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Research Article

iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy

Hai Huang1,§, Xiaorong Yang1,§, Huili Li1, Hansi Lu1, James Oswald2, Yongmei Liu1, Jun Zeng1, Chaohui Jin1, Xingchen Peng1, Jiyan Liu1, Xiangrong Song1( )
Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
School of Nanotechnology Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada

§ Hai Huang and Xiaorong Yang contributed equally to this work.

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Graphical Abstract

Abstract

Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation, resulting in low ocular bioavailability (< 5%). Worse still, the most convenient and safe route of ocular drug administration, topical administration results in a drug bioavailability of less than 1%. iRGD modified drug delivery strategies have been developed for cancer therapy, however active targeting iRGD platforms for ocular drug delivery have yet to be explored. Herein, an iRGD modified liposomes was developed for ocular drug delivery via topical administration. The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner. These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.

Keywords

ocular drug deliveryiRGD decorated liposomesactive corneal permeabilitytopical drops

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Nano Research
Volume 13 Issue 11,
November 2020
Pages 3105-3109
DOI: 10.1007/s12274-020-2980-9
Cite this article:
Huang H, Yang X, Li H, et al. iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy. Nano Research, 2020, 13(11): 3105-3109. https://doi.org/10.1007/s12274-020-2980-9
Topics:
Biochemistry Controlled drug deliveryDiseasesLiposomesTargeted drug delivery

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Received: 19 January 2020
Revised: 09 July 2020
Accepted: 10 July 2020
Published: 11 August 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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