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Research Article

GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system

Amin Zhang1,2, Qian Zhang1,2, Gabriel Alfranca1,4, Shaojun Pan2,3, Zhicheng Huang1,2, Jin Cheng1,2, Qiang Ma5, Jie Song1,2, Yunxiang Pan1,2, Jian Ni1,2, Lijun Ma6( ), Daxiang Cui1,2,3( )
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, China
National Center for Translational Medicine, Collaborative Innovational Center for System Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC/Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain
Department of Tumor, Xintai People's Hospital, Xintai 271200, China
Department of Tumor in Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 XianXia Road, Shanghai 200336, China
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Graphical Abstract

Abstract

Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment. In this regard, we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic. The multifunctional probes consisted of a gold/platinum star-shaped core (Au/Pt star) conjugated with a GSH-sensitive disulfide bond (S-S), a targeting ligand (rHSA-FA), a near-infrared fluorophore (IR780) and glucose oxidase (GOx). When systemically administered in a xenografted murine model, the probes specifically targeted the tumor sites. As the disulfide linker was cleaved by intracellular GSH, the IR780 molecules could be released for photo-thermal therapy & photodynamic therapy (PTT&PDT) and imaging. Subsequently, the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system: GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity, and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic ·OH for tumor oxidative damage. Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release, real-time imaging ability, and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features, which provides a potential strategy for effective tumor theragnostic.

Keywords

Au/Pt starGSH-responsiveGOxperoxidasesequential nanocatalystcancer starving-like therapyenzyme oxidative therapyphoto-thermal therapy & photodynamic therapy (PTT&PDT)

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Nano Research
Volume 13 Issue 1,
January 2020
Pages 160-172
DOI: 10.1007/s12274-019-2591-5
Cite this article:
Zhang A, Zhang Q, Alfranca G, et al. GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system. Nano Research, 2020, 13(1): 160-172. https://doi.org/10.1007/s12274-019-2591-5
Topics:
DiseasesGlucoseGlucose oxidaseGlucose sensors Infrared devices NanocatalystsPlatinumProbesSulfur compoundsTumors

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Received: 10 October 2019
Revised: 24 November 2019
Accepted: 29 November 2019
Published: 02 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
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