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Research Article

Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive

Zhao Pan1, Kai-Run Zhang3, Huai-Ling Gao1, Yong Zhou3, Bei-Bei Yan1, Chi Yang2, Zhi-Yuan Zhang2, Liang Dong1, Si-Ming Chen1, Rui Xu3, Duo-Hong Zou2,3( ), Shu-Hong Yu1 ( )
Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Nanoscience, Hefei Science Center of CAS, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
Department of Oral Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatologic Hospital & College, Anhui Medical University, Heifei 230032, China
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Abstract

Efficient initiation and resolution of inflammation are crucial for wound repair. However, with using tissue adhesives for wound repair, patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic inflammation. As the demand for minimal invasive therapy continues to rise, desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly urgent. Herein, by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles (MSNs), we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue reformation. With formation of nanocomposites in wound gaps, the injured tissues can get reconnected conveniently. The resultant accelerated healing process verify that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound repair. This design strategy will inspire more innovative tissue adhesives for clinical applications.

Keywords

mesoporous nanoparticletissue adhesivewound repairinflammationaccelerated healing

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Nano Research
Volume 13 Issue 2,
February 2020
Pages 373-379
DOI: 10.1007/s12274-020-2619-x
Cite this article:
Pan Z, Zhang K-R, Gao H-L, et al. Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive. Nano Research, 2020, 13(2): 373-379. https://doi.org/10.1007/s12274-020-2619-x
Topics:
Mesoporous materials NanoparticlesPathologySilicaSilica nanoparticles

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Received: 21 July 2019
Revised: 17 December 2019
Accepted: 21 December 2019
Published: 17 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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