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Research Article

Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies

Tao Chen, Lichao Su, Xiaoguang Ge, Wenmin Zhang, Qingqing Li, Xuan Zhang, Jiamin Ye, Lisen Lin, Jibin Song( ), Huanghao Yang( )
MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350116, China
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Abstract

Multimodal imaging in the second near-infrared window (NIR-II) guided cancer therapy is a highly precise and efficient cancer theranostic strategy. However, it is still a challenge to develop activated NIR-II optical imaging and therapy agents. In this study, we develop a pH-responsive hybrid plasmonic-fluorescent vesicle by self-assembly of amphiphilic plasmonic nanogapped gold nanorod (AuNNR) and fluorescent down-conversion nanoparticles (DCNP) (AuNNR-DCNP Ve), showing remarkable and activated NIR-II fluorescence (FL)/NIR-II photoacoustic (PA) imaging performances. The hybrid vesicle also exhibited superior loading capacity of doxorubicin as a superior drug carrier and efficient radiosensitizer for X-ray-induced radiotherapy. Interestingly, the accumulated hybrid AuNNR-DCNP Ve in the tumor resulted in a recovery of NIR-II FL imaging signal and a variation in NIR-II PA imaging signal. Dual activated NIR-II PA and FL imaging of the hybrid vesicle could trace drug release and precisely guided cancer radiotherapy to ultimately reduce the side effects to healthy tissue.

Keywords

radiotherapysecond near-infrared window (NIR-II)fluorescence imagingphotoacoustic imagingplasmonic gold nanovesicle

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Nano Research
Volume 13 Issue 12,
December 2020
Pages 3268-3277
DOI: 10.1007/s12274-020-3000-9
Cite this article:
Chen T, Su L, Ge X, et al. Dual activated NIR-II fluorescence and photoacoustic imaging-guided cancer chemo-radiotherapy using hybrid plasmonic-fluorescent assemblies. Nano Research, 2020, 13(12): 3268-3277. https://doi.org/10.1007/s12274-020-3000-9
Topics:
DiseasesDrug deliveryFluorescence imagingGold Nanorods Infrared devices NanorodsPlasmonic nanoparticles Plasmonics Self assemblyTheranostics

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Received: 21 June 2020
Revised: 19 July 2020
Accepted: 20 July 2020
Published: 14 August 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature
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