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Research Article

Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle

Fanchu Zeng1,2,§, Huan Qin1,2,§( ), Liming Liu1,2, Haocai Chang1,2, Qun Chen1,2, Linghua Wu1,2, Le Zhang1,2, Zhujun Wu1,2, Da Xing1,2( )
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China

§ Fanchu Zeng and Huan Qin contributed equally to this work.

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Graphical Abstract

Abstract

Effective therapeutic strategies to precisely eradicate primary tumors with minimal side effects on normal tissue, inhibit metastases, and prevent tumor relapses, are the ultimate goals in the battle against cancer. We report a novel therapeutic strategy that combines adjuvant black phosphorus nanoparticle-based photoacoustic (PA) therapy with checkpoint-blockade immunotherapy. With the mitochondria targeting nanoparticle, PA therapy can achieve localized mechanical damage of mitochondria via PA cavitation and thus achieve precise eradication of the primary tumor. More importantly, PA therapy can generate tumor-associated antigens via the presence of the R848-containing nanoparticles as an adjuvant to promote strong antitumor immune responses. When combined with the checkpoint-blockade using anti-cytotoxic T-lymphocyte antigen-4, the generated immunological responses will further promote the infiltrating CD8 and CD4 T-cells to increase the CD8/Foxp3 T-cell ratio to inhibit the growth of distant tumors beyond the direct impact range of the PA therapy. Furthermore, the number of memory T cells detected in the spleen is increased, and these cells inhibit tumor recurrence. This proposed strategy offers precise eradication of the primary tumor and can induce long-term tumor-specific immunity.

Keywords

photoacoustic therapymitochondrial targetingblack phosphorusimmunotherapycheckpoint blockade

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Nano Research
Volume 13 Issue 12,
December 2020
Pages 3403-3415
DOI: 10.1007/s12274-020-3028-x
Cite this article:
Zeng F, Qin H, Liu L, et al. Photoacoustic-immune therapy with a multi-purpose black phosphorus-based nanoparticle. Nano Research, 2020, 13(12): 3403-3415. https://doi.org/10.1007/s12274-020-3028-x
Topics:
Antigens CytologyNanoparticlesPhosphorusTumors

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Received: 23 June 2020
Revised: 28 July 2020
Accepted: 01 August 2020
Published: 29 August 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature
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