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Research Article

Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging

Ye Yuan1,2,§, Ruonan Bo2,3,§, Di Jing2,4, Zhao Ma2, Zhongling Wang2,5, Tzu-yin Lin6, Lijie Dong1, Xiangdong Xue2,7( ), Yuanpei Li2( )
Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA
School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento 95817, USA
College of Life Sciences, Northwest University, Xi’an 710069, China

§ Ye Yuan and Ruonan Bo contributed equally to this work.

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Graphical Abstract

Abstract

Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials. Here, we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy, in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any carriers. The building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs (7-ethyl-10-hydroxy-camptothecin, SN-38) with a photosensitizer (porphyrin) via hydrolyzable ester linkage, which endows the drug delivery system with 100% active pharmaceutical ingredients, excellent imaging, and therapeutic functionalities. The conjugates can readily self-assemble into nanosheets (PS NSs) and remain stable for at least 20 days in aqueous solution. In PS NSs, fluorescence resonance energy transfer (FRET) dominates the fluorescence of SN-38 and enables to monitor the drug release fluorescently. The PS NSs also show excellent anticancer activity in vitro, due to the increased cell uptake with the synergistic effect of photodynamic therapy and chemotherapy.

Keywords

drug deliveryphotodynamic therapyporphyrin7-ethyl-10-hydroxy-camptothecin (SN-38)self-indicationnanotheranostics

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Nano Research
Volume 13 Issue 2,
February 2020
Pages 503-510
DOI: 10.1007/s12274-020-2641-z
Cite this article:
Yuan Y, Bo R, Jing D, et al. Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging. Nano Research, 2020, 13(2): 503-510. https://doi.org/10.1007/s12274-020-2641-z
Topics:
Chemotherapy Controlled drug deliveryDiseasesDrug deliveryDrug products

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Received: 21 October 2019
Revised: 05 January 2020
Accepted: 05 January 2020
Published: 16 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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