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Research Article

Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing

Hao Qiu1,2, Fang Pu1( ), Zhengwei Liu1,3, Xuemeng Liu1,2, Kai Dong1, Chaoqun Liu1, Jinsong Ren1,2( ), Xiaogang Qu1,2( )
State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
University of Science and Technology of China, Hefei 230026, China
University of Chinese Academy of Sciences, Beijing 100039, China
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Abstract

Artificial enzymes have provided great antimicrobial activity to combat wound infection. However, the lack of tissue repair capability compromised their treatment effect. Therefore, development of novel artificial enzyme concurrently with the excellent antibacterial activity and the property of promoting wound healing are required. Here, we demonstrated the hydrogel-based artificial enzyme composed of copper and amino acids possessed intrinsic peroxidase-like catalytic activity, which could combat wound pathogen effectively and accelerate wound healing by stimulating angiogenesis and collagen deposition. Furthermore, the system possesses good biocompatibility for practical application. The synergic effect of the hydrogel-based artificial enzyme promises the system as a new paradigm in bacteria-infected wound healing therapy.

Keywords

hydrogel-based artificial enzymeperoxidase-like activitywound healinganti-bacteria

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Nano Research
Volume 13 Issue 2,
February 2020
Pages 496-502
DOI: 10.1007/s12274-020-2636-9
Cite this article:
Qiu H, Pu F, Liu Z, et al. Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing. Nano Research, 2020, 13(2): 496-502. https://doi.org/10.1007/s12274-020-2636-9
Topics:
Bacteria BiocompatibilityCatalyst activityTissue regeneration

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Received: 29 November 2019
Revised: 29 November 2019
Accepted: 01 January 2020
Published: 17 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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