A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Hongwei Lu; Yongjing Xu; Ruirui Qiao; Ziwei Lu; Pin Wang; Xindan Zhang; An Chen; Liming Zou; Zhongling Wang

doi:10.1007/s12274-020-2839-0

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Research Article

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

Hongwei Lu^{¹^,²}, Yongjing Xu^², Ruirui Qiao^³, Ziwei Lu^⁴, Pin Wang^⁵, Xindan Zhang^⁶, An Chen^¹, Liming Zou^²(

), Zhongling Wang^¹(

)

1Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China

2State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

3ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville VIC 3052, Australia

4Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

5Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210029, China

6Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China

Show Author Information

Graphical Abstract

Abstract

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we reported a novel super-paramagnetic iron oxide (SPIO) based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic purpose. This polyethylene glycol with four phenylboronic acid (PEG-B4)/CNTs@porphyrin (ph)/SPIO (BCPS) nanoplatform was simply prepared via integrated SPIO, ph, and a novel dendrimer with PEG liner and four PBA groups (PEG-B4) on the surface of carbon nanotubes (CNTs). Subsequently, a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO clustering. Moreover, the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer therapy. Furthermore, the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from PEG-B4. We showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor (1 mm) in the liver, but also effectively ablate tumors in a xenograft model, thereby achieving a complete cure rate of 100% at low laser dose. Our results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

Keywords

theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

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Nano Research

Volume 13 Issue 8,
August 2020

Pages 2216-2225

DOI: 10.1007/s12274-020-2839-0

Cite this article:

Lu H, Xu Y, Qiao R, et al. A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy. Nano Research, 2020, 13(8): 2216-2225. https://doi.org/10.1007/s12274-020-2839-0

Topics:

Carbon nanotubes Diseases Iron oxides Organic acids Theranostics Tumors

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Received: 02 February 2020

Revised: 27 April 2020

Accepted: 29 April 2020

Published: 05 August 2020