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Research Article

PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia

Tao Zhang1,§, Zhenqi Jiang2,3,§, Libin Chen4,§, Chunshu Pan2, Shan Sun2, Chuang Liu2, Zihou Li2, Wenzhi Ren2,5( ), Aiguo Wu2( ), Pintong Huang1( )
Department of Ultrasound, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
University of Chinese Academy of Sciences, Beijing 100049, China
Department of Ultrasound, Ningbo First Hospital, Ningbo 315010, China
Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315016, China

§ Tao Zhang, Zhenqi Jiang, and Libin Chen contributed equally to this work.

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Abstract

As nanomedicine-based clinical strategies have continued to develop, the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy (PDT) to treat pancreatic cancer (PaC) has emerged as a viable therapeutic modality. The efficacy of such an approach, however, is likely to be constrained by the mechanisms of drug release and tumor oxygen levels. In the present study, we developed an Fe(III)-complexed porous coordination network (PCN) which we then used to encapsulate PTX (PCN-Fe(III)-PTX) nanoparticles (NPs) in order to treat PaC via a combination of chemotherapy and PDT. The resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within tumors. Furthermore, through a Fe(III)-based Fenton-like reaction these NPs were able to convert H2O2 in the tumor site to O2, thereby regulating local hypoxic conditions and enhancing the efficacy of PDT approaches. Also these NPs were suitable for use as a T1-magnetic resonance imaging (MRI) weighted contrast agent, making them viable for monitoring therapeutic efficacy upon treatment. Our results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT, giving them great promise for the clinical treatment of PaC.

Keywords

hypoxiaporous-coordination polymersmagnetic resonance imaging (MRI) imagingphotodynamic therapychemocherapy

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Nano Research
Volume 13 Issue 1,
January 2020
Pages 273-281
DOI: 10.1007/s12274-019-2610-6
Cite this article:
Zhang T, Jiang Z, Chen L, et al. PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia. Nano Research, 2020, 13(1): 273-281. https://doi.org/10.1007/s12274-019-2610-6
Topics:
Cell cultureChemotherapy Controlled drug deliveryDiseasesMagnetic resonance imagingMedical nanotechnologyNanoparticlesOxidationOxygenTargeted drug deliveryTumors

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Received: 19 October 2019
Revised: 11 December 2019
Accepted: 15 December 2019
Published: 02 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019
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