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Research Article

Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue

Yan Zhang1, Qiying Lv1, Kai Chi2, Qilin Li1, Huiling Fan1, Bo Cai1, Fei Xiao2( ), Shuai Wang2( ), Zheng Wang1( ), Lin Wang( )
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
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Graphical Abstract

Abstract

The development of hierarchical nanostructure is demonstrated as an effective strategy to improve catalytic activity and stability of electrocatalysts. Herein, a novel leaf-like hierarchically porous heterojunction flake arrays (FAs), integrated graphitic N-doped carbon (NC) with amorphous B,N-doped carbon (BNC), has been designed and grown on flexible carbon fiber (CF) using metal-organic framework (MOF) FAs and green ionic liquids as precursors. The hierarchical heterojunction structure possesses micro- and nano-scaled pores, large surface areas, and exposed high-density catalytic active sites, which enhances electronic conductivity and offers accessible transport channels for effectively decreasing mass transport resistance. The results of discrete Fourier transform (DFT) calculations and experiments also suggest that the catalytic activity has been promoted by the heterojunction structure through narrowing the banding gap. Consequently, the resultant nanohybrid microelectrode exhibits remarkable electrochemical sensing performance towards H2O2 with a low detection limit of 50 nM, and a high sensitivity of 213 μA·mM-1·cm-2, as well as good anti-interference capability. The practical application of nanohybrid fiber microelectrode has been explored by real-time monitoring H2O2 released from live colon cells and surgically-resected fresh colon cancer tissue, which can provide important information for the identification of different types of cells as well as distinguish cancer cells from normal ones. We believe this research will pave the way towards the development of advanced carbon nanomaterials for application in the fields of electrochemistry, biosensing, and cancer diagnosis.

Keywords

carbon heterojunction structurehierarchical flake arraysheteroatoms dopingelectrochemical sensorcancer biomarker detection

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Nano Research
Volume 14 Issue 5,
May 2021
Pages 1335-1343
DOI: 10.1007/s12274-020-3176-z
Cite this article:
Zhang Y, Lv Q, Chi K, et al. Hierarchical porous carbon heterojunction flake arrays derived from metal organic frameworks and ionic liquid for H2O2 electrochemical detection in cancer tissue. Nano Research, 2021, 14(5): 1335-1343. https://doi.org/10.1007/s12274-020-3176-z
Topics:
DiseasesDoping (additives)ElectrocatalystsHeterojunctionsMetalsNanostructured materialsOrganic frameworks Organic polymersOrganometallicsPorous materialsTissue

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Received: 01 July 2020
Revised: 03 October 2020
Accepted: 11 October 2020
Published: 17 November 2020
© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature
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