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Research Article

Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles

Xujiang Yu1,2,§,  Aodenggerile2,§, Zhao Jiang3, Jianliang Shen4,5, Zhiqiang Yan1( ), Wanwan Li3( ), Huibin Qiu2( )
Joint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China

§ Xujiang Yu and Aodenggerile contribute equally to this work.

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Abstract

Second near-infrared (NIR-II) fluorescence imaging is a recently emerged technique and is highly useful for accurate diagnosis of cancer. Although a diverse array of fluorescent nanomaterials have been developed to enable NIR-II fluorescence in various situations, they normally fail to unify the clinical techniques, such as computed tomography (CT) and magnetic resonance imaging (MRI). Therefore, exploiting multimodal agents to integrate the newly emerged NIR-II fluorescence and traditional clinical techniques would be of key significance. Here, we report a rational fabrication of neodymium (Nd)-doped gadolinium tungstate nanoparticles (NPs) that are subsequentially decorated with a hydrophilic layer and demonstrate that they can achieve the harmonious integration of NIR-II fluorescence imaging, CT, and MRI. The NIR-II fluorescence emission was activated by an incident light with discrete wavelength ranging from 250 to 810 nm. NIR-II fluorescence-CT-MRI associated trimodal imaging was subsequently demonstrated for breast cancer by an 808 nm laser, along with the estimation of NIR-II fluorescence imaging for cervical cancer. The integration of newly emerged and traditional clinical imaging techniques highlights the huge potential of rare-earth-doped NPs for multimodal imaging of different types of cancer.

Keywords

rare-earth-doped nanoparticles (NPs)second near-infrared fluorescencemultimodal imagingcancer

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Nano Research
Volume 14 Issue 7,
July 2021
Pages 2160-2170
DOI: 10.1007/s12274-020-3136-7
Cite this article:
Yu X, Aodenggerile, Jiang Z, et al. Integrating the second near-infrared fluorescence imaging with clinical techniques for multimodal cancer imaging by neodymium-doped gadolinium tungstate nanoparticles. Nano Research, 2021, 14(7): 2160-2170. https://doi.org/10.1007/s12274-020-3136-7
Topics:
DiseasesInfrared devices Magnetic resonance imagingMedical imagingNanoparticlesRare earthsTungsten compounds

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Received: 01 September 2020
Revised: 15 November 2020
Accepted: 24 November 2020
Published: 05 July 2021
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020
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