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Research Article

Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays

Jing Dai, Yuan Yao( )
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China
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Abstract

Matrix adaptation reconstructs the architecture of cell, and has important implication in proper biological functioning. However, how the network of cytoskeleton filament undergoes reconstruction, reordering, and surface adaptation, requires a systematic investigation. Here, we show that surface sensing and adaptation occur correspondingly with related reorganization of cytoskeleton filaments (actin, tubulin, and vimentin). The microstructure of filament network is built by adaptive change of chemical polymerization on cytoskeleton filaments. The transition of cellular morphology, from spheroidal architecture on nanoarray to extending structure with stress fibers on flat surface, involves spatial reorganization and polymerization modulation of filaments. The dimension of filaments (diameter, orientation, and density) are changed accordingly to spatiotemporal distribution of cytoskeleton network. In addition, our findings elucidate how cell can tune their architecture at nanoscale by matrix adaptation, and provide a novel information on interplay between cytoskeleton and pathophysiology.

Keywords

adaptationcytoskeletonpolymerizationreordering

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Nano Research
Volume 14 Issue 3,
March 2021
Pages 620-627
DOI: 10.1007/s12274-020-3076-2
Cite this article:
Dai J, Yao Y. Adaptive ordering and filament polymerization of cell cytoskeleton by tunable nanoarrays. Nano Research, 2021, 14(3): 620-627. https://doi.org/10.1007/s12274-020-3076-2
Topics:
MorphologyProteins

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Received: 10 June 2020
Revised: 28 July 2020
Accepted: 26 August 2020
Published: 01 March 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature
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