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Research Article

Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation

Wentao Song1, Yiming Wang1, Bing Wang2,3, Yingfang Yao1,2,3( ), Wenguang Wang2, Jinhui Wu2, Qing Shen4, Wenjun Luo1,2,3, Zhigang Zou1,2,3,5( )
Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Faculty of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan
Macau Institute of Systems Engineering, Macau University of Science and Technology, Macau 999078, China
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Abstract

Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired "stress-response" method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.

Keywords

CsPbBr3 nanocrystalsstress response encapsulationcancer diagnose

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Nano Research
Volume 13 Issue 3,
March 2020
Pages 795-801
DOI: 10.1007/s12274-020-2697-9
Cite this article:
Song W, Wang Y, Wang B, et al. Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation. Nano Research, 2020, 13(3): 795-801. https://doi.org/10.1007/s12274-020-2697-9
Topics:
BiocompatibilityBiomimetics Bromine compoundsDiagnosisFluorescenceMedical applicationsNanocrystalsPerovskiteProbesSilicaSilica nanoparticlesSiliconSiO2 nanoparticlesTumors

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Received: 28 October 2019
Revised: 01 February 2020
Accepted: 04 February 2020
Published: 16 March 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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