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Review Article

Advances of biological-camouflaged nanoparticles delivery system

Yanlin Chen, Kui Cheng( )
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
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Graphical Abstract

Abstract

Nanoparticles (NPs) which are innovation and research focus in drug delivery systems, still have some disadvantages limiting its application in clinical use, such as short circulation time, recognition and clearance by reticuloendothelial system (RES) and passive targeting in certain organs. However, the recent combination of natural components and nanotechnology has offered new solutions to address these problems. A novel biomimetic platform consisting of nanoparticle core and membrane shell, such as cell membrane, exosome or vesicle vastly improves properties of nanoparticles. These coated nanoparticles can replicate the unique functions of the membrane, such as prolonged blood circulation, active targeting capability and enhanced internalization. In this review, we focus on the newest development of biological-camouflaged nanoparticles and mainly introduce its application related to cancer therapy and toll-like receptor.

Keywords

biomimetic nanoparticlescell membranetumor therapytoll-like receptor (TLR)

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Nano Research
Volume 13 Issue 10,
October 2020
Pages 2617-2624
DOI: 10.1007/s12274-020-2931-5
Cite this article:
Chen Y, Cheng K. Advances of biological-camouflaged nanoparticles delivery system. Nano Research, 2020, 13(10): 2617-2624. https://doi.org/10.1007/s12274-020-2931-5
Topics:
Biomimetics Cardiovascular system Clinical researchControlled drug deliveryCytologyNanoparticles

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Received: 04 May 2020
Revised: 09 June 2020
Accepted: 12 June 2020
Published: 06 July 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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