Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Shuo Du; Nuoya Zhou; Yujie Gao; Ge Xie; Hongyao Du; Hao Jiang; Lianbin Zhang; Juan Tao; Jintao Zhu

doi:10.1007/s12274-020-2891-9

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Research Article

Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing

Shuo Du^{¹^,^§}, Nuoya Zhou^{²^,^§}, Yujie Gao^¹, Ge Xie^¹, Hongyao Du^², Hao Jiang^¹, Lianbin Zhang^¹(

), Juan Tao^²(

), Jintao Zhu^¹(

)

1Key Lab of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

2Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

^§ Shuo Du and Nuoya Zhou contributed equally to this work.

Show Author Information

Graphical Abstract

Abstract

Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions. Electrical stimulation at the wound site is a compelling strategy for skin wound repair. However, there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue. Herein, we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator (HPSP) for promoting skin wound healing, which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride) nanofibers. The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion. We show that the HPSP not only promotes fibroblast proliferation and migration in vitro, but also effectively facilitates the collagen deposition, angiogenesis, and re-epithelialization in vivo with the increased expressions of crucial growth factors. The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3, greatly accelerating the healing process. This patch can serve as wearable and real-time electrical stimulation devices, potentially useful in clinical applications of skin wound healing.

Keywords

piezoelectric nanogenerator self-adhesive hydrogel hybrid patch electrical stimulation wound healing

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References

[1]

McLister,

; McHugh,

; Cundell,

; Davis,

New developments in smart bandage technologies for wound diagnostics. Adv. Mater. 2016, 28, 5732-5737.

Crossref Google Scholar

[2]

Gurtner,

G. C.

; Werner,

; Barrandon,

; Longaker,

M. T.

Wound repair and regeneration. Nature 2008, 453, 314-321.

Crossref Google Scholar

[3]

Martin,

Wound healing-aiming for perfect skin regeneration. Science 1997, 276, 75-81.

Crossref Google Scholar

[4]

Powers,

J. G.

; Higham,

; Broussard,

; Phillips,

T. J.

Wound healing and treating wounds: Chronic wound care and management. J. Am. Acad. Dermatol. 2016, 74, 607-625.

Crossref Google Scholar

[5]

Xi,

Y. W.

; Ge,

; Guo,

; Lei,

; Ma,

P. X.

Biomimetic elastomeric polypeptide-based nanofibrous matrix for overcoming multidrug-resistant bacteria and enhancing full-thickness wound healing/skin regeneration. ACS Nano 2018, 12, 10772-10784.

Crossref Google Scholar

[6]

Shi,

L. X.

; Liu,

; Wang,

W. S.

; Jiang,

; Wang,

S. T.

A self-pumping dressing for draining excessive biofluid around wounds. Adv. Mater. 2019, 31, 1804187.

Crossref Google Scholar

[7]

Augustine,

; Dan,

; Sosnik,

; Kalarikkal,

; Tran,

; Vincent,

; Thomas,

; Menu,

; Rouxel,

Electrospun poly(vinylidene fluoride-trifluoroethylene)/zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation. Nano Res. 2017, 10, 3358-3376.

Crossref Google Scholar

[8]

Liang,

Y. P.

; Zhao,

; Hu,

T. L.

; Chen,

B. J.

; Yin,

Z. H.

; Ma,

P. X.

; Guo,

B. L.

Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing. Small 2019, 15, 1900046.

Crossref Google Scholar

[9]

Qiu,

; Pu,

; Liu,

Z. W.

; Liu,

X. M.

; Dong,

; Liu,

C. Q.

; Ren,

J. S.

; Qu,

X. G.

Hydrogel-based artificial enzyme for combating bacteria and accelerating wound healing. Nano Res. 2020, 13, 496-502.

Crossref Google Scholar

[10]

Li,

W. P.

; Su,

C. H.

; Wang,

S. J.

; Tsai,

F. J.

; Chang,

C. T.

; Liao,

M. C.

; Yu,

C. C.

; Vi Tran,

T. T.

; Lee,

C. N.

; Chiu,

W. T.

et al. CO₂ delivery to accelerate incisional wound healing following single irradiation of near-infrared lamp on the coordinated colloids. ACS Nano 2017, 11, 5826-5835.

Crossref Google Scholar

[11]

Han,

; Ceilley,

Chronic wound healing: A review of current management and treatments. Adv. Ther. 2017, 34, 599-610.

Crossref Google Scholar

[12]

Bhang,

S. H.

; Jang,

W. S.

; Han,

; Yoon,

J. K.

; La,

W. G.

; Lee,

; Kim,

Y. S.

; Shin,

J. Y.

; Lee,

T. J.

; Baik,

H. K.

et al. Zinc oxide nanorod-based piezoelectric dermal patch for wound healing. Adv. Funct. Mater. 2017, 27, 1603497.

Crossref Google Scholar

[13]

Tian,

J. J.

; Shi,

; Liu,

; Ouyang,

; Yu,

; Zhao,

C. C.

; Zou,

; Jiang,

D. J.

; Zhang,

J. S.

; Li,

Self-powered implantable electrical stimulator for osteoblasts’ proliferation and differentiation. Nano Energy 2019, 59, 705-714.

Crossref Google Scholar

[14]

Wang,

A. C.

; Liu,

; Hu,

; Wang,

C. C.

; Zhang,

X. D.

; Shi,

B. J.

; Fan,

Y. B.

; Cui,

Y. G.

; Li,

; Ren,

K. L.

Piezoelectric nanofibrous scaffolds as in vivo energy harvesters for modifying fibroblast alignment and proliferation in wound healing. Nano Energy 2018, 43, 63-71.

Crossref Google Scholar

[15]

Zhao,

; Song,

; Pu,

; Wada,

; Reid,

; Tai,

G. P.

; Wang,

; Guo,

A. H.

; Walczysko,

; Gu,

et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN. Nature 2006, 442, 457-460.

Crossref Google Scholar

[16]

Huttenlocher,

; Horwitz,

A. R.

Wound healing with electric potential. N. Engl. J. Med. 2007, 356, 303-304.

Crossref Google Scholar

[17]

Zhao,

Electrical fields in wound healing—An overriding signal that directs cell migration. Semin. Cell Dev. Biol. 2009, 20, 674-682.

Crossref Google Scholar

[18]

Kloth,

L. C.

Electrical stimulation technologies for wound healing. Adv. Wound Care 2014, 3, 81-90.

Crossref Google Scholar

[19]

Long,

; Wei,

; Li,

; Yao,

; Yu,

; Ni,

D. L.

; Gibson,

A. L. F.

; Lan,

X. L.

; Jiang,

Y. D.

; Cai,

W. B.

et al. Effective wound healing enabled by discrete alternative electric fields from wearable nanogenerators. ACS Nano 2018, 12, 12533-12540.

Crossref Google Scholar

[20]

Kai,

; Yamauchi,

; Ogawa,

; Tsubota,

; Magome,

; Miyake,

; Yamasaki,

; Nishizawa,

Accelerated wound healing on skin by electrical stimulation with a bioelectric plaster. Adv. Healthc. Mater. 2017, 6, 1700465.

Crossref Google Scholar

[21]

Fan,

F. R.

; Tang,

; Wang,

Z. L.

Flexible nanogenerators for energy harvesting and self-powered electronics. Adv. Mater. 2016, 28, 4283-4305.

Crossref Google Scholar

[22]

Chang,

; Tran,

V. H.

; Wang,

J. B.

; Fuh,

Y. K.

; Lin,

L. W.

Direct-write piezoelectric polymeric nanogenerator with high energy conversion efficiency. Nano Lett. 2010, 10, 726-731.

Crossref Google Scholar

[23]

Li,

; Jie,

; Shao,

L. H.

; Guo,

Y. L.

; Cao,

; Wang,

Z. L.

All-in-one cellulose based hybrid tribo/piezoelectric nanogenerator. Nano Res. 2019, 12, 1831-1835.

Crossref Google Scholar

[24]

Parida,

; Bhavanasi,

; Kumar,

; Bendi,

; Lee,

P. S.

Self-powered pressure sensor for ultra-wide range pressure detection. Nano Res. 2017, 10, 3557-3570.

Crossref Google Scholar

[25]

Persano,

; Dagdeviren,

; Su,

Y. W.

; Zhang,

Y. H.

; Girardo,

; Pisignano,

; Huang,

Y. G.

; Rogers,

J. A.

High performance piezoelectric devices based on aligned arrays of nanofibers of poly(vinylidenefluoride-co-trifluoroethylene). Nat. Commun. 2013, 4, 1633.

Crossref Google Scholar

[26]

Yu,

Y. H.

; Sun,

H. Y.

; Orbay,

; Chen,

; England,

C. G.

; Cai,

W. B.

; Wang,

X. D.

Biocompatibility and in vivo operation of implantable mesoporous PVDF-based nanogenerators. Nano Energy 2016, 27, 275-281.

Crossref Google Scholar

[27]

Amjadi,

; Sheykhansari,

; Nelson,

B. J.

; Sitti,

Recent advances in wearable transdermal delivery systems. Adv. Mater. 2018, 30, 1704530.

Crossref Google Scholar

[28]

Lu,

N. S.

; Lu,

; Yang,

S. X.

; Rogers,

Highly sensitive skin-mountable strain gauges based entirely on elastomers. Adv. Funct. Mater. 2012, 22, 4044-4050.

Crossref Google Scholar

[29]

Griffin,

D. R.

; Weaver,

W. M.

; Scumpia,

P. O.

; Di Carlo,

; Segura,

Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks. Nat. Mater. 2015, 14, 737-744.

Crossref Google Scholar

[30]

Yu,

; Yuk,

; Parada,

G. A.

; Wu,

; Liu,

X. Y.

; Nabzdyk,

C. S.

; Youcef-Toumi,

; Zang,

J. F.

; Zhao,

X. H.

Multifunctional “hydrogel skins” on diverse polymers with arbitrary shapes. Adv. Mater. 2019, 31, 1807101.

Crossref Google Scholar

[31]

Han,

; Lu,

; Liu,

K. Z.

; Wang,

K. F.

; Fang,

L. M.

; Weng,

L. T.

; Zhang,

H. P.

; Tang,

Y. H.

; Ren,

F. Z.

; Zhao,

C. C.

et al. Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization. ACS Nano 2017, 11, 2561-2574.

Crossref Google Scholar

[32]

Liu,

Y. L.

; Ai,

K. L.

; Lu,

L. H.

Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 2014, 114, 5057-5115.

Crossref Google Scholar

[33]

Han,

; Yan,

L. W.

; Wang,

M. H.

; Wang,

K. F.

; Fang,

L. M.

; Zhou,

; Fang,

; Ren,

F. Z.

; Lu,

Transparent, adhesive, and conductive hydrogel for soft bioelectronics based on light-transmitting polydopamine-doped polypyrrole nanofibrils. Chem. Mater. 2018, 30, 5561-5572.

Crossref Google Scholar

[34]

Han,

; Yan,

L. W.

; Wang,

K. F.

; Fang,

L. M.

; Zhang,

H. P.

; Tang,

Y. H.

; Ding,

Y. H.

; Weng,

L. T.

; Xu,

J. L.

; Weng,

et al. Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality. NPG Asia Mater. 2017, 9, e372.

Crossref Google Scholar

[35]

Lee,

; Dellatore,

S. M.

; Miller,

W. M.

; Messersmith,

P. B.

Mussel-inspired surface chemistry for multifunctional coatings. Science 2007, 318, 426-430.

Crossref Google Scholar

[36]

Ghobril,

; Grinstaff,

M. W.

The chemistry and engineering of polymeric hydrogel adhesives for wound closure: A tutorial. Chem. Soc. Rev. 2015, 44, 1820-1835.

Crossref Google Scholar

[37]

Gao,

Y. J.

; Du,

H. Y.

; Xie,

Z. J.

; Li,

M. M.

; Zhu,

J. J.

; Xu,

J. W.

; Zhang,

L. B.

; Tao,

; Zhu,

J. T.

Self-adhesive photothermal hydrogel films for solar-light assisted wound healing. J. Mater. Chem. B 2019, 7, 3644-3651.

Crossref Google Scholar

[38]

Guo,

H. F.

; Li,

Z. S.

; Dong,

S. W.

; Chen,

W. J.

; Deng,

; Wang,

Y. F.

; Ying,

D. J.

Piezoelectric PU/PVDF electrospun scaffolds for wound healing applications. Colloids Surf. B 2012, 96, 29-36.

Crossref Google Scholar

[39]

Xiao,

J. S.

; Zhu,

Y. X.

; Huddleston,

; Li,

; Xiao,

B. X.

; Farha,

O. K.

; Ameer,

G. A.

Copper metal-organic framework nanoparticles stabilized with folic acid improve wound healing in diabetes. ACS Nano 2018, 12, 1023-1032.

Crossref Google Scholar

[40]

Wu,

; Huang,

W. M.

; Wu,

W. H.

; Xue,

; Xiang,

D. F.

; Li,

; Qin,

; Sun,

; Wang,

; Zhang,

W. B.

et al. Reversible hydrogels with tunable mechanical properties for optically controlling cell migration. Nano Res. 2018, 11, 5556-5565.

Crossref Google Scholar

[41]

Saito,

; Furukawa,

; Kurokawa,

; Kuwabara,

; Kuroda,

; Hu,

; Tanaka,

; Gong,

J. P.

; Kitamura,

; Yasuda,

Robust bonding and one-step facile synthesis of tough hydrogels with desirable shape by virtue of the double network structure. Polym. Chem. 2011, 2, 575-580.

Crossref Google Scholar

[42]

Li,

; Celiz,

A. D.

; Yang,

; Wamala,

; Whyte,

; Seo,

B. R.

; Vasilyev,

N. V.

; Vlassak,

J. J.

; Suo,

et al. Tough adhesives for diverse wet surfaces. Science 2017, 357, 378-381.

Crossref Google Scholar

[43]

Fang,

; Niu,

H. T.

; Wang,

H. X.

; Wang,

X. G.

; Lin,

Enhanced mechanical energy harvesting using needleless electrospun poly(vinylidene fluoride) nanofibre webs. Energy Environ. Sci. 2013, 6, 2196-2202.

Crossref Google Scholar

[44]

Tashiro,

; Kobayashi,

; Tadokoro,

Vibrational spectra and disorder-order transition of poly(vinylidene fluoride) form III. Macromolecules 1981, 14, 1757-1764.

Crossref Google Scholar

[45]

Fang,

; Wang,

X. G.

; Lin,

Electrical power generator from randomly oriented electrospun poly(vinylidene fluoride) nanofibre membranes. J. Mater. Chem. 2011, 21, 11088-11091.

Crossref Google Scholar

[46]

Wang,

X. X.

; Song,

W. Z.

; You,

M. H.

; Zhang,

; Yu,

; Fan,

Z. Y.

; Ramakrishna,

; Long,

Y. Z.

Bionic single-electrode electronic skin unit based on piezoelectric nanogenerator. ACS Nano 2018, 12, 8588-8596.

Crossref Google Scholar

[47]

Kang,

S. B.

; Won,

S. H.

; Im,

M. J.

; Kim,

C. U.

; Park,

W. I.

; Baik,

J. M.

; Choi,

K. J.

Enhanced piezoresponse of highly aligned electrospun poly(vinylidene fluoride) nanofibers. Nanotechnology 2017, 28, 395402.

Crossref Google Scholar

[48]

Ico,

; Showalter,

; Bosze,

; Gott,

S. C.

; Kim,

B. S.

; Rao,

M. P.

; Myung,

N. V.

; Nam,

Size-dependent piezoelectric and mechanical properties of electrospun P(VDF-TrFE) nanofibers for enhanced energy harvesting. J. Mater. Chem. A 2016, 4, 2293-2304.

Crossref Google Scholar

[49]

Persano,

; Dagdeviren,

; Maruccio,

; De Lorenzis,

; Pisignano,

Cooperativity in the enhanced piezoelectric response of polymer nanowires. Adv. Mater. 2014, 26, 7574-7580.

Crossref Google Scholar

[50]

Yan,

; Liu,

; Jeong,

Y. G.

; Kang,

W. M.

; Li,

; Zhao,

Y. X.

; Deng,

N. P.

; Cheng,

B. W.

; Yang,

Performance enhancements in poly(vinylidene fluoride)-based piezoelectric nanogenerators for efficient energy harvesting. Nano Energy 2019, 56, 662-692.

Crossref Google Scholar

[51]

Zhang,

L. L.

; Gui,

J. Z.

; Wu,

Z. Z.

; Li,

; Wang,

; Gong,

Z. Y.

; Zhao,

X. Z.

; Sun,

C. L.

; Guo,

S. S.

Enhanced performance of piezoelectric nanogenerator based on aligned nanofibers and three-dimensional interdigital electrodes. Nano Energy 2019, 65, 103924.

Crossref Google Scholar

[52]

Hofmann,

; Ritz,

; Verrier,

; Eglin,

; Alini,

; Fuchs,

; Kirkpatrick,

C. J.

; Rommens,

P. M.

The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds. Biomaterials 2008, 29, 4217-4226.

Crossref Google Scholar

Nano Research

Volume 13 Issue 9,
September 2020

Pages 2525-2533

DOI: 10.1007/s12274-020-2891-9

Cite this article:

Du S, Zhou N, Gao Y, et al. Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing. Nano Research, 2020, 13(9): 2525-2533. https://doi.org/10.1007/s12274-020-2891-9

Topics:

Cell culture Fluorine compounds Nanogenerators Plants (botany)Tissue regeneration Wearable technology

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Received: 01 March 2020

Revised: 19 May 2020

Accepted: 21 May 2020

Published: 25 June 2020