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Review Article

Progress in transdermal drug delivery systems for cancer therapy

Tianyue Jiang1, Guo Xu1, Guojun Chen2,3, Yu Zheng1, Bingfang He1( ), Zhen Gu2,3( )
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Jonsson Comprehensive Cancer Center and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
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Graphical Abstract

Abstract

Transdermal drug delivery is an appealing option except for oral and hypodermic administration. With the advancement of skin penetration strategies, various anticancer therapeutics ranging from lipophilic small-molecule drugs to hydrophilic biomacromolecules, can be administered transdermally, offering an optional regimen to treat skin cancers. In addition, the activation of the skin immune systems can also assist the treatment of distal sites. Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review. We also survey recent advances in micro- and nanotechnology-based transdermal formulations for cancer treatment, such as chemotherapy, gene therapy, immunotherapy, phototherapy and combination therapy. New penetration enhancers, materials, formulations and their hypothesized mechanisms for transdermal delivery are highlighted. Advantages and limitations regarding the state-of-the-art transdermal delivery technologies, as well as future perspective are also discussed.

Keywords

drug deliverytransdermal deliverycancer therapychemotherapyimmunotherapycombination therapy

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Nano Research
Volume 13 Issue 7,
July 2020
Pages 1810-1824
DOI: 10.1007/s12274-020-2664-5
Cite this article:
Jiang T, Xu G, Chen G, et al. Progress in transdermal drug delivery systems for cancer therapy. Nano Research, 2020, 13(7): 1810-1824. https://doi.org/10.1007/s12274-020-2664-5
Topics:
Chemotherapy DiseasesDrug deliveryDrug productsGene therapy OncologyTargeted drug delivery
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Received: 13 December 2019
Revised: 16 January 2020
Accepted: 16 January 2020
Published: 06 March 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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