon nanodots: Synthesis, physicochemical properties and analytical applications. Mater. Today2015, 18, 447-458.
Crossref Google Scholar
24

Yang, S. T. ; Cao, L. ; Luo, P. G. ; Lu, F. S. ; Wang, X. ; Wang, H. F. ; Meziani, M. J. ; Liu, Y. F. ; Qi, G. ; Sun, Y. P. Carbon dots for optical imaging in vivo. J. Am. Chem. Soc. 2009, 131, 11308-11309.
Crossref Google Scholar
25

Huang, P. ; Lin, J. ; Wang, X. S. ; Wang, Z. ; Zhang, C. L. ; He, M. ; Wang, K. ; Chen, F. ; Li, Z. M. ; Shen, G. X. et al. Light-triggered theranostics based on photosensitizer-conjugated carbon dots for simultaneous enhanced-fluorescence imaging and photodynamic therapy. Adv. Mater. 2012, 24, 5104-5110.
Crossref Google Scholar
26

Du, J. J. ; Xu, N. ; Fan, J. L. ; Sun, W. ; Peng, X. J. Carbon dots for in vivo bioimaging and theranostics. Small2019, 15, 1805087.
Crossref Google Scholar
27

Zheng, M. ; Ruan, S. B. ; Liu, S. ; Sun, T. T. ; Qu, D. ; Zhao, H. F. ; Xie, Z. G. ; Gao, H. L. ; Jing, X. B. ; Sun, Z. C. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano2015, 9, 11455-11461.
Crossref Google Scholar
28

Opacic, T. ; Paefgen, V. ; Lammers, T. ; Kiessling, F. Status and trends in the development of clinical diagnostic agents. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2017, 9, e1441.
Crossref Google Scholar
29

Aherne, G. W. ; James, S. L. ; Marks, V. The radioiodination of bleomycin using iodogen. Clin. Chim. Acta1982, 119, 341-343.
Crossref Google Scholar
30

Spetz, J. ; Rudqvist, N. ; Forssell-Aronsson, E. Biodistribution and dosimetry of free 211At, 125I-and 131I-in rats. Cancer Biother. Radiopharm. 2013, 28, 657-664.
Crossref Google Scholar
31

Cranley, K. ; Bell, T. K. 125I thyroid intakes: Consideration of thyroid radiation dose, and air and water concentration limits. Int. J. Appl. Radiat. Isot. 1979, 30, 161-163.
Crossref Google Scholar
32

Zhu, A. Z. ; Yoon, Y. ; Liang, Z. X. ; Voll, R. ; Goodman, M. E. ; Goodman, M. M. ; Shim, H. Abstract 5227: Detection of metastatic potential by a novel small molecule F-18 PET imaging agent. Cancer Res. 2011, 71, 5227.
Crossref Google Scholar
33

Foss, C. A. ; Mease, R. C. ; Fan, H. ; Wang, Y. H. ; Ravert, H. T. ; Dannals, R. F. ; Olszewski, R. T. ; Heston, W. D. ; Kozikowski, A. P. ; Pomper, M. G. Radiolabeled small-molecule ligands for prostate-specific membrane antigen: In vivo imaging in experimental models of prostate cancer. Clin. Cancer Res. 2005, 11, 4022-4028.
Crossref Google Scholar
34

Mankoff, D. A. ; Link, J. M. ; Linden, H. M. ; Sundararajan, L. ; Krohn, K. A. Tumor receptor imaging. J. Nucl. Med. 2008, 49 Suppl 2, 149S-163S.
Crossref Google Scholar
35

Tang, S. H. ; Peng, C. Q. ; Xu, J. ; Du, B. J. ; Wang, Q. X. ; Vinluan Ⅲ, R. D. ; Yu, M. X. ; Kim, M. J. ; Zheng, J. Tailoring renal clearance and tumor targeting of ultrasmall metal nanoparticles with particle density. Angew. Chem., Int. Ed. 2016, 55, 16039-16043.
Crossref Google Scholar
36
Zhao, R. B. ; Keen, L. ; Kong, X. D. Clinical translation and safety regulation of nanobiomaterials In Nanobiomaterials: Classification, Fabrication and Biomedical Applications. Wang X. M. ; Ramalingam M. ; Kong, X. D., Eds. ; Wiley Germany: Verlag, 2017; pp 459-479.https://doi.org/10.1002/9783527698646.ch19
Crossref
Nano Research
Volume 12 Issue 12,
December 2019
Pages 3037-3043
DOI: 10.1007/s12274-019-2549-7
Cite this article:
Liu N, Shi Y, Guo J, et al. Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor. Nano Research, 2019, 12(12): 3037-3043. https://doi.org/10.1007/s12274-019-2549-7
Topics:
BiocompatibilityCarbonDiagnosisFluorescence imagingMammalsMedical applicationsOptical propertiesPhotonsTumors

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Received: 20 September 2019
Revised: 18 October 2019
Accepted: 21 October 2019
Published: 31 October 2019
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
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