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Research Article

Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/ photothermal therapy

Li Zhang1,§, Zhe Yang1,§, Jinghua Ren4, Li Ba4, Wenshan He2( ), Chun-Yuen Wong1,3( )
Department of Chemistry, City University of Hong Kong, Hong Kong, China
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, Hong Kong, China
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

§ Li Zhang and Zhe Yang contributed equally to this work.

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Graphical Abstract

Abstract

The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted much interest in recent years, but non-specific distribution of photosensitizers and intrinsic tumor hypoxic microenvironment have continued to limit its therapeutic efficiency. We herein report a nano-theranostic system, denoted as Ce6-CuS/MSN@PDA@MnO2-FA NPs, which combines PDT, PTT, magnetic resonance (MR) imaging with hypoxia-relieving and tumor-targeting functionalities. Central to this design is the use of mussel-inspired polydopamine (PDA) coating to encapsulate the chlorin e6 (Ce6) and copper sulfide nanoparticles (CuS NPs) loaded mesoporous silica nanoparticle (MSN) core. The PDA coating not only acts as pH sensitive gatekeeper to prevent the premature release of Ce6 under non-acidic tumor microenvironment (TME), but also facilitates post-functionalization so that hypoxia-relieving MnO2 nano-sheets and tumor-targeting ligand folic acid-PEG-thiol (FA-PEG-SH) can be decorated on the outer part of the drug system. In vitro and in vivo measurements clearly demonstrated that all these functionalities worked synergistically as expected. The system, having a low dark cytotoxicity, can be effectively internalized by 4T1 cells and decrease the cell viability to 2% upon 660 nm/808 nm laser irradiation. Tumors in 4T1 tumor-bearing mice can almost be completely destroyed in 2 weeks via combined PDT/PTT. Together with the TME-sensitive MR imaging performance demonstrated, Ce6-CuS/MSN@PDA@MnO2-FA NPs represent a multifunctional prototype which holds great potential to be developed into clinical theranostics.

Keywords

hypoxia reliefMnO2 nano-sheetphotodynamic therapyphotothermal therapymagnetic resonance imaging

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Nano Research
Volume 13 Issue 5,
May 2020
Pages 1389-1398
DOI: 10.1007/s12274-020-2646-7
Cite this article:
Zhang L, Yang Z, Ren J, et al. Multifunctional oxygen-enriching nano-theranostics for cancer-specific magnetic resonance imaging and enhanced photodynamic/ photothermal therapy. Nano Research, 2020, 13(5): 1389-1398. https://doi.org/10.1007/s12274-020-2646-7
Topics:
Cerium compoundsCoatings Copper compoundsMagnetic resonance imagingMagnetism MammalsManganese oxideNanoparticlesNanosheetsOxygenSilicaSilica nanoparticlesSulfur compoundsTargeted drug deliveryTumors

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Received: 31 October 2019
Revised: 31 December 2019
Accepted: 07 January 2020
Published: 23 January 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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