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Research Article

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhicheng Zhang1, Yawen Ding1, Jinbiao Li1, Li Wang1, Xiaoyan Xin2(), Jing Yan3(), Jinhui Wu1, Ahu Yuan1, Yiqiao Hu1()
State Key Laboratory of Pharmaceutical Biotechnology, Medical School /School of Life Sciences, Nanjing University, Nanjing 210093, China
Department of Radiology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Medical School/Clinical Cancer Institute, Nanjing University, Nanjing 210093, China
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Abstract

Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.

Keywords

ferroptosisvitamin K3 derivativenanoscale coordination polymerglutathione peroxidase attenuationiron pool increasehydrogen peroxide generation

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[1]
Dixon, S. J.; Lemberg, K. M.; Lamprecht, M. R.; Skouta, R.; Zaitsev, E. M.; Gleason, C. E.; Patel, D. N.; Bauer, A. J.; Cantley, A. M.; Yang, W. S. et al. Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell 2012, 149, 1060-1072.
Google Scholar
[2]
Stockwell, B. R.; Angeli, J. P. F.; Bayir, H.; Bush, A. I.; Conrad, M.; Dixon, S. J.; Fulda, S.; Gascón, S.; Hatzios, S. K.; Kagan, V. E. et al. Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell 2017, 171, 273-285.
Google Scholar
[3]
Xie, Y.; Hou, W.; Song, X.; Yu, Y.; Huang, J.; Sun, X.; Kang, R.; Tang, D. Ferroptosis: Process and function. Cell Death Differ. 2016, 23, 369-379.
Google Scholar
[4]
Yang, W. S.; Stockwell, B. R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 2016, 26, 165-176.
Google Scholar
[5]
Bayır, H.; Anthonymuthu, T. S.; Tyurina, Y. Y.; Patel, S. J.; Amoscato, A. A.; Lamade, A. M.; Yang, Q.; Vladimirov, G. K.; Philpott, C. C.; Kagan, V. E. Achieving life through death: Redox biology of lipid peroxidation in ferroptosis. Cell Chem. Biol. 2020, 27, 387-408.
Google Scholar
[6]
Zheng, D. W.; Lei, Q.; Zhu, J. Y.; Fan, J. X.; Li, C. X.; Li, C.; Xu, Z. S.; Cheng, S. X.; Zhang, X. Z. Switching apoptosis to ferroptosis: Metal-organic network for high-efficiency anticancer therapy. Nano Lett. 2017, 17, 284-291.
Google Scholar
[7]
Bolobajev, J.; Trapido, M.; Goi, A. Interaction of tannic acid with ferric iron to assist 2,4,6-trichlorophenol catalytic decomposition and reuse of ferric sludge as a source of iron catalyst in Fenton-based treatment. Appl. Catal. B: Environ. 2016, 187, 75-82.
Google Scholar
[8]
Yang, W. S.; SriRamaratnam, R.; Welsch, M. E.; Shimada, K.; Skouta, R.; Viswanathan, V. S.; Cheah, J. H.; Clemons, P. A.; Shamji, A. F.; Clish, C. B. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014, 156, 317-331.
Google Scholar
[9]
Zanganeh, S.; Hutter, G.; Spitler, R.; Lenkov, O.; Mahmoudi, M.; Shaw, A.; Pajarinen, J. S.; Nejadnik, H.; Goodman, S.; Moseley, M. et al. Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat. Nanotechnol. 2016, 11, 986-994.
Google Scholar
[10]
Zhang, C.; Bu, W. B.; Ni, D. L.; Zhang, S. J.; Li, Q.; Yao, Z. W.; Zhang, J. W.; Yao, H. L.; Wang, Z.; Shi, J. L. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction. Angew. Chem., Int. Ed. 2016, 55, 2101-2106.
Google Scholar
[11]
Jiang, L.; Kon, N.; Li, T. Y.; Wang, S. J.; Su, T.; Hibshoosh, H.; Baer, R.; Gu, W. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 2015, 520, 57-62.
Google Scholar
[12]
Reed, J. C.; Pellecchia, M. Ironing out cell death mechanisms. Cell 2012, 149, 963-965.
Google Scholar
[13]
Tetef, M.; Margolin, K.; Ahn, C.; Akman, S.; Chow, W.; Leong, L.; Morgan, R. J. Jr; Raschko, J.; Somlo, G.; Doroshow, J. H. Mitomycin C and menadione for the treatment of lung-cancer: A phase II trial. Invest. New Drugs 1995, 13, 157-162.
Google Scholar
[14]
Osada, S.; Tomita, H.; Tanaka, Y.; Tokuyama, Y.; Tanaka, H.; Sakashita, F.; Takahashi, T. The utility of vitamin K3 (menadione) against pancreatic cancer. Anticancer Res. 2008, 28, 45-50.
Google Scholar
[15]
Verrax, J.; Cadrobbi, J.; Marques, C.; Taper, H.; Habraken, Y.; Piette, J.; Calderon, P. B. Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non- apoptotic caspase-3 independent form of cell death. Apoptosis 2004, 9, 223-233.
Google Scholar
[16]
Suresh, S.; Raghu, D.; Karunagaran, D. Menadione (vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration. Asian Pac. J. Cancer Prev. 2013, 14, 5461-5465.
Google Scholar
[17]
Ngo, E. O.; Sun, T. P.; Chang, J. Y.; Wang, C. C.; Chi, K. H.; Cheng, A. L.; Nutter, L. M. Menadione-induced DNA damage in a human tumor cell line. Biochem. Pharmacol. 1991, 42, 1961-1968.
Google Scholar
[18]
Wellington, K. W. Understanding cancer and the anticancer activities of naphthoquinones - a review. RSC Adv. 2015, 5, 20309-20338.
Google Scholar
[19]
Pereyra, C. E.; Dantas, R. F.; Ferreira, S. B.; Gomes, L. P.; Silva, F. P. Jr. The diverse mechanisms and anticancer potential of naphthoquinones. Cancer Cell Int. 2019, 19, 207.
Google Scholar
[20]
Nematollahi, A.; Aminimoghadamfarouj, N.; Wiart, C. Reviews on 1,4-naphthoquinones from Diospyros L. J. Asian Nat. Prod. Res. 2012, 14, 80-88.
Google Scholar
[21]
Bauer, H.; Fritz-Wolf, K.; Winzer, A.; Kühner, S.; Little, S.; Yardley, V.; Vezin, H.; Palfey, B.; Schirmer, R. H.; Davioud-Charvet, E. A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'- naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme. J. Am. Chem. Soc. 2006, 128, 10784-10794.
Google Scholar
[22]
Davioud-Charvet, E.; Delarue, S.; Biot, C.; Schwobel, B.; Boehme, C. C.; Müssigbrodt, A.; Maes, L.; Sergheraert, C.; Grellier, P.; Schirmer, R. H. et al. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. J. Med. Chem. 2001, 44, 4268-4276.
Google Scholar
[23]
Biot, C.; Bauer, H.; Schirmer, R. H.; Davioud-Charvet, E. 5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials. J. Med. Chem. 2004, 47, 5972-5983.
Google Scholar
[24]
Zhang, J. M.; Li, X. M.; Han, X.; Liu, R. J.; Fang, J. G. Targeting the thioredoxin system for cancer therapy. Trends Pharmacol. Sci. 2017, 38, 794-808.
Google Scholar
[25]
Liu, T.; Liu, W. L.; Zhang, M. K.; Yu, W. Y.; Gao, F.; Li, C. X.; Wang, S. B.; Feng, J.; Zhang, X. Z. Ferrous-supply-regeneration nanoengineering for cancer-cell-specific ferroptosis in combination with imaging-guided photodynamic therapy. ACS Nano 2018, 12, 12181-12192.
Google Scholar
[26]
Li, Y. Q.; Wang, X. Y.; Yan, J. J.; Liu, Y.; Yang, R. L.; Pan, D. H.; Wang, L. Z.; Xu, Y. P.; Li, X. T.; Yang, M. Nanoparticle ferritin-bound erastin and rapamycin: A nanodrug combining autophagy and ferroptosis for anticancer therapy. Biomater. Sci. 2019, 7, 3779-3787.
Google Scholar
[27]
Haas, K. L.; Franz, K. J. Application of metal coordination chemistry to explore and manipulate cell biology. Chem. Rev. 2009, 109, 4921-4960.
Google Scholar
[28]
Carrano, C. J.; Drechsel, H.; Kaiser, D.; Jung, G.; Matzanke, B.; Winkelmann, G.; Rochel, N.; Albrecht-Gary, A. M. Coordination chemistry of the carboxylate type siderophore rhizoferrin: The iron(III) complex and its metal analogs. Inorg. Chem. 1996, 35, 6429-6436.
Google Scholar
[29]
Holt, P. D.; Reid, R. R.; Lewis, B. L.; Luther, G. W.; Butler, A. Iron(III) coordination chemistry of alterobactin A: A siderophore from the marine bacterium Alteromonas luteoviolacea. Inorg. Chem. 2005, 44, 7671-7677.
Google Scholar
[30]
Butler, A.; Theisen, R. M. Iron(III)-siderophore coordination chemistry: Reactivity of marine siderophores. Coord. Chem. Rev. 2010, 254, 288-296.
Google Scholar
[31]
Goldstein, S.; Meyerstein, D.; Czapski, G. The Fenton reagents. Free Radical Biol. Med. 1993, 15, 435-445.
Google Scholar
[32]
Puzyn, T.; Rasulev, B.; Gajewicz, A.; Hu, X. K.; Dasari, T. P.; Michalkova, A.; Hwang, H. M.; Toropov, A.; Leszczynska, D.; Leszczynski, J. Using Nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles. Nat. Nanotechnol. 2011, 6, 175-178.
Google Scholar
[33]
Brillas, E.; Sirés, I.; Oturan, M. A. Electro-Fenton process and related electrochemical technologies based on Fenton's reaction chemistry. Chem. Rev. 2009, 109, 6570-6631.
Google Scholar
[34]
Voinov, M. A.; Pagan, J. O. S.; Morrison, E.; Smirnova, T. I.; Smirnov, A. I. Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity. J. Am. Chem. Soc. 2011, 133, 35-41.
Google Scholar
[35]
Fitzsimmons, S. A.; Workman, P.; Grever, M.; Paull, K.; Camalier, R.; Lewis, A. D. Reductase enzyme expression across the national cancer institute tumor cell line panel: Correlation with sensitivity to mitomycin C and EO9. J. Natl. Cancer Inst. 1996, 88, 259-269.
Google Scholar
[36]
Hayes, J. D.; Dinkova-Kostova, A. T.; Tew, K. D. Oxidative stress in cancer. Cancer Cell 2020, 38, 167-197.
Google Scholar
[37]
Perillo, B.; Di Donato, M.; Pezone, A.; Di Zazzo, E.; Giovannelli, P.; Galasso, G.; Castoria, G.; Migliaccio, A. ROS in cancer therapy: The bright side of the moon. Exp. Mol. Med. 2020, 52, 192-203.
Google Scholar
[38]
Trachootham, D.; Alexandre, J.; Huang, P. Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat. Rev. Drug Discov. 2009, 8, 579-591.
Google Scholar
[39]
Harris, I. S.; Treloar, A. E.; Inoue, S.; Sasaki, M.; Gorrini, C.; Lee, K. C.; Yung, K. Y.; Brenner, D.; Knobbe-Thomsen, C. B.; Cox, M. A. et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 2015, 27, 211-222.
Google Scholar
[40]
Holmgren, A.; Lu, J. Thioredoxin and thioredoxin reductase: Current research with special reference to human disease. Biochem. Biophys. Res. Commun. 2010, 396, 120-124.
Google Scholar
[41]
Liu, Q. Q.; Du, K. K.; Liu, M.; Lv, R. M.; Sun, B. W.; Cao, D. W.; He, N. Y.; Wang, Z. F. Sulfosalicylic acid/Fe3+ based nanoscale coordination polymers for effective cancer therapy by the Fenton reaction: An inspiration for understanding the role of aspirin in the prevention of cancer. Biomater. Sci. 2019, 7, 5482-5491.
Google Scholar
[42]
Piskounova, E.; Agathocleous, M.; Murphy, M. M.; Hu, Z. P.; Huddlestun, S. E.; Zhao, Z. Y.; Leitch, A. M.; Johnson, T. M.; DeBerardinis, R. J.; Morrison, S. J. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature 2015, 527, 186-191.
Google Scholar
[43]
Zhang, P. H.; An, K. L.; Duan, X. M.; Xu, H.; Li, F.; Xu, F. Recent advances in siRNA delivery for cancer therapy using smart nanocarriers. Drug Discov. Today 2018, 23, 900-911.
Google Scholar
[44]
Singh, A.; Bodas, M.; Wakabayashi, N.; Bunz, F.; Biswal, S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid. Redox Signal. 2010, 13, 1627-1637.
Google Scholar
[45]
Zhou, S. N.; Ye, W. G.; Shao, Q. J.; Zhang, M. X.; Liang, J. Nrf2 is a potential therapeutic target in radioresistance in human cancer. Crit. Rev. Oncol. Hematol. 2013, 88, 706-715.
Google Scholar
[46]
Wang, H.; Jiang, H.; Corbet, C.; De Mey, S.; Law, K.; Gevaert, T.; Feron, O.; De Ridder, M. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: Involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. Cancer Lett. 2019, 450, 42-52.
Google Scholar
[47]
Schaue, D.; McBride, W. H. Opportunities and challenges of radiotherapy for treating cancer. Nat. Rev. Clin. Oncol. 2015, 12, 527-540.
Google Scholar
[48]
Fruehauf, J. P.; Meyskens, F. L. Jr. Reactive oxygen species: A breath of life or death? Clin. Cancer Res. 2007, 13, 789-794.
Google Scholar
[49]
Schumacker, P. T. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell 2006, 10, 175-176.
Google Scholar
[50]
Trachootham, D.; Lu, W. Q.; Ogasawara, M. A.; Nilsa, R. D. V.; Huang, P. Redox regulation of cell survival. Antioxid. Redox Signal. 2008, 10, 1343-1374.
Google Scholar
[51]
Jorgenson, T. C.; Zhong, W. X.; Oberley, T. D. Redox imbalance and biochemical changes in cancer. Cancer Res. 2013, 73, 6118-6123.
Google Scholar
[52]
Huo, M. F.; Wang, L. Y.; Wang, Y. W.; Chen, Y.; Shi, J. L. Nanocatalytic tumor therapy by single-atom catalysts. ACS Nano 2019, 13, 2643-2653.
Google Scholar
[53]
Zhang, D.; Zhao, Y. X.; Gao, Y. J.; Gao, F. P.; Fan, Y. S.; Li, X. J.; Duan, Z. Y.; Wang, H. Anti-bacterial and in vivo tumor treatment by reactive oxygen species generated by magnetic nanoparticles. J. Mater. Chem. B 2013, 1, 5100-5107.
Google Scholar
[54]
Dickinson, B. C.; Chang, C. J. Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat. Chem. Biol. 2011, 7, 504-511.
Google Scholar
[55]
Wang, S.; Wang, Z. T.; Yu, G. C.; Zhou, Z. J.; Jacobson, O.; Liu, Y. J.; Ma, Y.; Zhang, F. W.; Chen, Z. Y.; Chen, X. Y. Tumor-specific drug release and reactive oxygen species generation for cancer chemo/chemodynamic combination therapy. Adv. Sci. 2019, 6, 1801986.
Google Scholar
[56]
Huang, G.; Chen, H. B.; Dong, Y.; Luo, X. Q.; Yu, H. J.; Moore, Z.; Bey, E. A.; Boothman, D. A.; Gao, J. M. Superparamagnetic iron oxide nanoparticles: Amplifying ROS stress to improve anticancer drug efficacy. Theranostics 2013, 3, 116-126.
Google Scholar
[57]
Shen, Z. Y.; Song, J. B.; Yung, B. C.; Zhou, Z. J.; Wu, A. G.; Chen, X. Y. Emerging strategies of cancer therapy based on ferroptosis. Adv. Mater. 2018, 30, 1704007.
Google Scholar
[58]
Wang, S. F.; Li, F. Y.; Qiao, R. R.; Hu, X.; Liao, H. R.; Chen, L. M.; Wu, J. H.; Wu, H. B.; Zhao, M.; Liu, J. N. et al. Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics. ACS Nano 2018, 12, 12380-12392.
Google Scholar
[59]
Zou, Y. L.; Palte, M. J.; Deik, A. A.; Li, H. X.; Eaton, J. K.; Wang, W. Y.; Tseng, Y. Y.; Deasy, R.; Kost-Alimova, M.; Dančík, V. et al. A GPX4- dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat. Commun. 2019, 10, 1617.
Google Scholar
[60]
Oh, M.; Mirkin, C. A. Chemically tailorable colloidal particles from infinite coordination polymers. Nature 2005, 438, 651-654.
Google Scholar
[61]
Novio, F.; Simmchen, J.; Vázquez-Mera, N.; Amorín-Ferré, L.; Ruiz-Molina, D. Coordination polymer nanoparticles in medicine. Coord. Chem. Rev. 2013, 257, 2839-2847.
Google Scholar
[62]
Masoomi, M. Y.; Morsali, A. Applications of metal-organic coordination polymers as precursors for preparation of nano-materials. Coord. Chem. Rev. 2012, 256, 2921-2943.
Google Scholar
[63]
Bagherzadeh, M.; Ashouri, F.; Hashemi, L.; Morsali, A. Supported Pd nanoparticles on Mn-based metal-organic coordination polymer: Efficient and recyclable heterogeneous catalyst for mizoroki-heck cross coupling reaction of terminal alkenes. Inorg. Chem. Commun. 2014, 44, 10-14.
Google Scholar
[64]
Mohammadikish, M.; Yarahmadi, S.; Molla, F. A new water-insoluble coordination polymer as efficient dye adsorbent and olefin epoxidation catalyst. J. Environ. Manag. 2020, 254, 109784.
Google Scholar
[65]
Nishiyabu, R.; Hashimoto, N.; Cho, T.; Watanabe, K.; Yasunaga, T.; Endo, A.; Kaneko, K.; Niidome, T.; Murata, M.; Adachi, C. et al. Nanoparticles of adaptive supramolecular networks self-assembled from nucleotides and lanthanide ions. J. Am. Chem. Soc. 2009, 131, 2151-2158.
Google Scholar
[66]
Taylor, K. M. L.; Rieter, W. J.; Lin, W. B. Manganese-based nanoscale metal-organic frameworks for magnetic resonance imaging. J. Am. Chem. Soc. 2008, 130, 14358-14359.
Google Scholar
[67]
Taylor-Pashow, K. M. L.; Della Rocca, J.; Xie, Z. G.; Tran, S.; Lin, W. B. Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery. J. Am. Chem. Soc. 2009, 131, 14261-14263.
Google Scholar
[68]
Novio, F.; Lorenzo, J.; Nador, F.; Wnuk, K.; Ruiz-Molina, D. Carboxyl group (-CO2H) functionalized coordination polymer nanoparticles as efficient platforms for drug delivery. Chem.-Eur. J. 2014, 20, 15443-15450.
Google Scholar
[69]
Huxford, R. C.; deKrafft, K. E.; Boyle, W. S.; Liu, D. M.; Lin, W. B. Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells. Chem. Sci. 2012, 3, 198-204.
Google Scholar
[70]
Ma, B. J.; Wang, S.; Liu, F.; Zhang, S.; Duan, J. Z.; Li, Z.; Kong, Y.; Sang, Y. H.; Liu, H.; Bu, W. B. et al. Self-assembled copper-amino acid nanoparticles for in situ glutathione "AND" H2O2 sequentially triggered chemodynamic therapy. J. Am. Chem. Soc. 2019, 141, 849-857.
Google Scholar
[71]
Pearson, R. G. Hard and soft acids and bases. J. Am. Chem. Soc. 1963, 85, 3533-3539.
Google Scholar
[72]
Pelicano, H.; Carney, D.; Huang, P. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updates 2004, 7, 97-110.
Google Scholar
[73]
Cairns, R. A.; Harris, I. S.; Mak, T. W. Regulation of cancer cell metabolism. Nat. Rev. Cancer 2011, 11, 85-95.
Google Scholar
[74]
Prasad, S.; Gupta, S. C.; Tyagi, A. K. Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Lett. 2017, 387, 95-105.
Google Scholar
[75]
D’Autréaux, B.; Toledano, M. B. ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis. Nat. Rev. Mol. Cell Biol. 2007, 8, 813-824.
Google Scholar
[76]
Ray, P. D.; Huang, B. W.; Tsuji, Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell. Signal. 2012, 24, 981-990.
Google Scholar
[77]
Meister, A. Selective modification of glutathione metabolism. Science 1983, 220, 472-477.
Google Scholar
[78]
Bailey, H. H.; Ripple, G.; Tutsch, K. D.; Arzoomanian, R. Z.; Alberti, D.; Feierabend, C.; Mahvi, D.; Schink, J.; Pomplun, M.; Mulcahy, R. T. et al. Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. J. Natl. Cancer Inst. 1997, 89, 1789-1796.
Google Scholar
[79]
Qu, Y.; Wang, J. H.; Ray, P. S.; Guo, H.; Huang, J. A.; Shin-Sim, M.; Bukoye, B. A.; Liu, B. Y.; Lee, A. V.; Lin, X. et al. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. J. Clin. Invest. 2011, 121, 212-225.
Google Scholar
[80]
Bhatia, M.; McGrath, K. L.; Di Trapani, G.; Charoentong, P.; Shah, F.; King, M. M.; Clarke, F. M.; Tonissen, K. F. The thioredoxin system in breast cancer cell invasion and migration. Redox Biol. 2016, 8, 68-78.
Google Scholar
[81]
Kobayashi, K.; Usami, N.; Porcel, E.; Lacombe, S.; Le Sech, C. Enhancement of radiation effect by heavy elements. Mutat. Res. Rev. Mutat. Res. 2010, 704, 123-131.
Google Scholar
[82]
De La Vega, M. R.; Chapman, E.; Zhang, D. D. NRF2 and the hallmarks of cancer. Cancer Cell 2018, 34, 21-43.
Google Scholar
[83]
Salmon-Chemin, L.; Buisine, E.; Yardley, V.; Kohler, S.; Debreu, M. A.; Landry, V.; Sergheraert, C.; Croft, S. L.; Krauth-Siegel, R. L.; Davioud- Charvet, E. 2-and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity. J. Med. Chem. 2001, 44, 548-565.
Google Scholar
[84]
Saywell, L. G.; Cunningham, B. B. Determination of iron: Colorimetric o-phenanthroline method. Ind. Eng. Chem. Anal. Ed. 1937, 9, 67-69.
Google Scholar
[85]
Drummen, G. P. C.; Van Liebergen, L. C. M.; Den Kamp, J. A. F. O.; Post, J. A. C11-BODIPY581/591, an oxidation-sensitive fluorescent lipid peroxidation probe: (Micro) spectroscopic characterization and validation of methodology. Free Radic. Biol. Med. 2002, 33, 473-490.
Google Scholar
Nano Research
Volume 14 Issue 7,
July 2021
Pages 2398-2409
DOI: 10.1007/s12274-020-3241-7
Cite this article:
Zhang Z, Ding Y, Li J, et al. Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy. Nano Research, 2021, 14(7): 2398-2409. https://doi.org/10.1007/s12274-020-3241-7
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