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Research Article

Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer

Yanpeng Jia1,§, Yang Song3,§, Ying Qu1, Jinrong Peng1, Kun Shi1, Dan Du3, He Li2( ), Yuehe Lin3( ), Zhiyong Qian1( )
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu 610041, China
College of Optoelectronics Technology, Chengdu University of Information Technology, Chengdu 610225, China
School of Mechanical and Material Engineering, Washington State University, Pullman, WA 99163, USA

§ Yanpeng Jia and Yang Song contributed equally to this work.

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Abstract

The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’ targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.

Keywords

inorganic nanoparticlesphotoacoustic imagingporous structurephotothermal therapychemotherapy

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Nano Research
Volume 13 Issue 6,
June 2020
Pages 1739-1748
DOI: 10.1007/s12274-020-2800-2
Cite this article:
Jia Y, Song Y, Qu Y, et al. Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer. Nano Research, 2020, 13(6): 1739-1748. https://doi.org/10.1007/s12274-020-2800-2
Topics:
Binary alloysChemotherapy Medical imagingNanoparticlesOrganic acids Palladium alloysPlatinum alloysSynthesis (chemical)Tumors

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Received: 12 February 2020
Revised: 06 April 2020
Accepted: 11 April 2020
Published: 19 May 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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