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Research Article

Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

Bo Yang1, Shan Zhou1, Jie Zeng1, Liping Zhang1, Runhao Zhang1, Kang Liang2, Lei Xie1, Bing Shao3, Shaoli Song4, Gang Huang5,6, Dongyuan Zhao1, Pu Chen7, Biao Kong1( )
Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai 200032, China
School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, NSW 2052, Australia
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China
Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
Institute of Clinical Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
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Abstract

Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.

Keywords

pH-responsivephotothermal therapymetal-polyphenol complexsynergistic therapy

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Nano Research
Volume 13 Issue 4,
April 2020
Pages 1013-1019
DOI: 10.1007/s12274-020-2736-6
Cite this article:
Yang B, Zhou S, Zeng J, et al. Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy. Nano Research, 2020, 13(4): 1013-1019. https://doi.org/10.1007/s12274-020-2736-6
Topics:
BiocompatibilityCardiovascular system Chemotherapy DiseasesInfrared devices Metal nanoparticlesSilicaSilica nanoparticlesTumors

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Received: 10 November 2019
Revised: 23 February 2020
Accepted: 25 February 2020
Published: 11 April 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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