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Research Article

Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy

Tongxu Gu1, Tong Chen1, Liang Cheng2, Xiang Li1( ), Gaorong Han1, Zhuang Liu2( )
State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China
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Abstract

Electrodynamic therapy (EDT) is a conceptually new cancer treatment approach recently proposed by our group. During EDT, the electro-driven catalytic reaction would occur on the surface of platinum nanoparticles (PtNPs) to produce reactive oxygen species (ROS) under the direct current (DC) or square-wave alternating current (AC) electric field. To further extend the potential of EDT, we hereby designed mesoporous silica-based nanocomposites decorated with PtNPs and loaded with anticancer drug doxorubicin (DOX) for synergistic electrodynamic-chemotherapy. Such silica-based nanocomposites could enable homogenous killing of large-sized tumors (over 500 mm3) and realize remarkable tumor destruction efficacy at a relatively low quantity of electricity. To our best knowledge, this is the first study to combine EDT and chemotherapy to develop a synergetic nanoplatform, openning a new dimension for the design of other EDT-based anticancer strategies.

Keywords

mesoporous silicaplatinum nanoparticleselectrodynamic therapychemotherapy

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Nano Research
Volume 13 Issue 8,
August 2020
Pages 2209-2215
DOI: 10.1007/s12274-020-2838-1
Cite this article:
Gu T, Chen T, Cheng L, et al. Mesoporous silica decorated with platinum nanoparticles for drug delivery and synergistic electrodynamic-chemotherapy. Nano Research, 2020, 13(8): 2209-2215. https://doi.org/10.1007/s12274-020-2838-1
Topics:
Catalysis Chemotherapy Electric fields NanocompositesNanoparticlesPlatinumSilicaTumors

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Received: 23 December 2019
Revised: 27 April 2020
Accepted: 29 April 2020
Published: 05 August 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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